Details for: HM13

Gene ID: 81502

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: HM13

Ensembl ID: ENSG00000101294

Description: histocompatibility minor 13

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • plasmablast CL0000980
    CSI 94.21
    rCSI 74.12%
    PRS 24.67
  • plasma cell CL0000786
    CSI 41.81
    rCSI 54.79%
    PRS 68.08
  • pancreatic acinar cell CL0002064
    CSI 37.08
    rCSI 49.28%
    PRS 22.37
  • extravillous trophoblast CL0008036
    CSI 30.08
    rCSI 37.21%
    PRS 17.87
  • glandular epithelial cell CL0000150
    CSI 22.84
    rCSI 60.14%
    PRS 39.34
  • fallopian tube secretory epithelial cell CL4030006
    CSI 22.34
    rCSI 21.5%
    PRS 21.13
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 19
    rCSI 68.39%
    PRS 11.35
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 18.62
    rCSI 14.34%
    PRS 18.94
  • elicited macrophage CL0000861
    CSI 16.93
    rCSI 15.54%
    PRS 23.91
  • granulocyte monocyte progenitor cell CL0000557
    CSI 14.59
    rCSI 12.63%
    PRS 23.04
  • syncytiotrophoblast cell CL0000525
    CSI 14.49
    rCSI 41.74%
    PRS 37.53
  • melanocyte of skin CL1000458
    CSI 14.48
    rCSI 19.73%
    PRS 10.87
  • promonocyte CL0000559
    CSI 14.37
    rCSI 24.61%
    PRS 27.61
  • mucous neck cell CL0000651
    CSI 13.26
    rCSI 19.11%
    PRS 32.11
  • helper T cell CL0000912
    CSI 12.83
    rCSI 18.14%
    PRS 28.17
  • Hofbauer cell CL3000001
    CSI 12.64
    rCSI 23.86%
    PRS 25.8
  • bronchial goblet cell CL1000312
    CSI 12.27
    rCSI 49.04%
    PRS 42.34
  • IgA plasma cell CL0000987
    CSI 11.88
    rCSI 12.17%
    PRS 37.49
  • plasmacytoid dendritic cell, human CL0001058
    CSI 11.34
    rCSI 7.92%
    PRS 21.76
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 10.84
    rCSI 26.35%
    PRS 11.85
  • pancreatic stellate cell CL0002410
    CSI 10.39
    rCSI 60.45%
    PRS 30.16
  • duct epithelial cell CL0000068
    CSI 10.3
    rCSI 15.07%
    PRS 21.63
  • L6b glutamatergic cortical neuron CL4023038
    CSI 10.27
    rCSI 32.09%
    PRS 12.89
  • common myeloid progenitor CL0000049
    CSI 10.04
    rCSI 8.12%
    PRS 20.48
  • regular atrial cardiac myocyte CL0002129
    CSI 9.88
    rCSI 31.82%
    PRS 21.28
  • IgG plasma cell CL0000985
    CSI 9.79
    rCSI 11.73%
    PRS 35.23
  • IgM plasma cell CL0000986
    CSI 9.73
    rCSI 43.77%
    PRS 72.51
  • tracheal goblet cell CL1000329
    CSI 9.22
    rCSI 20.13%
    PRS 39.32
  • dendritic cell, human CL0001056
    CSI 8.77
    rCSI 13.47%
    PRS 24.43
  • basal cell of epidermis CL0002187
    CSI 7.62
    rCSI 13.5%
    PRS 16.37
  • Bergmann glial cell CL0000644
    CSI 7.54
    rCSI 10.32%
    PRS 20.32
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 7.46
    rCSI 43.95%
    PRS 12.64
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 7.3
    rCSI 27.58%
    PRS 12.44
  • CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920
    CSI 6.9
    rCSI 13.76%
    PRS 33.92
  • placental villous trophoblast CL2000060
    CSI 6.84
    rCSI 10.57%
    PRS 19.11
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 6.81
    rCSI 8.25%
    PRS 25.07
  • respiratory goblet cell CL0002370
    CSI 6.66
    rCSI 72.46%
    PRS 38.58
  • intestine goblet cell CL0019031
    CSI 6.51
    rCSI 5.78%
