DRAP1 | ENSG00000175550 | NCBI 10589

Details for: DRAP1

Gene ID: 10589

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: DRAP1

Ensembl ID: ENSG00000175550

Description: DR1 associated protein 1

Cell Significance Landscape

Display Count:

Associated with

Developmental biology
(R-HSA-1266738)
Signaling by activin
(R-HSA-1502540)
Signaling by nodal
(R-HSA-1181150)
Signaling by tgfb family members
(R-HSA-9006936)
Signal transduction
(R-HSA-162582)
Core promoter sequence-specific dna binding
(GO:0001046)
Dna binding
(GO:0003677)
Identical protein binding
(GO:0042802)
Negative cofactor 2 complex
(GO:0017054)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Rna polymerase ii general transcription initiation factor activity
(GO:0016251)
Rna polymerase ii general transcription initiation factor binding
(GO:0001091)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Tbp-class protein binding
(GO:0017025)
Transcription by rna polymerase ii
(GO:0006366)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

CD14-low, CD16-positive monocyte CL0002396

CSI 92.27

rCSI 71.09%

PRS 7.8
megakaryocyte-erythroid progenitor cell CL0000050

CSI 78.39

rCSI 70.79%

PRS 7.63
hematopoietic stem cell CL0000037

CSI 71.17

rCSI 47.3%

PRS 10.3
early lymphoid progenitor CL0000936

CSI 60.2

rCSI 52.87%

PRS 9.69
common myeloid progenitor CL0000049

CSI 59.49

rCSI 48.11%

PRS 8.52
keratinocyte CL0000312

CSI 52.17

rCSI 43.73%

PRS 10.32
common dendritic progenitor CL0001029

CSI 51.66

rCSI 64.83%

PRS 11.02
peripheral nervous system neuron CL2000032

CSI 46.74

rCSI 63.68%

PRS 7.73
granulocyte monocyte progenitor cell CL0000557

CSI 43.7

rCSI 37.84%

PRS 9.64
plasmablast CL0000980

CSI 42.07

rCSI 33.1%

PRS 10.29
fallopian tube secretory epithelial cell CL4030006

CSI 41.58

rCSI 40.03%

PRS 8.95
fraction A pre-pro B cell CL0002045

CSI 38.48

rCSI 44.05%

PRS 17.85
common lymphoid progenitor CL0000051

CSI 34.41

rCSI 45.98%

PRS 16.52
promyelocyte CL0000836

CSI 31.03

rCSI 44.75%

PRS 12.07
pancreatic A cell CL0000171

CSI 29.68

rCSI 31.09%

PRS 9.19
double negative thymocyte CL0002489

CSI 29.46

rCSI 20.48%

PRS 10.11
CD1c-positive myeloid dendritic cell CL0002399

CSI 29.28

rCSI 35.36%

PRS 10.15
extravillous trophoblast CL0008036

CSI 27.55

rCSI 34.08%

PRS 7.57
pancreatic D cell CL0000173

CSI 23.94

rCSI 23.55%

PRS 9.36
enteric smooth muscle cell CL0002504

CSI 23.08

rCSI 32.94%

PRS 9.77
non-classical monocyte CL0000875

CSI 22.57

rCSI 36.17%

PRS 27.74
Hofbauer cell CL3000001

CSI 22.07

rCSI 41.66%

PRS 10.72
myeloid leukocyte CL0000766

CSI 22.02

rCSI 20.31%

PRS 8.78
mammary gland epithelial cell CL0002327

CSI 21.85

rCSI 76.65%

PRS 15.71
pancreatic ductal cell CL0002079

CSI 21.53

rCSI 41.87%

PRS 8.8
double-positive, alpha-beta thymocyte CL0000809

CSI 20.93

rCSI 21.33%

PRS 12.33
retinal cone cell CL0000573

CSI 18.9

rCSI 30.42%

PRS 6.59
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 18.46

rCSI 13.84%

PRS 25.4
