Details for: NPC2
Gene ID: 10577
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: NPC2
Ensembl ID: ENSG00000119655
Description: NPC intracellular cholesterol transporter 2
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 105.49rCSI 73.65%PRS 10.79
-
CSI 103.47rCSI 95%PRS 11.74
-
CSI 93.79rCSI 72.26%PRS 9.29
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CSI 84.01rCSI 65.13%PRS 9.79
-
CSI 70.3rCSI 73.47%PRS 10.85
-
CSI 67.41rCSI 62.2%PRS 10.42
-
CSI 65.99rCSI 86.46%PRS 14.36
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CSI 62.14rCSI 78.12%PRS 15.71
-
CSI 61.76rCSI 74.6%PRS 12.07
-
CSI 58.1rCSI 90.12%PRS 15.83
-
CSI 57.18rCSI 47.93%PRS 12.29
-
CSI 52.64rCSI 55.14%PRS 9.55
-
CSI 51.83rCSI 64.11%PRS 9.02
-
CSI 51.11rCSI 49.28%PRS 6.85
-
CSI 48.59rCSI 80.02%PRS 12.02
-
CSI 46.8rCSI 38.03%PRS 10.88
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CSI 45.26rCSI 37.52%PRS 9.71
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CSI 43.2rCSI 41.59%PRS 10.61
-
CSI 43.14rCSI 81.45%PRS 12.74
-
CSI 42.54rCSI 68.19%PRS 32.31
-
CSI 42.02rCSI 44.65%PRS 18.29
-
CSI 41.15rCSI 41.68%PRS 54.44
-
CSI 40.12rCSI 29.72%PRS 9.23
-
CSI 39.83rCSI 59.05%PRS 67.08
-
CSI 36.52rCSI 38.26%PRS 10.96
-
CSI 34.97rCSI 63.61%PRS 41.69
-
CSI 34.32rCSI 49.46%PRS 16.54
-
CSI 33.42rCSI 39.25%PRS 12.19
-
CSI 33.16rCSI 50.03%PRS 10.13
-
CSI 32.62rCSI 55.75%PRS 20.8
-
CSI 32.14rCSI 26.83%PRS 30.81
-
CSI 32.1rCSI 31.58%PRS 11.18
-
CSI 31.25rCSI 68.8%PRS 11.31
-
CSI 30.17rCSI 51.69%PRS 13.75
-
CSI 30.04rCSI 67.1%PRS 11.64
-
CSI 29.97rCSI 46.02%PRS 11.99
-
CSI 27.34rCSI 40.05%PRS 12
-
CSI 26.69rCSI 32.89%PRS 33.22
-
CSI 26.17rCSI 23.01%PRS 7.45
-
CSI 26.04rCSI 37.73%PRS 15.15
-
CSI 25.48rCSI 25.42%PRS 8.82
-
CSI 25.09rCSI 57.37%PRS 9.95
-
CSI 24.59rCSI 30.86%PRS 13.11
-
CSI 24.08rCSI 45.97%PRS 24.47
-
CSI 23.46rCSI 37.82%PRS 16.45
-
CSI 22.68rCSI 19.55%PRS 16.77
-
CSI 22.49rCSI 40.65%PRS 28.06
-
CSI 22.06rCSI 25.51%PRS 7.53
-
CSI 21.96rCSI 20.44%PRS 10.34
-
CSI 21.74rCSI 59.73%PRS 17.05
-
CSI 20.68rCSI 31.78%PRS 14.67
-
CSI 20.5rCSI 31.35%PRS 16.69
-
CSI 20.09rCSI 25.03%PRS 14.67
-
CSI 19.68rCSI 90.88%PRS 21.74
-
CSI 19.21rCSI 17.05%PRS 10.28
-
CSI 18.35rCSI 44.12%PRS 15.55
-
CSI 18.29rCSI 19.6%PRS 9.43
-
CSI 18.12rCSI 24.09%PRS 11.2
-
CSI 17.14rCSI 17.76%PRS 12.08
-
CSI 17.12rCSI 16.18%PRS 10.72
-
CSI 17.06rCSI 38.3%PRS 21.91
-
CSI 17.04rCSI 67.83%PRS 18.04
-
CSI 16.96rCSI 49.06%PRS 22.9
-
CSI 16.88rCSI 19.58%PRS 15.22
-
CSI 16.86rCSI 24.73%PRS 13.49
-
CSI 16.72rCSI 20.03%PRS 17.67
-
CSI 16.67rCSI 17.06%PRS 19.22
-
CSI 16.36rCSI 67.38%PRS 37.43
-
CSI 16.05rCSI 25.34%PRS 10.27