    PRS 20.57
  • hematopoietic stem cell CL0000037
    CSI 6.47
    rCSI 4.3%
    PRS 24.45
  • colon goblet cell CL0009039
    CSI 6.18
    rCSI 14.69%
    PRS 30.31
  • suprabasal keratinocyte CL4033013
    CSI 6.09
    rCSI 9.94%
    PRS 11.67
  • mesodermal cell CL0000222
    CSI 6
    rCSI 7.2%
    PRS 19.91
  • peptic cell CL0000155
    CSI 5.9
    rCSI 58.01%
    PRS 51.73
  • vascular leptomeningeal cell CL4023051
    CSI 5.9
    rCSI 10.34%
    PRS 15.5
  • mammary gland epithelial cell CL0002327
    CSI 5.87
    rCSI 20.61%
    PRS 35.17
  • small intestine goblet cell CL1000495
    CSI 5.87
    rCSI 12.86%
    PRS 27.27
  • pro-B cell CL0000826
    CSI 5.85
    rCSI 4.84%
    PRS 20.72
  • hepatocyte CL0000182
    CSI 5.71
    rCSI 10.22%
    PRS 18.89
  • club cell CL0000158
    CSI 5.62
    rCSI 8.23%
    PRS 23.36
  • antibody secreting cell CL0000946
    CSI 5.58
    rCSI 24.81%
    PRS 69.1
  • double negative thymocyte CL0002489
    CSI 5.17
    rCSI 3.6%
    PRS 24.41
  • effector CD8-positive, alpha-beta T cell CL0001050
    CSI 5.07
    rCSI 3.85%
    PRS 26.93
  • pancreatic ductal cell CL0002079
    CSI 5.02
    rCSI 9.76%
    PRS 20.88
  • corneal epithelial cell CL0000575
    CSI 5.01
    rCSI 14.34%
    PRS 35.68
  • myeloid lineage restricted progenitor cell CL0000839
    CSI 4.78
    rCSI 24.67%
    PRS 39.5
  • epithelial cell of lung CL0000082
    CSI 4.75
    rCSI 3.94%
    PRS 19.32
  • respiratory epithelial cell CL0002368
    CSI 4.61
    rCSI 28.49%
    PRS 59.09
  • colon epithelial cell CL0011108
    CSI 4.56
    rCSI 4.78%
    PRS 19.03
  • alternatively activated macrophage CL0000890
    CSI 4.55
    rCSI 5.72%
    PRS 31.28
  • multi-ciliated epithelial cell CL0005012
    CSI 4.45
    rCSI 4.44%
    PRS 17.42
  • basal cell CL0000646
    CSI 4.43
    rCSI 5.92%
    PRS 22.37
  • muscle cell CL0000187
    CSI 4.34
    rCSI 8.92%
    PRS 43.48
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 4.31
    rCSI 3.9%
    PRS 18.4
  • renal alpha-intercalated cell CL0005011
    CSI 4.07
    rCSI 5.44%
    PRS 26.47
  • CD14-positive, CD16-negative classical monocyte CL0002057
    CSI 4.07
    rCSI 24.6%
    PRS 44.35
  • naive T cell CL0000898
    CSI 4.05
    rCSI 2.82%
    PRS 28.78
  • tracheobronchial serous cell CL0019001
    CSI 3.79
    rCSI 16.37%
    PRS 37.21
  • serous secreting cell of bronchus submucosal gland CL4033005
    CSI 3.66
    rCSI 20.81%
    PRS 59.87
  • foveolar cell of stomach CL0002179
    CSI 3.62
    rCSI 7.7%
    PRS 32.32
  • effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062
    CSI 3.6
    rCSI 18.08%
    PRS 26.93
  • myelocyte CL0002193
    CSI 3.56
    rCSI 23.37%
    PRS 58.1
  • intestinal epithelial cell CL0002563
    CSI 3.46
    rCSI 3.61%
    PRS 21.3
  • interstitial cell of Cajal CL0002088
    CSI 3.42
    rCSI 4.35%
    PRS 23.69
  • glutamatergic neuron CL0000679
    CSI 3.37
    rCSI 6.93%
    PRS 20.22
  • acinar cell of salivary gland CL0002623
    CSI 3.33
    rCSI 77.6%
    PRS 37.81
  • microcirculation associated smooth muscle cell CL0008035
    CSI 3.33
    rCSI 9.63%
    PRS 23.03
  • central memory CD8-positive, alpha-beta T cell CL0000907
    CSI 3.22
    rCSI 2.17%
    PRS 25.03
  • chondrocyte CL0000138
    CSI 3.16
    rCSI 5.02%
    PRS 17.22
