Details for: MBD5
Gene ID: 55777
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: MBD5
Ensembl ID: ENSG00000204406
Description: methyl-CpG binding domain protein 5
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 65.81rCSI 78.62%PRS 68.8
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CSI 64.98rCSI 80.84%PRS 66.62
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CSI 60.79rCSI 78.36%PRS 69.89
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CSI 50.85rCSI 81.78%PRS 70.06
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CSI 48.41rCSI 81.26%PRS 68.65
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CSI 44.96rCSI 79.41%PRS 68.21
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CSI 44.22rCSI 91.76%PRS 82.16
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CSI 43.94rCSI 63.06%PRS 75.59
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CSI 43.43rCSI 78.91%PRS 76.99
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CSI 42.98rCSI 69.17%PRS 75.94
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CSI 41.68rCSI 78.06%PRS 74.54
-
CSI 37.78rCSI 83.14%PRS 67.15
-
CSI 37.4rCSI 48.02%PRS 75.65
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CSI 36.44rCSI 31.26%PRS 89.76
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CSI 35.66rCSI 77.36%PRS 72.93
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CSI 34.4rCSI 32.51%PRS 83.1
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CSI 34.03rCSI 58.87%PRS 77.5
-
CSI 33.07rCSI 46.88%PRS 82.13
-
CSI 32.68rCSI 53.52%PRS 75.66
-
CSI 32.57rCSI 79.16%PRS 66.52
-
CSI 32.11rCSI 76.79%PRS 72.56
-
CSI 31.96rCSI 85.11%PRS 72.3
-
CSI 31.02rCSI 68.53%PRS 72.02
-
CSI 30.88rCSI 78.33%PRS 76.65
-
CSI 29.77rCSI 24.06%PRS 91.7
-
CSI 29.57rCSI 66.29%PRS 69.59
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CSI 29.52rCSI 73.06%PRS 85.3
-
CSI 29.45rCSI 66.83%PRS 84.39
-
CSI 29.17rCSI 51.14%PRS 79.61
-
CSI 27.68rCSI 40.69%PRS 78.4
-
CSI 27.65rCSI 58.92%PRS 60.73
-
CSI 26.75rCSI 36.6%PRS 76.38
-
CSI 26.74rCSI 15.79%PRS 96.51
-
CSI 26.13rCSI 19.59%PRS 96.3
-
CSI 25.69rCSI 18.04%PRS 94.59
-
CSI 25.57rCSI 79.96%PRS 72.35
-
CSI 25.32rCSI 58.45%PRS 73.91
-
CSI 25.08rCSI 19.82%PRS 75.47
-
CSI 24.93rCSI 18.65%PRS 94.56
-
CSI 24.63rCSI 60.16%PRS 77.58
-
CSI 24.43rCSI 63.65%PRS 79.02
-
CSI 24.06rCSI 16.72%PRS 94.22
-
CSI 23.95rCSI 74.84%PRS 70.19
-
CSI 23.81rCSI 30.56%PRS 81.22
-
CSI 23.39rCSI 35.29%PRS 89.73
-
CSI 23.17rCSI 20.29%PRS 90.55
-