-
CSI 15.9rCSI 20.84%PRS 46.04
-
CSI 15.69rCSI 73.14%PRS 24.96
-
CSI 15.01rCSI 15.66%PRS 10.54
-
CSI 14.98rCSI 33.16%PRS 9.54
-
CSI 14.94rCSI 22.82%PRS 17.94
-
CSI 14.93rCSI 22.81%PRS 10.3
-
CSI 14.86rCSI 19.87%PRS 11.22
-
CSI 14.37rCSI 32.8%PRS 9.16
-
CSI 14.28rCSI 9.49%PRS 12.25
-
CSI 14.27rCSI 18.31%PRS 11.85
-
CSI 13.98rCSI 18.69%PRS 13.69
-
CSI 13.92rCSI 20.07%PRS 14.3
-
CSI 13.76rCSI 80.09%PRS 15.43
-
CSI 13.62rCSI 82.38%PRS 23.12
-
CSI 13.57rCSI 19.47%PRS 8.16
-
CSI 13.55rCSI 20.71%PRS 12.96
-
CSI 13.38rCSI 19.18%PRS 14.11
-
CSI 13.34rCSI 19.54%PRS 49.54
-
CSI 13.21rCSI 11.44%PRS 11.44
-
CSI 13.12rCSI 19.2%PRS 10.87
-
CSI 13.04rCSI 35.6%PRS 41.41
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CSI 12.5rCSI 29.72%PRS 15.45
-
CSI 12.32rCSI 9.69%PRS 12.18
-
CSI 12.29rCSI 16.73%PRS 15.76
-
CSI 11.84rCSI 15.15%PRS 42.28
-
CSI 11.71rCSI 11.56%PRS 40.22
-
CSI 11.66rCSI 16.15%PRS 14.81
-
CSI 11.23rCSI 24.52%PRS 20.78
-
CSI 11.12rCSI 26.55%PRS 16.2
-
CSI 10.9rCSI 9.57%PRS 11.54
-
CSI 10.8rCSI 19.26%PRS 17.48
-
CSI -13.9rCSI -11.2%PRS 18.6%
-
CSI -11.4rCSI -7.9%PRS 12.0%
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CSI -6.3rCSI -6.2%PRS 16.2%
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CSI -4.6rCSI -15.0%PRS 12.6%
-
CSI -3.9rCSI -8.8%PRS 6.3%
-
CSI -3.9rCSI -2.7%PRS 14.6%
-
CSI -3.8rCSI -7.8%PRS 15.9%
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CSI -3.2rCSI -6.0%PRS 16.5%
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CSI -3.1rCSI -9.0%PRS 14.9%
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CSI -2.7rCSI -5.4%PRS 17.1%
-
CSI -2.5rCSI -47.6%PRS 64.0%
-
CSI -2.4rCSI -10.6%PRS 10.1%
-
CSI -2.0rCSI -1.5%PRS 14.0%
-
CSI -1.9rCSI -1.4%PRS 17.2%
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CSI -1.6rCSI -2.7%PRS 7.8%
-
CSI -1.4rCSI -1.0%PRS 10.6%
-
CSI -0.6rCSI -1.5%PRS 13.1%
-
CSI -0.6rCSI -0.8%PRS 9.2%
-
CSI -0.2rCSI -1.2%PRS 22.7%
-
CSI -0.1rCSI -0.3%PRS 23.4%
-
CSI 0.2rCSI 3.2%PRS 52.9%
-
CSI 0.2rCSI 0.8%PRS 14.0%
-
CSI 0.3rCSI 0.4%PRS 14.6%
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CSI 0.3rCSI 1.7%PRS 40.9%
-
CSI 0.3rCSI 2.0%PRS 26.7%
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CSI 0.3rCSI 1.2%PRS 41.4%
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CSI 0.4rCSI 6.0%PRS 41.6%
-
CSI 0.4rCSI 2.0%PRS 15.1%
-
CSI 0.4rCSI 2.1%PRS 44.2%
-
CSI 0.4rCSI 1.9%PRS 14.0%
-
CSI 0.4rCSI 1.1%PRS 18.6%
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CSI 0.4rCSI 8.4%PRS 33.5%
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CSI 0.5rCSI 1.5%PRS 6.5%