microcirculation associated smooth muscle cell CL0008035

CSI 18.42

rCSI 53.33%

PRS 9.8
basal cell of prostate epithelium CL0002341

CSI 17.91

rCSI 51.82%

PRS 19.38
elicited macrophage CL0000861

CSI 17.57

rCSI 16.13%

PRS 9.85
CD14-positive, CD16-positive monocyte CL0002397

CSI 17.42

rCSI 22.83%

PRS 12.09
promonocyte CL0000559

CSI 17.07

rCSI 29.24%

PRS 11.58
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI 16.18

rCSI 27.68%

PRS 18.09
forebrain radial glial cell CL0013000

CSI 16.02

rCSI 51.4%

PRS 12.85
CD16-positive, CD56-dim natural killer cell, human CL0000939

CSI 14.05

rCSI 9.36%

PRS 23.55
large pre-B-II cell CL0000957

CSI 14.03

rCSI 40.05%

PRS 15.26
conventional dendritic cell CL0000990

CSI 13.73

rCSI 11.46%

PRS 26.82
thymocyte CL0000893

CSI 12.96

rCSI 46.05%

PRS 27.61
duct epithelial cell CL0000068

CSI 12

rCSI 17.55%

PRS 9.15
primitive red blood cell CL0002355

CSI 11.71

rCSI 63.18%

PRS 16.44
hepatocyte CL0000182

CSI 11.02

rCSI 19.72%

PRS 8.13
Langerhans cell CL0000453

CSI 10.79

rCSI 16.48%

PRS 15.13
type B pancreatic cell CL0000169

CSI 10.36

rCSI 22.93%

PRS 8
pancreatic stellate cell CL0002410

CSI 10.28

rCSI 59.79%

PRS 13.05
myeloid lineage restricted progenitor cell CL0000839

CSI 10.16

rCSI 52.44%

PRS 17.3
epithelial cell of lung CL0000082

CSI 10.08

rCSI 8.36%

PRS 8.18
retina horizontal cell CL0000745

CSI 9.96

rCSI 15.18%

PRS 8.08
transitional stage B cell CL0000818

CSI 9.8

rCSI 32.08%

PRS 25.71
pancreatic PP cell CL0002275

CSI 9.73

rCSI 38.72%

PRS 15.25
myeloid dendritic cell, human CL0001057

CSI 9.65

rCSI 54.31%

PRS 27.7
intraepithelial lymphocyte CL0002496

CSI 9.36

rCSI 25.48%

PRS 37.66
alveolar macrophage CL0000583

CSI 9.15

rCSI 15.06%

PRS 10.09
amacrine cell CL0000561

CSI 9.06

rCSI 26.25%

PRS 6.92
progenitor cell CL0011026

CSI 9

rCSI 19.14%

PRS 15.76
plasmacytoid dendritic cell, human CL0001058

CSI 8.93

rCSI 6.24%

PRS 9.1
eosinophil CL0000771

CSI 8.51

rCSI 55.84%

PRS 22.76
mesenchymal stem cell CL0000134

CSI 8.42

rCSI 92.15%

PRS 15.8
luminal epithelial cell of mammary gland CL0002326

CSI 8.29

rCSI 15.06%

PRS 13.2
stem cell CL0000034

CSI 8.12

rCSI 7.83%

PRS 5.6
unswitched memory B cell CL0000970

CSI 8.07

rCSI 6.79%

PRS 14.21
CD4-positive helper T cell CL0000492

CSI 7.9

rCSI 5.98%

PRS 12
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 7.82

rCSI 5.49%

PRS 23.99
retinal ganglion cell CL0000740

CSI 7.73

rCSI 17.09%

PRS 6.16
hematopoietic precursor cell CL0008001

CSI 7.55

rCSI 7.76%

PRS 14.11
radial glial cell CL0000681

CSI 7.34

rCSI 10.2%

PRS 8.9
CD4-positive, alpha-beta thymocyte CL0000810

CSI 7.07

rCSI 5.66%

PRS 15.78
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 6.73

rCSI 40.69%

PRS 19.73
cerebral cortex GABAergic interneuron CL0010011

CSI 6.63

rCSI 19.56%

PRS 10.76
classical monocyte CL0000860

CSI 6.55

rCSI 9.71%

PRS 63.8
group 3 innate lymphoid cell CL0001071

CSI 6.5

rCSI 4.88%

PRS 8.92
enteroendocrine cell CL0000164