  • pancreatic A cell CL0000171
    CSI 3.16
    rCSI 3.31%
    PRS 21.74
  • fraction A pre-pro B cell CL0002045
    CSI 3.04
    rCSI 3.48%
    PRS 40.99
  • effector memory CD4-positive, alpha-beta T cell CL0000905
    CSI 3
    rCSI 4.08%
    PRS 46.71
  • pancreatic D cell CL0000173
    CSI 2.95
    rCSI 2.91%
    PRS 22.03
  • CD16-negative, CD56-bright natural killer cell, human CL0000938
    CSI 2.9
    rCSI 2.17%
    PRS 54.2
  • melanocyte CL0000148
    CSI 2.88
    rCSI 2.13%
    PRS 17.72
  • stem cell CL0000034
    CSI 2.85
    rCSI 2.75%
    PRS 14.75
  • direct pathway medium spiny neuron CL4023026
    CSI 2.82
    rCSI 67.57%
    PRS 10.48
  • Langerhans cell CL0000453
    CSI 2.79
    rCSI 4.26%
    PRS 35.57
  • GABAergic neuron CL0000617
    CSI 2.78
    rCSI 9.33%
    PRS 14.55
  • goblet cell CL0000160
    CSI 2.78
    rCSI 2.63%
    PRS 21.42
  • indirect pathway medium spiny neuron CL4023029
    CSI 2.77
    rCSI 66.73%
    PRS 11.44
  • non-classical monocyte CL0000875
    CSI 2.74
    rCSI 4.38%
    PRS 53.71
  • double-positive, alpha-beta thymocyte CL0000809
    CSI 2.73
    rCSI 2.79%
    PRS 29.16
  • group 3 innate lymphoid cell CL0001071
    CSI 2.73
    rCSI 2.05%
    PRS 21.68
  • P/D1 enteroendocrine cell CL0002268
    CSI 2.71
    rCSI 14.78%
    PRS 46.25
  • brush cell of tracheobronchial tree CL0002075
    CSI 2.71
    rCSI 8.04%
    PRS 28.64
  • eosinophil CL0000771
    CSI 2.7
    rCSI 17.69%
    PRS 50.27
  • skin fibroblast CL0002620
    CSI 2.67
    rCSI 2.31%
    PRS 31.54
  • myofibroblast cell CL0000186
    CSI 2.66
    rCSI 3.68%
    PRS 28.78
  • unswitched memory B cell CL0000970
    CSI 2.63
    rCSI 2.21%
    PRS 32.18
  • pulmonary capillary endothelial cell CL4028001
    CSI 2.54
    rCSI 4.84%
    PRS 32.05
  • sst GABAergic cortical interneuron CL4023017
    CSI -2.3
    rCSI -3.0%
    PRS 12.7%
  • renal beta-intercalated cell CL0002201
    CSI -1.2
    rCSI -2.8%
    PRS 23.4%
  • deuterosomal cell CL4033044
    CSI -0.8
    rCSI -2.6%
    PRS 32.3%
  • CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792
    CSI -0.6
    rCSI -0.6%
    PRS 31.6%
  • effector CD4-positive, alpha-beta T cell CL0001044
    CSI -0.5
    rCSI -1.5%
    PRS 30.4%
  • tracheobronchial smooth muscle cell CL0019019
    CSI -0.2
    rCSI -0.4%
    PRS 26.7%
  • megakaryocyte progenitor cell CL0000553
    CSI 0.1
    rCSI 1.9%
    PRS 55.8%
  • regular ventricular cardiac myocyte CL0002131
    CSI 0.1
    rCSI 0.7%
    PRS 15.9%
  • vein endothelial cell of respiratory system CL4033008
    CSI 0.1
    rCSI 0.8%
    PRS 39.1%
  • cerebral cortex pyramidal neuron CL4023111
    CSI 0.1
    rCSI 0.8%
    PRS 49.1%
  • prostate gland microvascular endothelial cell CL2000059
    CSI 0.1
    rCSI 3.5%
    PRS 57.7%
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 0.2
    rCSI 0.3%
    PRS 12.0%
  • stromal cell of ovary CL0002132
    CSI 0.2
    rCSI 0.4%
    PRS 33.4%
  • parietal epithelial cell CL1000452
    CSI 0.2
    rCSI 0.6%
    PRS 17.0%
  • GABAergic interneuron CL0011005
    CSI 0.2
    rCSI 3.6%
    PRS 18.6%
  • retinal bipolar neuron CL0000748
    CSI 0.2
    rCSI 0.4%
    PRS 14.7%
  • intestinal tuft cell CL0019032
    CSI 0.2
    rCSI 0.4%
    PRS 23.3%
  • type L enteroendocrine cell CL0002279
    CSI 0.3
    rCSI 0.5%