CSI 22.72rCSI 74.67%PRS 71.39
-
CSI 22.63rCSI 35.99%PRS 78.72
-
CSI 22.49rCSI 60.11%PRS 77.76
-
CSI 22.12rCSI 19.23%PRS 92.47
-
CSI 21.55rCSI 43.74%PRS 65.08
-
CSI 21.35rCSI 76.83%PRS 66.64
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CSI 21.14rCSI 61.28%PRS 75.11
-
CSI 20.5rCSI 38.7%PRS 91.33
-
CSI 20.45rCSI 21.04%PRS 93.25
-
CSI 20.4rCSI 69.11%PRS 80.4
-
CSI 20.32rCSI 76.81%PRS 69.04
-
CSI 19.92rCSI 68.23%PRS 71.21
-
CSI 19.88rCSI 22.96%PRS 77.36
-
CSI 19.05rCSI 13.68%PRS 94.97
-
CSI 18.7rCSI 48.74%PRS 86.04
-
CSI 18.66rCSI 44.85%PRS 86.82
-
CSI 18.11rCSI 13.96%PRS 88.19
-
CSI 17.98rCSI 46.72%PRS 84.54
-
CSI 17.72rCSI 35.59%PRS 76.68
-
CSI 17.64rCSI 28.14%PRS 76.76
-
CSI 17.42rCSI 35.79%PRS 72.21
-
CSI 17.37rCSI 16.05%PRS 95.68
-
CSI 17.14rCSI 23.82%PRS 83.24
-
CSI 17.08rCSI 64.45%PRS 68.36
-
CSI 16.65rCSI 73.18%PRS 79.55
-
CSI 16.59rCSI 42.64%PRS 81.14
-
CSI 16.4rCSI 22.71%PRS 81.32
-
CSI 16.33rCSI 76.8%PRS 75.62
-
CSI 15.99rCSI 28.18%PRS 80.43
-
CSI 15.61rCSI 16.28%PRS 84.19
-
CSI 15.31rCSI 20.93%PRS 88.81
-
CSI 15.08rCSI 34.49%PRS 85.93
-
CSI 15rCSI 27.49%PRS 87.46
-
CSI 14.92rCSI 48.02%PRS 81.55
-
CSI 14.84rCSI 78.01%PRS 75.32
-
CSI 14.69rCSI 26.39%PRS 78.98
-
CSI 14.48rCSI 11.99%PRS 87.03
-
CSI 14.37rCSI 31.63%PRS 87.92
-
CSI 14.04rCSI 38.69%PRS 80.81
-
CSI 13.8rCSI 70.67%PRS 87.17
-
CSI 13.25rCSI 78.03%PRS 69.16
-
CSI 13.13rCSI 53.5%PRS 76.92
-
CSI 12.92rCSI 13.16%PRS 92.27
-
CSI 12.79rCSI 75.5%PRS 76.14
-
CSI 12.51rCSI 70%PRS 84.44
-
CSI 12.51rCSI 66.46%PRS 75.48
-
CSI 12.49rCSI 9.39%PRS 89.66
-
CSI 12.46rCSI 62.72%PRS 81.46
-
CSI 12.36rCSI 22.12%PRS 84.15
-
CSI 12.26rCSI 14.36%PRS 95.12
-
CSI 12.21rCSI 14.58%PRS 95.9
-
CSI 12.11rCSI 35.77%PRS 76.25
-
CSI 12.09rCSI 82.29%PRS 76.92
-
CSI 11.94rCSI 30.87%PRS 81.05
-
CSI 0.5rCSI 2.6%PRS 90.8%
-
CSI 0.9rCSI 3.7%PRS 88.1%
-
CSI 1.0rCSI 5.7%PRS 86.5%
-
CSI 1.0rCSI 5.8%PRS 88.7%
-
CSI 1.2rCSI 4.2%PRS 97.4%
-
CSI 1.2rCSI 5.2%PRS 90.7%
-
CSI 1.2rCSI 3.3%PRS 89.8%
-
CSI 1.2rCSI 3.2%PRS 93.6%
-
CSI 1.5rCSI 7.5%PRS 94.2%
-
CSI 1.5rCSI 11.6%PRS 85.6%
-
CSI 1.7rCSI 1.5%PRS 75.0%
-
CSI 1.7rCSI 7.5%PRS 73.5%
-
CSI 1.7rCSI 9.1%PRS 88.6%
-
CSI 1.8rCSI 6.8%PRS 96.0%
-
CSI 1.9rCSI 10.4%PRS 91.6%
-
CSI 1.9rCSI 3.0%PRS 91.5%
-
CSI 1.9rCSI 4.4%PRS 89.0%
-
CSI 2.1rCSI 5.4%PRS 89.6%
-
CSI 2.1rCSI 2.8%PRS 89.5%
-
CSI 2.2rCSI 20.4%PRS 84.1%
-
CSI 2.4rCSI 15.1%PRS 79.8%
-
CSI 2.4rCSI 6.6%PRS 80.1%
-
CSI 2.4rCSI 5.0%PRS 80.8%
-
CSI 2.4rCSI 3.5%PRS 94.9%
-
CSI 2.5rCSI 3.4%PRS 95.8%