CSI 6.37

rCSI 8.71%

PRS 9.53
Cajal-Retzius cell CL0000695

CSI 6.35

rCSI 49.78%

PRS 19.48
neural crest cell CL0011012

CSI 6.33

rCSI 5%

PRS 5.94
mature NK T cell CL0000814

CSI 6.32

rCSI 8.09%

PRS 37.35
naive T cell CL0000898

CSI 6.26

rCSI 4.36%

PRS 12.4
basophil mast progenitor cell CL0002028

CSI 6.05

rCSI 32.28%

PRS 31.97
naive thymus-derived CD4-positive, alpha-beta T cell CL0000895

CSI 5.99

rCSI 7.53%

PRS 41.04
bronchus fibroblast of lung CL2000093

CSI 5.9

rCSI 4.8%

PRS 9.17
memory T cell CL0000813

CSI 5.88

rCSI 11.33%

PRS 19.61
group 2 innate lymphoid cell CL0001069

CSI 5.88

rCSI 31.79%

PRS 29.95
T-helper 1 cell CL0000545

CSI 5.78

rCSI 10.44%

PRS 24.55
interstitial cell of Cajal CL0002088

CSI 5.63

rCSI 7.17%

PRS 10.04
hematopoietic multipotent progenitor cell CL0000837

CSI 5.62

rCSI 13.52%

PRS 13.76
stromal cell of ovary CL0002132

CSI 5.55

rCSI 15.26%

PRS 14.38
myofibroblast cell CL0000186

CSI 5.54

rCSI 7.68%

PRS 12.44
lymphoid lineage restricted progenitor cell CL0000838

CSI 5.39

rCSI 20.97%

PRS 14.27
CD4-positive, alpha-beta memory T cell CL0000897

CSI 5.25

rCSI 3.77%

PRS 11.76
fibroblast of lung CL0002553

CSI 5.21

rCSI 4.84%

PRS 8.68
pro-B cell CL0000826

CSI 5.16

rCSI 4.28%

PRS 8.63
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 5.1

rCSI 7.01%

PRS 18.2
multi-ciliated epithelial cell CL0005012

CSI 4.94

rCSI 4.93%

PRS 7.4
secretory cell CL0000151

CSI 4.9

rCSI 5.11%

PRS 8.86
dendritic cell CL0000451

CSI 4.85

rCSI 5.97%

PRS 28.6
kidney epithelial cell CL0002518

CSI 4.81

rCSI 9.19%

PRS 20.81
mesodermal cell CL0000222

CSI 4.81

rCSI 5.77%

PRS 8.56
CD8-positive, alpha-beta memory T cell CL0000909

CSI 4.76

rCSI 4.97%

PRS 27.07
plasma cell CL0000786

CSI 4.73

rCSI 6.2%

PRS 41.1
mononuclear phagocyte CL0000113

CSI 4.67

rCSI 10.27%

PRS 9.5
B cell CL0000236

CSI 4.66

rCSI 6.23%

PRS 40.27

lung neuroendocrine cell CL1000223

CSI -18.4

rCSI -27.3%

PRS 9.9%
smooth muscle cell of prostate CL1000487

CSI -5.9

rCSI -34.9%

PRS 40.5%
tracheobronchial smooth muscle cell CL0019019

CSI -3.2

rCSI -5.6%

PRS 11.4%
ciliated columnar cell of tracheobronchial tree CL0002145

CSI -1.8

rCSI -4.0%

PRS 9.1%
near-projecting glutamatergic cortical neuron CL4023012

CSI -0.7

rCSI -2.7%

PRS 5.2%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI -0.5

rCSI -3.1%

PRS 5.4%
pulmonary artery endothelial cell CL1001568

CSI -0.5

rCSI -0.7%

PRS 13.3%
peptic cell CL0000155

CSI -0.5

rCSI -4.9%

PRS 26.6%
intrahepatic cholangiocyte CL0002538

CSI -0.4

rCSI -0.9%

PRS 16.1%
immature alpha-beta T cell CL0000790

CSI -0.1

rCSI -1.3%

PRS 76.4%
acinar cell of salivary gland CL0002623

CSI 0.0

rCSI 0.4%

PRS 14.7%
B-2 B cell CL0000822

CSI 0.0

rCSI 0.5%

PRS 48.0%
paneth cell of colon CL0009009

CSI 0.1

rCSI 0.6%

PRS 25.5%
mesenchymal lymphangioblast CL0005021

CSI 0.1

rCSI 2.9%

PRS 43.2%
osteoblast CL0000062

CSI 0.1

rCSI 3.4%

PRS 62.9%
L6b glutamatergic cortical neuron CL4023038