    PRS 39.6%
  • pre-conventional dendritic cell CL0002010
    CSI 0.3
    rCSI 3.5%
    PRS 57.5%
  • basal-myoepithelial cell of mammary gland CL0002324
    CSI 0.3
    rCSI 0.5%
    PRS 42.8%
  • kidney connecting tubule epithelial cell CL1000768
    CSI 0.3
    rCSI 0.7%
    PRS 15.5%
  • transit amplifying cell of colon CL0009011
    CSI 0.3
    rCSI 0.4%
    PRS 23.6%
  • mature B cell CL0000785
    CSI 0.3
    rCSI 0.3%
    PRS 25.6%
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 0.3
    rCSI 0.7%
    PRS 13.3%
  • group 2 innate lymphoid cell CL0001069
    CSI 0.3
    rCSI 1.7%
    PRS 61.6%
  • basal cell of epithelium of trachea CL1000348
    CSI 0.3
    rCSI 2.4%
    PRS 54.3%
  • CD8-positive, alpha-beta cytotoxic T cell CL0000794
    CSI 0.3
    rCSI 0.4%
    PRS 35.3%
  • CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human CL0001074
    CSI 0.3
    rCSI 4.0%
    PRS 66.2%
  • mesenchymal stem cell CL0000134
    CSI 0.4
    rCSI 3.8%
    PRS 36.0%
  • contractile cell CL0000183
    CSI 0.4
    rCSI 1.1%
    PRS 19.4%
  • enterocyte of epithelium of small intestine CL1000334
    CSI 0.4
    rCSI 5.9%
    PRS 48.4%
  • retinal pigment epithelial cell CL0002586
    CSI 0.4
    rCSI 0.8%
    PRS 21.5%
  • amacrine cell CL0000561
    CSI 0.4
    rCSI 1.1%
    PRS 15.7%
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 0.4
    rCSI 1.2%
    PRS 26.4%
  • dopaminergic neuron CL0000700
    CSI 0.4
    rCSI 2.4%
    PRS 11.5%
  • retina horizontal cell CL0000745
    CSI 0.4
    rCSI 0.7%
    PRS 19.0%
  • hematopoietic multipotent progenitor cell CL0000837
    CSI 0.4
    rCSI 1.1%
    PRS 32.4%
  • pulmonary ionocyte CL0017000
    CSI 0.4
    rCSI 0.5%
    PRS 25.5%
  • retinal ganglion cell CL0000740
    CSI 0.5
    rCSI 1.0%
    PRS 14.6%
  • mesenchymal lymphangioblast CL0005021
    CSI 0.5
    rCSI 11.9%
    PRS 70.0%
  • serotonergic neuron CL0000850
    CSI 0.5
    rCSI 2.1%
    PRS 13.3%
  • peripheral nervous system neuron CL2000032
    CSI 0.5
    rCSI 0.7%
    PRS 18.1%
  • neuroendocrine cell CL0000165
    CSI 0.5
    rCSI 1.9%
    PRS 39.7%
  • serous secreting cell CL0000313
    CSI 0.5
    rCSI 2.5%
    PRS 64.2%
  • erythroblast CL0000765
    CSI 0.5
    rCSI 1.3%
    PRS 32.2%
  • thymocyte CL0000893
    CSI 0.5
    rCSI 1.8%
    PRS 58.9%
  • VIP GABAergic cortical interneuron CL4023016
    CSI 0.5
    rCSI 0.6%
    PRS 11.9%
  • cardiac neuron CL0010022
    CSI 0.5
    rCSI 1.7%
    PRS 16.4%
  • erythroid progenitor cell CL0000038
    CSI 0.5
    rCSI 3.0%
    PRS 30.6%
  • transit amplifying cell CL0009010
    CSI 0.5
    rCSI 0.8%
    PRS 32.9%
  • lung ciliated cell CL1000271
    CSI 0.5
    rCSI 0.6%
    PRS 15.0%
  • podocyte CL0000653
    CSI 0.5
    rCSI 2.4%
    PRS 20.0%
  • primitive red blood cell CL0002355
    CSI 0.6
    rCSI 3.0%
    PRS 35.3%
  • lymphoid lineage restricted progenitor cell CL0000838
    CSI 0.6
    rCSI 2.3%
    PRS 33.4%
  • squamous epithelial cell CL0000076
    CSI 0.6
    rCSI 1.4%
    PRS 25.2%
  • ON parasol ganglion cell CL4033052
    CSI 0.6
    rCSI 8.7%
    PRS 15.7%
  • neural progenitor cell CL0011020
    CSI 0.6
    rCSI 2.7%
    PRS 19.2%
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 0.6
    rCSI 1.4%
    PRS 21.1%
  • natural T-regulatory cell CL0000903