-
CSI 2.5rCSI 7.3%PRS 93.0%
-
CSI 2.5rCSI 12.4%PRS 90.7%
-
CSI 2.5rCSI 3.6%PRS 82.6%
-
CSI 2.6rCSI 3.3%PRS 87.5%
-
CSI 2.6rCSI 19.3%PRS 92.0%
-
CSI 2.6rCSI 3.3%PRS 83.2%
-
CSI 2.7rCSI 3.2%PRS 92.0%
-
CSI 2.7rCSI 12.6%PRS 93.5%
-
CSI 2.7rCSI 15.2%PRS 86.5%
-
CSI 2.7rCSI 17.5%PRS 90.8%
-
CSI 2.7rCSI 28.8%PRS 81.1%
-
CSI 2.8rCSI 5.3%PRS 87.6%
-
CSI 2.8rCSI 6.6%PRS 87.3%
-
CSI 2.8rCSI 4.4%PRS 86.0%
-
CSI 2.9rCSI 7.9%PRS 88.4%
-
CSI 3.0rCSI 4.6%PRS 83.7%
-
CSI 3.1rCSI 2.1%PRS 95.1%
-
CSI 3.1rCSI 5.7%PRS 92.3%
-
CSI 3.2rCSI 76.3%PRS 67.0%
-
CSI 3.2rCSI 76.5%PRS 66.6%
-
CSI 3.2rCSI 4.1%PRS 89.3%
-
CSI 3.3rCSI 4.0%PRS 83.2%
-
CSI 3.3rCSI 2.7%PRS 87.0%
-
CSI 3.3rCSI 7.3%PRS 88.9%
-
CSI 3.4rCSI 5.0%PRS 84.5%
-
CSI 3.4rCSI 3.9%PRS 78.2%
-
CSI 3.5rCSI 9.9%PRS 89.0%
-
CSI 3.8rCSI 8.3%PRS 90.3%
-
CSI 3.8rCSI 76.4%PRS 76.0%
-
CSI 3.8rCSI 8.6%PRS 78.3%
-
CSI 3.8rCSI 3.3%PRS 88.1%
-
CSI 3.8rCSI 17.0%PRS 92.1%
-
CSI 3.8rCSI 3.7%PRS 79.6%
-
CSI 3.8rCSI 78.0%PRS 75.1%
-
CSI 3.9rCSI 3.5%PRS 83.5%
-
CSI 4.0rCSI 62.9%PRS 85.9%
-
CSI 4.1rCSI 3.2%PRS 88.8%
-
CSI 4.1rCSI 36.2%PRS 72.6%
-
CSI 4.1rCSI 9.8%PRS 87.9%
-
CSI 4.2rCSI 36.1%PRS 79.2%
-
CSI 4.2rCSI 43.6%PRS 78.7%
-
CSI 4.2rCSI 13.1%PRS 88.0%
-
CSI 4.3rCSI 3.3%PRS 88.1%
-
CSI 4.3rCSI 25.0%PRS 81.4%
-
CSI 4.4rCSI 3.5%PRS 96.9%
-
CSI 4.4rCSI 9.8%PRS 93.9%
-
CSI 4.4rCSI 11.3%PRS 96.2%
-
CSI 4.4rCSI 4.3%PRS 87.0%
-
CSI 4.4rCSI 12.8%PRS 84.0%
-
CSI 4.5rCSI 6.9%PRS 91.8%
-
CSI 4.7rCSI 5.0%PRS 86.8%
-
CSI 4.8rCSI 10.8%PRS 90.9%
-
CSI 4.9rCSI 7.2%PRS 87.7%
-
CSI 4.9rCSI 30.5%PRS 77.5%
-
CSI 4.9rCSI 30.9%PRS 64.1%
-
CSI 5.0rCSI 5.0%PRS 79.2%
-
CSI 5.1rCSI 14.4%PRS 89.9%
-
CSI 5.2rCSI 42.3%PRS 80.1%
-
CSI 5.2rCSI 20.2%PRS 90.7%
-
CSI 5.3rCSI 75.1%PRS 76.5%
-
CSI 5.3rCSI 15.2%PRS 96.9%
-
CSI 5.5rCSI 13.1%PRS 94.5%
-
CSI 5.5rCSI 38.8%PRS 78.1%
-
CSI 5.6rCSI 26.8%PRS 85.0%
-
CSI 5.6rCSI 29.4%PRS 85.6%
-
CSI 5.6rCSI 8.7%PRS 87.5%
-
CSI 5.7rCSI 5.9%PRS 87.7%
-
CSI 5.8rCSI 66.9%PRS 73.2%
-
CSI 5.9rCSI 14.9%PRS 88.6%
-
CSI 5.9rCSI 13.1%PRS 84.7%
-
CSI 6.0rCSI 8.2%PRS 91.4%
-
CSI 6.0rCSI 25.1%PRS 84.5%
-
CSI 6.1rCSI 29.0%PRS 80.9%
-
CSI 6.1rCSI 4.5%PRS 79.4%
-
CSI 6.2rCSI 9.5%PRS 84.8%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3789811429
Symbol: MBD5_HUMAN
Name: Methyl-CpG-binding domain protein 5
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 17847001
Title: Copy-number variations measured by single-nucleotide-polymorphism oligonucleotide arrays in patients with mental retardation.