CSI 0.2

rCSI 0.5%

PRS 5.5%
lamp5 GABAergic cortical interneuron CL4023011

CSI 0.2

rCSI 0.3%

PRS 5.1%
Merkel cell CL0000242

CSI 0.2

rCSI 4.5%

PRS 55.9%
cytotoxic T cell CL0000910

CSI 0.2

rCSI 1.2%

PRS 13.0%
follicular B cell CL0000843

CSI 0.2

rCSI 0.8%

PRS 37.1%
decidual natural killer cell, human CL0002343

CSI 0.3

rCSI 2.9%

PRS 59.7%
chondrocyte CL0000138

CSI 0.3

rCSI 0.5%

PRS 7.5%
vasa recta descending limb cell CL1001285

CSI 0.3

rCSI 2.5%

PRS 37.2%
IgM plasma cell CL0000986

CSI 0.3

rCSI 1.5%

PRS 42.5%
sst GABAergic cortical interneuron CL4023017

CSI 0.3

rCSI 0.4%

PRS 5.4%
blood vessel smooth muscle cell CL0019018

CSI 0.3

rCSI 2.8%

PRS 9.1%
ciliated cell CL0000064

CSI 0.4

rCSI 0.6%

PRS 8.8%
mature B cell CL0000785

CSI 0.4

rCSI 0.3%

PRS 10.7%
transit amplifying cell CL0009010

CSI 0.4

rCSI 0.6%

PRS 14.1%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 0.4

rCSI 1.3%

PRS 5.9%
antibody secreting cell CL0000946

CSI 0.4

rCSI 1.9%

PRS 37.0%
ionocyte CL0005006

CSI 0.4

rCSI 0.5%

PRS 7.9%
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 0.4

rCSI 0.9%

PRS 14.6%
follicular dendritic cell CL0000442

CSI 0.5

rCSI 7.2%

PRS 48.3%
podocyte CL0000653

CSI 0.5

rCSI 2.1%

PRS 8.6%
intestinal crypt stem cell of colon CL0009043

CSI 0.5

rCSI 3.6%

PRS 16.0%
double negative T regulatory cell CL0011024

CSI 0.5

rCSI 9.3%

PRS 54.6%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 0.5

rCSI 0.9%

PRS 5.1%
epithelial cell of proximal tubule CL0002306

CSI 0.5

rCSI 1.3%

PRS 8.8%
basal cell of epithelium of trachea CL1000348

CSI 0.5

rCSI 3.8%

PRS 27.4%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 0.6

rCSI 1.4%

PRS 4.9%
prostate gland microvascular endothelial cell CL2000059

CSI 0.6

rCSI 13.5%

PRS 31.2%
colon goblet cell CL0009039

CSI 0.6

rCSI 1.4%

PRS 13.0%
squamous epithelial cell CL0000076

CSI 0.6

rCSI 1.4%

PRS 11.3%
glandular epithelial cell CL0000150

CSI 0.6

rCSI 1.6%

PRS 17.0%
neural progenitor cell CL0011020

CSI 0.6

rCSI 2.8%

PRS 8.6%
respiratory epithelial cell CL0002368

CSI 0.7

rCSI 4.1%

PRS 28.5%
retinal bipolar neuron CL0000748

CSI 0.7

rCSI 1.3%

PRS 6.3%
basal-myoepithelial cell of mammary gland CL0002324

CSI 0.7

rCSI 1.3%

PRS 19.1%
cerebellar granule cell CL0001031

CSI 0.7

rCSI 1.1%

PRS 8.2%
type L enteroendocrine cell CL0002279

CSI 0.7

rCSI 1.4%

PRS 17.1%
helper T cell CL0000912

CSI 0.8

rCSI 1.1%

PRS 12.4%
sncg GABAergic cortical interneuron CL4023015

CSI 0.8

rCSI 1.2%

PRS 5.6%
bronchial goblet cell CL1000312

CSI 0.8

rCSI 3.1%

PRS 19.2%
intestinal crypt stem cell of small intestine CL0009017

CSI 0.8

rCSI 2.2%

PRS 11.2%
ventricular cardiac muscle cell CL2000046

CSI 0.8

rCSI 2.8%

PRS 35.9%
natural T-regulatory cell CL0000903

CSI 0.8

rCSI 1.6%

PRS 24.5%
BEST4+ enteroycte CL4030026

CSI 0.9

rCSI 1.1%

PRS 9.2%
kidney connecting tubule epithelial cell CL1000768

CSI 0.9

rCSI 2.2%

PRS 6.7%
erythroblast CL0000765

CSI 0.9