    CSI 0.6
    rCSI 1.2%
    PRS 52.6%
  • intestinal crypt stem cell of colon CL0009043
    CSI 0.6
    rCSI 4.8%
    PRS 37.1%
  • BEST4+ enteroycte CL4030026
    CSI 0.7
    rCSI 0.8%
    PRS 21.7%
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 0.7
    rCSI 2.1%
    PRS 13.9%
  • sncg GABAergic cortical interneuron CL4023015
    CSI 0.7
    rCSI 1.1%
    PRS 13.2%
  • stromal cell CL0000499
    CSI 0.7
    rCSI 1.9%
    PRS 27.3%
  • alpha-beta T cell CL0000789
    CSI 0.7
    rCSI 0.8%
    PRS 28.0%
  • endothelial cell of uterus CL0009095
    CSI 0.7
    rCSI 5.0%
    PRS 52.5%
  • innate lymphoid cell CL0001065
    CSI 0.7
    rCSI 1.5%
    PRS 30.2%
  • pancreatic PP cell CL0002275
    CSI 0.7
    rCSI 3.0%
    PRS 34.7%
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 0.8
    rCSI 1.3%
    PRS 12.1%
  • myeloid dendritic cell CL0000782
    CSI 0.8
    rCSI 1.1%
    PRS 30.7%
  • renal interstitial pericyte CL1001318
    CSI 0.8
    rCSI 2.1%
    PRS 19.0%
  • T-helper 17 cell CL0000899
    CSI 0.8
    rCSI 0.6%
    PRS 36.2%
  • keratinocyte CL0000312
    CSI 0.8
    rCSI 0.7%
    PRS 24.3%
  • endocardial cell CL0002350
    CSI 0.8
    rCSI 3.9%
    PRS 25.2%
  • CD4-positive, alpha-beta cytotoxic T cell CL0000934
    CSI 0.8
    rCSI 1.1%
    PRS 39.8%
  • pulmonary alveolar type 1 cell CL0002062
    CSI 0.8
    rCSI 4.7%
    PRS 25.9%
  • retinal blood vessel endothelial cell CL0002585
    CSI 0.8
    rCSI 1.3%
    PRS 22.3%
  • class switched memory B cell CL0000972
    CSI 0.8
    rCSI 0.6%
    PRS 34.2%
  • Kupffer cell CL0000091
    CSI 0.8
    rCSI 1.9%
    PRS 19.9%
  • colon macrophage CL0009038
    CSI 0.8
    rCSI 3.9%
    PRS 42.0%
  • fibroblast of cardiac tissue CL0002548
    CSI 0.8
    rCSI 4.0%
    PRS 16.1%
  • cerebellar granule cell CL0001031
    CSI 0.9
    rCSI 1.3%
    PRS 18.8%
  • glioblast CL0000030
    CSI 0.9
    rCSI 1.4%
    PRS 17.5%
  • OFF midget ganglion cell CL4033047
    CSI 0.9
    rCSI 17.6%
    PRS 17.6%
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 0.9
    rCSI 1.1%
    PRS 24.5%
  • osteoblast CL0000062
    CSI 0.9
    rCSI 21.6%
    PRS 82.6%
  • luminal epithelial cell of mammary gland CL0002326
    CSI 0.9
    rCSI 1.6%
    PRS 31.1%
  • respiratory basal cell CL0002633
    CSI 0.9
    rCSI 0.9%
    PRS 24.0%
  • conjunctival epithelial cell CL1000432
    CSI 0.9
    rCSI 1.4%
    PRS 20.5%
  • colonocyte CL1000347
    CSI 0.9
    rCSI 1.3%
    PRS 27.5%
  • retinal cone cell CL0000573
    CSI 0.9
    rCSI 1.5%
    PRS 15.6%
  • glycinergic amacrine cell CL4030028
    CSI 0.9
    rCSI 2.5%
    PRS 20.5%
  • mesenchymal cell CL0008019
    CSI 1.0
    rCSI 2.4%
    PRS 20.5%
  • granulocyte CL0000094
    CSI 1.0
    rCSI 1.5%
    PRS 26.4%
  • periportal region hepatocyte CL0019026
    CSI 1.0
    rCSI 3.8%
    PRS 27.8%
  • retinal rod cell CL0000604
    CSI 1.0
    rCSI 1.7%
    PRS 19.9%
  • kidney epithelial cell CL0002518
    CSI 1.0
    rCSI 1.9%
    PRS 44.0%
  • inflammatory macrophage CL0000863
    CSI 1.0
    rCSI 1.7%
    PRS 40.8%
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 1.0
    rCSI 2.2%
    PRS 14.5%
  • alveolar type 1 fibroblast cell CL4028004
    CSI 1.0
    rCSI 1.1%