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CSI 0.5rCSI 1.7%PRS 32.3%
-
CSI 0.5rCSI 1.7%PRS 29.8%
-
CSI 0.6rCSI 14.4%PRS 48.7%
-
CSI 0.6rCSI 2.5%PRS 41.7%
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CSI 0.6rCSI 0.7%PRS 17.8%
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CSI 0.7rCSI 1.1%PRS 9.6%
-
CSI 0.8rCSI 1.6%PRS 23.0%
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CSI 0.8rCSI 3.3%PRS 21.5%
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CSI 0.9rCSI 1.6%PRS 28.3%
-
CSI 0.9rCSI 0.6%PRS 12.3%
-
CSI 1.0rCSI 4.8%PRS 13.4%
-
CSI 1.0rCSI 2.8%PRS 20.2%
-
CSI 1.1rCSI 1.2%PRS 21.1%
-
CSI 1.1rCSI 15.1%PRS 33.8%
-
CSI 1.2rCSI 2.5%PRS 15.7%
-
CSI 1.2rCSI 8.0%PRS 58.3%
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CSI 1.2rCSI 5.6%PRS 30.5%
-
CSI 1.3rCSI 10.9%PRS 53.7%
-
CSI 1.3rCSI 2.7%PRS 7.6%
-
CSI 1.3rCSI 7.3%PRS 19.2%
-
CSI 1.4rCSI 3.7%PRS 17.2%
-
CSI 1.4rCSI 3.1%PRS 7.4%
-
CSI 1.4rCSI 2.8%PRS 27.9%
-
CSI 1.4rCSI 43.3%PRS 23.9%
-
CSI 1.5rCSI 22.6%PRS 25.6%
-
CSI 1.5rCSI 5.4%PRS 41.2%
-
CSI 1.5rCSI 35.1%PRS 18.0%
-
CSI 1.5rCSI 3.3%PRS 13.8%
-
CSI 1.5rCSI 32.5%PRS 63.8%
-
CSI 1.6rCSI 10.6%PRS 33.2%
-
CSI 1.7rCSI 38.5%PRS 62.3%
-
CSI 1.7rCSI 2.5%PRS 16.2%
-
CSI 1.7rCSI 8.8%PRS 19.9%
-
CSI 1.7rCSI 3.1%PRS 15.7%
-
CSI 1.7rCSI 18.6%PRS 18.7%
-
CSI 1.7rCSI 14.1%PRS 10.7%
-
CSI 1.7rCSI 6.8%PRS 16.9%
-
CSI 1.8rCSI 2.3%PRS 10.8%
-
CSI 1.9rCSI 8.4%PRS 39.1%
-
CSI 1.9rCSI 8.5%PRS 48.0%
-
CSI 1.9rCSI 15.1%PRS 42.5%
-
CSI 1.9rCSI 12.2%PRS 34.0%
-
CSI 1.9rCSI 11.9%PRS 42.8%
-
CSI 2.0rCSI 10.1%PRS 20.3%
-
CSI 2.0rCSI 3.5%PRS 13.6%
-
CSI 2.0rCSI 7.1%PRS 18.6%
-
CSI 2.0rCSI 40.1%PRS 79.5%
-
CSI 2.0rCSI 35.0%PRS 41.1%
-
CSI 2.1rCSI 1.8%PRS 16.7%
-
CSI 2.1rCSI 5.0%PRS 22.9%
-
CSI 2.2rCSI 12.4%PRS 15.9%
-
CSI 2.2rCSI 34.8%PRS 74.9%
-
CSI 2.2rCSI 2.1%PRS 21.5%
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CSI 2.2rCSI 3.6%PRS 7.9%
-
CSI 2.2rCSI 9.4%PRS 27.1%
-
CSI 2.3rCSI 6.4%PRS 16.0%
-
CSI 2.3rCSI 5.9%PRS 9.6%
-
CSI 2.3rCSI 4.4%PRS 22.4%
-
CSI 2.4rCSI 1.4%PRS 14.2%
-
CSI 2.5rCSI 63.0%PRS 33.8%
-
CSI 2.5rCSI 4.5%PRS 8.6%
-
CSI 2.7rCSI 6.4%PRS 16.3%
-
CSI 2.7rCSI 6.7%PRS 7.9%
-
CSI 2.7rCSI 3.7%PRS 21.4%
-
CSI 2.7rCSI 8.8%PRS 15.1%
-
CSI 2.8rCSI 15.0%PRS 25.8%
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CSI 2.8rCSI 14.6%PRS 18.9%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3510106812
Symbol: NPC2_HUMAN
Name: Epididymal secretory protein E1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8418812
Title: Region-specific variation of gene expression in the human epididymis as revealed by in situ hybridization with tissue-specific cDNAs.