rCSI 2.3%

PRS 14.6%
cerebral cortex pyramidal neuron CL4023111

CSI 0.9

rCSI 5.6%

PRS 27.1%
corneal epithelial cell CL0000575

CSI 0.9

rCSI 2.7%

PRS 16.0%
pulmonary alveolar type 1 cell CL0002062

CSI 0.9

rCSI 5.4%

PRS 12.0%
neuroendocrine cell CL0000165

CSI 1.0

rCSI 3.7%

PRS 18.3%
IgG plasma cell CL0000985

CSI 1.0

rCSI 1.1%

PRS 15.0%
small pre-B-II cell CL0000954

CSI 1.0

rCSI 0.9%

PRS 18.5%
retinal blood vessel endothelial cell CL0002585

CSI 1.0

rCSI 1.6%

PRS 9.4%
foveolar cell of stomach CL0002179

CSI 1.0

rCSI 2.1%

PRS 14.0%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 1.0

rCSI 2.6%

PRS 8.1%
alveolar type 1 fibroblast cell CL4028004

CSI 1.0

rCSI 1.1%

PRS 10.0%
activated CD4-positive, alpha-beta T cell, human CL0001043

CSI 1.0

rCSI 2.5%

PRS 50.7%
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 1.0

rCSI 1.3%

PRS 12.3%
platelet CL0000233

CSI 1.1

rCSI 4.4%

PRS 21.0%
stromal cell CL0000499

CSI 1.1

rCSI 3.0%

PRS 12.5%
B-1 B cell CL0000819

CSI 1.1

rCSI 28.5%

PRS 45.1%
paneth cell of epithelium of small intestine CL1000343

CSI 1.1

rCSI 3.2%

PRS 13.4%
basophil CL0000767

CSI 1.1

rCSI 2.4%

PRS 18.4%
intestinal tuft cell CL0019032

CSI 1.2

rCSI 1.8%

PRS 10.0%
tendon cell CL0000388

CSI 1.2

rCSI 3.0%

PRS 25.2%
myoepithelial cell CL0000185

CSI 1.2

rCSI 2.9%

PRS 10.8%
club cell CL0000158

CSI 1.2

rCSI 1.7%

PRS 10.1%
metallothionein-positive alveolar macrophage CL4033042

CSI 1.2

rCSI 12.8%

PRS 37.1%
endocrine cell CL0000163

CSI 1.2

rCSI 6.0%

PRS 37.2%
fibroblast of breast CL4006000

CSI 1.2

rCSI 5.1%

PRS 23.1%
enteroendocrine cell of colon CL0009042

CSI 1.2

rCSI 5.7%

PRS 23.5%
basal cell of epidermis CL0002187

CSI 1.2

rCSI 2.2%

PRS 10.0%
germinal center B cell CL0000844

CSI 1.2

rCSI 3.7%

PRS 22.3%
vascular associated smooth muscle cell CL0000359

CSI 1.3

rCSI 4.1%

PRS 10.6%
vein endothelial cell of respiratory system CL4033008

CSI 1.3

rCSI 8.8%

PRS 17.0%
myeloid dendritic cell CL0000782

CSI 1.3

rCSI 1.9%

PRS 12.7%
pancreatic epsilon cell CL0005019

CSI 1.3

rCSI 6.2%

PRS 21.2%
lung resident memory CD8-positive, alpha-beta T cell CL4033039

CSI 1.3

rCSI 3.4%

PRS 25.6%
macroglial cell CL0000126

CSI 1.3

rCSI 3.4%

PRS 13.4%
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 1.3

rCSI 6.7%

PRS 11.3%
lung pericyte CL0009089

CSI 1.4

rCSI 3.6%

PRS 10.3%
respiratory suprabasal cell CL4033048

CSI 1.4

rCSI 1.8%

PRS 10.0%
T follicular helper cell CL0002038

CSI 1.4

rCSI 1.1%

PRS 14.1%
hepatic stellate cell CL0000632

CSI 1.5

rCSI 5.5%

PRS 7.4%
lung endothelial cell CL1001567

CSI 1.5

rCSI 3.4%

PRS 21.3%
placental villous trophoblast CL2000060

CSI 1.5

rCSI 2.3%