    PRS 23.0%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [HM13](/details-gene/81502), also known as histocompatibility minor 13, encodes an intramembrane aspartic protease called signal peptide peptidase (SPP) [Link](https://doi.org/10.1126/science.1070925). This enzyme is primarily localized to the endoplasmic reticulum membrane where it plays a critical role in protein quality control and immune surveillance. Its main function is to cleave signal peptides after they have been removed from nascent proteins, a process essential for clearing the translocation channel and for generating specific peptide epitopes for presentation by MHC class I molecules [Link](https://doi.org/10.4049/jimmunol.167.11.6441). The expression profile of [HM13](/details-gene/81502) is marked by exceptionally high significance in professional secretory cells, most notably immune cells such as [plasmablast](/details-cell/CL0000980)s and [plasma cell](/details-cell/CL0000786)s, as well as various glandular and trophoblastic cells. This pattern underscores its fundamental importance in managing the high protein flux associated with robust secretory activity. ## Cellular Roles and Expression Landscape **Overall**, the expression landscape of [HM13](/details-gene/81502) highlights its indispensable function in cells characterized by a high rate of protein synthesis and secretion. Its significance is highest by a substantial margin in cells of the B lymphocyte lineage committed to antibody production, including [plasmablast](/details-cell/CL0000980) (CSI: 94.21) and [plasma cell](/details-cell/CL0000786) (CSI: 41.81). Significant expression is also observed in myeloid lineage cells like [CD14-low, CD16-positive monocyte](/details-cell/CL0002396)s and [elicited macrophage](/details-cell/CL0000861)s, suggesting a broad role in immune cell function beyond the adaptive response. Beyond the immune system, [HM13](/details-gene/81502) is a prominent marker in other highly active secretory tissues. These include [pancreatic acinar cell](/details-cell/CL0002064)s, [extravillous trophoblast](/details-cell/CL0008036)s, [syncytiotrophoblast cell](/details-cell/CL0000525)s, and various [glandular epithelial cell](/details-cell/CL0000150)s. This widespread but specific expression pattern points to a vital housekeeping role in maintaining endoplasmic reticulum homeostasis, a function that becomes particularly critical under the high proteotoxic stress experienced by these cell types. Conversely, its notably low significance in cells such as [sst GABAergic cortical interneuron](/details-cell/CL4023017) and specific lymphocyte subsets like [CD4-positive, CD25-positive, alpha-beta regulatory T cell](/details-cell/CL0000792) suggests its function is less central in cells with lower secretory burdens or distinct protein processing pathways. ## Pathways and Molecular Function Functionally, [HM13](/details-gene/81502) is an intramembrane protease with a catalytic mechanism defined by its [aspartic endopeptidase activity, intramembrane cleaving](/details-link/GO:0042500) annotation. Its principal biological process is [signal peptide processing](/details-link/GO:0006465), which occurs within the [endoplasmic reticulum membrane](/details-link/GO:0005789). This activity is crucial for ER-associated degradation (ERAD) and the prevention of clogged protein translocons. The protein's function is also