PubMed ID: 8418812
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 12508121
Title: The DNA sequence and analysis of human chromosome 14.
PubMed ID: 12508121
DOI: 10.1038/nature01348
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17018531
Title: NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols.
PubMed ID: 17018531
PubMed ID: 11125141
Title: Identification of HE1 as the second gene of Niemann-Pick C disease.
PubMed ID: 11125141
PubMed ID: 15110773
Title: In vivo interaction between the human dehydrodolichyl diphosphate synthase and the Niemann-Pick C2 protein revealed by a yeast two-hybrid system.
PubMed ID: 15110773
PubMed ID: 16548883
Title: Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection.
PubMed ID: 16548883
PubMed ID: 18823126
Title: Regulation of sterol transport between membranes and NPC2.
PubMed ID: 18823126
DOI: 10.1021/bi801328u
PubMed ID: 18772377
Title: NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes.
PubMed ID: 18772377
PubMed ID: 19664597
Title: Identification of NPC2 protein as interaction molecule with C2 domain of human Nedd4L.
PubMed ID: 19664597
PubMed ID: 19723497
Title: Nogo-B receptor stabilizes Niemann-Pick type C2 protein and regulates intracellular cholesterol trafficking.
PubMed ID: 19723497
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21315718
Title: NPC2 regulates biliary cholesterol secretion via stimulation of ABCG5/G8-mediated cholesterol transport.
PubMed ID: 21315718
PubMed ID: 22095670
Title: Novel function of Niemann-Pick C1-like 1 as a negative regulator of Niemann-Pick C2 protein.
PubMed ID: 22095670
DOI: 10.1002/hep.24772
PubMed ID: 18832164
Title: NPC1/NPC2 function as a tag team duo to mobilize cholesterol.
PubMed ID: 18832164
PubMed ID: 19232397
Title: Niemann-Pick C2 (NPC2) and intracellular cholesterol trafficking.
PubMed ID: 19232397
PubMed ID: 20674853
PubMed ID: 21412152
Title: Function of the Niemann-Pick type C proteins and their bypass by cyclodextrin.
PubMed ID: 21412152
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27238017
Title: Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection.
PubMed ID: 27238017
PubMed ID: 29580834
Title: Niemann-Pick C2 protein regulates sterol transport between plasma membrane and late endosomes in human fibroblasts.
PubMed ID: 29580834
PubMed ID: 27551080
Title: Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2.
PubMed ID: 27551080
PubMed ID: 11567215
Title: Niemann-Pick disease type C: spectrum of HE1 mutations and genotype/phenotype correlations in the NPC2 group.
PubMed ID: 11567215
DOI: 10.1086/324068
PubMed ID: 12447927
Title: Frontal lobe atrophy due to a mutation in the cholesterol binding protein HE1/NPC2.
PubMed ID: 12447927
DOI: 10.1002/ana.10366
PubMed ID: 12955717
Title: Identification of 58 novel mutations in Niemann-Pick disease type C: correlation with biochemical phenotype and importance of PTC1-like domains in NPC1.
PubMed ID: 12955717
DOI: 10.1002/humu.10255
PubMed ID: 15937921
Title: Niemann-Pick type C disease: subcellular location and functional characterization of NPC2 proteins with naturally occurring missense mutations.
PubMed ID: 15937921
DOI: 10.1002/humu.20173
PubMed ID: 16126423
Title: Niemann-Pick C disease: use of denaturing high performance liquid chromatography for the detection of NPC1 and NPC2 genetic variations and impact on management of patients and families.
PubMed ID: 16126423
Sequence Information:
- Length: 151
- Mass: 16570
- Checksum: B141B611805DC910
- Sequence:
MRFLAATFLL LALSTAAQAE PVQFKDCGSV DGVIKEVNVS PCPTQPCQLS KGQSYSVNVT FTSNIQSKSS KAVVHGILMG VPVPFPIPEP DGCKSGINCP IQKDKTYSYL NKLPVKSEYP SIKLVVEWQL QDDKNQSLFC WEIPVQIVSH L