PubMed ID: 17847001
DOI: 10.1086/521274
PubMed ID: 10819331
Title: Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 10819331
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 12529184
Title: Comparative study of methyl-CpG-binding domain proteins.
PubMed ID: 12529184
PubMed ID: 20700456
Title: The human proteins MBD5 and MBD6 associate with heterochromatin but they do not bind methylated DNA.
PubMed ID: 20700456
PubMed ID: 24634419
Title: MBD5 and MBD6 interact with the human PR-DUB complex through their methyl-CpG-binding domain.
PubMed ID: 24634419
PubMed ID: 36180891
Title: MBD5 and MBD6 stabilize the BAP1 complex and promote BAP1-dependent cancer.
PubMed ID: 36180891
PubMed ID: 22726846
Title: Disruption of an EHMT1-associated chromatin-modification module causes intellectual disability.
PubMed ID: 22726846
Sequence Information:
- Length: 1494
- Mass: 159895
- Checksum: E323E9F6D861E7E9
- Sequence:
MNGGKECDGG DKEGGLPAIQ VPVGWQRRVD QNGVLYVSPS GSLLSCLEQV KTYLLTDGTC KCGLECPLIL PKVFNFDPGA AVKQRTAEDV KADEDVTKLC IHKRKIIAVA TLHKSMEAPH PSLVLTSPGG GTNATPVVPS RAATPRSVRN KSHEGITNSV MPECKNPFKL MIGSSNAMGR LYVQELPGSQ QQELHPVYPR QRLGSSEHGQ KSPFRGSHGG LPSPASSGSQ IYGDGSISPR TDPLGSPDVF TRSNPGFHGA PNSSPIHLNR TPLSPPSVML HGSPVQSSCA MAGRTNIPLS PTLTTKSPVM KKPMCNFSTN MEIPRAMFHH KPPQGPPPPP PPSCALQKKP LTSEKDPLGI LDPIPSKPVN QNPVIINPTS FHSNVHSQVP MMNVSMPPAV VPLPSNLPLP TVKPGHMNHG SHVQRVQHSA STSLSPSPVT SPVHMMGTGI GRIEASPQRS RSSSTSSDHG NFMMPPVGPQ ATSSGIKVPP RSPRSTIGSP RPSMPSSPST KSDGHHQYKD IPNPLIAGIS NVLNTPSSAA FPTASAGSSS VKSQPGLLGM PLNQILNQHN AASFPASSLL SAAAKAQLAN QNKLAGNNSS SSSNSGAVAG SGNTEGHSTL NTMFPPTANM LLPTGEGQSG RAALRDKLMS QQKDALRKRK QPPTTVLSLL RQSQMDSSAV PKPGPDLLRK QGQGSFPISS MSQLLQSMSC QSSHLSSNST PGCGASNTAL PCSANQLHFT DPSMNSSVLQ NIPLRGEAVH CHNANTNFVH SNSPVPNHHL AGLINQIQAS GNCGMLSQSG MALGNSLHPN PPQSRISTSS TPVIPNSIVS SYNQTSSEAG GSGPSSSIAI AGTNHPAITK TTSVLQDGVI VTTAAGNPLQ SQLPIGSDFP FVGQEHALHF PSNSTSNNHL PHPLNPSLLS SLPISLPVNQ QHLLNQNLLN ILQPSAGEGD MSSINNTLSN HQLTHLQSLL NNNQMFPPNQ QQQQLLQGYQ NLQAFQGQST IPCPANNNPM ACLFQNFQVR MQEDAALLNK RISTQPGLTA LPENPNTTLP PFQDTPCELQ PRIDPSLGQQ VKDGLVVGGP GDASVDAIYK AVVDAASKGM QVVITTAVNS TTQISPIPAL SAMSAFTASI GDPLNLSSAV SAVIHGRNMG GVDHDGRLRN SRGARLPKNL DHGKNVNEGD GFEYFKSASC HTSKKQWDGE QSPRGERNRW KYEEFLDHPG HIHSSPCHER PNNVSTLPFL PGEQHPILLP PRNCPGDKIL EENFRYNNYK RTMMSFKERL ENTVERCAHI NGNRPRQSRG FGELLSTAKQ DLVLEEQSPS SSNSLENSLV KDYIHYNGDF NAKSVNGCVP SPSDAKSISS EDDLRNPDSP SSNELIHYRP RTFNVGDLVW GQIKGLTSWP GKLVREDDVH NSCQQSPEEG KVEPEKLKTL TEGLEAYSRV RKRNRKSGKL NNHLEAAIHE AMSELDKMSG TVHQIPQGDR QMRPPKPKRR KISR