linked to the ubiquitin-proteasome system through its ability to bind ubiquitin protein ligases ([ubiquitin protein ligase binding](/details-link/GO:0031625)), which may facilitate the removal of aberrant proteins from the ER [Link](https://doi.org/10.1083/jcb.200906110). The immunological relevance of [HM13](/details-gene/81502) stems directly from its proteolytic function. By processing certain signal peptides, it generates epitopes that are loaded onto non-classical MHC molecules, thereby playing a role in immune surveillance [Link](https://doi.org/10.4049/jimmunol.167.11.6441). Furthermore, its association with Reactome pathways such as [Cellular responses to stress](/details-link/R-HSA-2262752) and the GO term [cellular response to oxidative stress](/details-link/GO:0034599) indicates its role in maintaining cellular health under adverse conditions, a state frequently encountered by the highly metabolic cells in which it is most active. ## Research Directions The dual role of [HM13](/details-gene/81502) in managing secretory stress and contributing to immune antigen processing opens several avenues for future investigation. 1. **Hypothesis 1:** Given its exceptional expression in [plasmablast](/details-cell/CL0000980)s and its function in ER homeostasis, the activity of [HM13](/details-gene/81502) may act as a critical regulatory checkpoint during plasma cell differentiation. Its inhibition or downregulation could lead to overwhelming ER stress, triggering apoptosis and impairing antibody production, a mechanism that might be relevant in certain immunodeficiencies or plasma cell malignancies like multiple myeloma. 2. **Hypothesis 2:** The established role of [HM13](/details-gene/81502) in processing the hepatitis C virus core protein [Link](https://doi.org/10.1093/emboj/cdf414) suggests it may be a broader host dependency factor for viruses that utilize the ER for protein maturation. It could be co-opted by various pathogens to facilitate viral protein trafficking or to modulate the host immune response by altering the repertoire of presented peptide antigens. A key experiment to test the first hypothesis would involve the use of a B cell-specific conditional knockout mouse model for [HM13](/details-gene/81502). Following immunization, B cells lacking the gene could be analyzed for their capacity to differentiate into functional plasma cells. A combination of flow cytometry to track differentiation, ELISpot assays to quantify antibody secretion, and transcriptomic/proteomic analyses to measure ER stress markers would provide a comprehensive assessment of its role in humoral immunity. From a therapeutic standpoint, [HM13](/details-gene/81502) is an attractive drug target due to its enzymatic nature. **Inhibition** of its protease activity could be a viable strategy for treating diseases driven by malignant plasma cells, such as multiple myeloma. These cancer cells operate under immense proteotoxic stress, and further compromising their ER protein processing capacity could selectively induce cell death. However, the importance of [HM13](/details-gene/81502) in other vital secretory cells, such as those in the pancreas, raises potential concerns about on-target toxicity, suggesting that targeted drug delivery systems may be required for clinical application.

Genular Protein ID: 2272685438

Symbol: HM13_HUMAN

Name: Minor histocompatibility antigen H13

UniProtKB Accession Codes:

Q8TCT9 B2RAY5 E1P5L3 Q15K36 Q540H8 Q5JWP2 Q5JWP3 Q5JWP4 Q5JWP5 Q7Z4F2 Q86Y35 Q95H87 Q9H110 Q9H111

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CPTAC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 21 Ensembl 3 ExpressionAtlas 1 GO 18 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SMART 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12077416

Title: Identification of signal peptide peptidase, a presenilin-type aspartic protease.

PubMed ID: 12077416

DOI: 10.1126/science.1070925

PubMed ID: 12972007

Title: Expression of the presenilin-like signal peptide peptidase (SPP) in mouse adult brain and during development.

PubMed ID: 12972007

DOI: 10.1016/s1567-133x(03)00094-2

PubMed ID: 12139484

Title: Novel class of polytopic proteins with domains associated with putative protease activity.

PubMed ID: 12139484

DOI: 10.1023/a:1016365227942

PubMed ID: 16730383

Title: Cell-surface expression of a new splice variant of the mouse signal peptide peptidase.

PubMed ID: 16730383

DOI: 10.1016/j.bbaexp.2006.02.007

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11714810

Title: Intramembrane proteolysis of signal peptides: an essential step in the generation of HLA-E epitopes.

PubMed ID: 11714810

DOI: 10.4049/jimmunol.167.11.6441

PubMed ID: 12145199

Title: Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets.

PubMed ID: 12145199

DOI: 10.1093/emboj/cdf414

PubMed ID: 14741365

Title: Impas 1 possesses endoproteolytic activity against multipass membrane protein substrate cleaving the presenilin 1 holoprotein.

PubMed ID: 14741365

DOI: 10.1016/s0014-5793(03)01489-3

PubMed ID: 15385547

Title: Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins.

PubMed ID: 15385547

DOI: 10.1074/jbc.m407898200

PubMed ID: 15998642

Title: Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3.

PubMed ID: 15998642

DOI: 10.1074/jbc.m501645200

PubMed ID: 19720873

Title: The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER.

PubMed ID: 19720873

DOI: 10.1083/jcb.200906110

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25239945

Title: Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u.

PubMed ID: 25239945

DOI: 10.15252/embj.201488208

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 377
  • Mass: 41488
  • Checksum: 322D231B52B33118
  • Sequence:
    • MDSALSDPHN GSAEAGGPTN STTRPPSTPE GIALAYGSLL LMALLPIFFG ALRSVRCARG 
KNASDMPETI TSRDAARFPI IASCTLLGLY LFFKIFSQEY INLLLSMYFF VLGILALSHT 
ISPFMNKFFP ASFPNRQYQL LFTQGSGENK EEIINYEFDT KDLVCLGLSS IVGVWYLLRK 
HWIANNLFGL AFSLNGVELL HLNNVSTGCI LLGGLFIYDV FWVFGTNVMV TVAKSFEAPI 
KLVFPQDLLE KGLEANNFAM LGLGDVVIPG IFIALLLRFD ISLKKNTHTY FYTSFAAYIF 
GLGLTIFIMH IFKHAQPALL YLVPACIGFP VLVALAKGEV TEMFSYEESN PKDPAAVTES 
KEGTEASASK GLEKKEK

Genular Protein ID: 3160875543

Symbol: A0A0C4DGU3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0C4DGU3

Database IDs:

ARBA 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 3 GO 2 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 2 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 143
  • Mass: 15432
  • Checksum: 50B62E336B6AB930
  • Sequence:
    • MDSALSDPHN GSAEAGGPTN STTRPPSTPE GIALAYGSLL LMALLPIFFG ALRSVRCARG 
KNASDMPETI TSRDAARFPI IASCTLLGLY LFFKIFSQEY INLLLSMYFF VLGILALSHT 
IRSEGISLQH LKQLSREPVQ GLG