PRS 8.1%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [DRAP1](/details-gene/10589) (DR1 Associated Protein 1) is a protein-coding gene that functions as a corepressor in the regulation of gene transcription. As a component of the Negative Cofactor 2 (NC2) complex, it plays a critical role in modulating the activity of RNA polymerase II by binding to the TATA-binding protein (TBP) ([Link](https://pubmed.ncbi.nlm.nih.gov/8670811/)). **Overall**, its expression profile suggests a fundamental role in developmental processes, particularly hematopoiesis, as it is a highly significant gene in various progenitor cells including [CD14-low, CD16-positive monocyte](/details-cell/CL0002396), [megakaryocyte-erythroid progenitor cell](/details-cell/CL0000050), and [hematopoietic stem cell](/details-cell/CL0000037). Its function is linked to OMIM entry [602289](https://omim.org/entry/602289). ## Cellular Roles and Expression Landscape The expression pattern of [DRAP1](/details-gene/10589) strongly indicates its importance in the regulation of cell fate and differentiation within the hematopoietic system. It demonstrates high significance scores across a spectrum of progenitor cells, including [hematopoietic stem cell](/details-cell/CL0000037), [megakaryocyte-erythroid progenitor cell](/details-cell/CL0000050), [early lymphoid progenitor](/details-cell/CL0000936), and [common myeloid progenitor](/details-cell/CL0000049). This suggests that [DRAP1](/details-gene/10589) is a key regulator involved in maintaining the undifferentiated state or guiding early lineage commitment in blood cell development. Beyond progenitor cells, [DRAP1](/details-gene/10589) is also a top marker in more mature but highly active cell types such as the [CD14-low, CD16-positive monocyte](/details-cell/CL0002396). Its significance extends to non-hematopoietic cells like [keratinocyte](/details-cell/CL0000312) and [peripheral nervous system neuron](/details-cell/CL2000032), implying a broader role in transcriptional regulation in diverse tissues. Conversely, its low significance in terminally differentiated cells such as [smooth muscle cell of prostate](/details-cell/CL1000487) and [ciliated columnar cell of tracheobronchial tree](/details-cell/CL0002145) suggests its function is less critical for maintaining the specialized transcriptional programs of these cell types. ## Pathways and Molecular Function Functionally, [DRAP1](/details-gene/10589) is an integral component of the transcriptional machinery. It is annotated with molecular functions including [core promoter sequence-specific dna binding](/details-go/GO:0001046) and [Tbp-class protein binding](/details-go/GO:0017025). As part of the [Negative cofactor 2 complex](/details-go/GO:0017054), it participates in the [negative regulation of transcription by rna polymerase ii](/details-go/GO:0000122). The mechanism involves the NC2 complex, which includes [DRAP1](/details-gene/10589), binding to TBP and preventing the assembly of the preinitiation complex at promoters, thereby repressing transcription ([Link](https://pubmed.ncbi.nlm.nih.gov/8608938/); [Link](https://pubmed.ncbi.nlm.nih.gov/11461703/)). The involvement of [DRAP1](/details-gene/10589) in high-level biological processes such as [Developmental biology](/details-pathway/R-HSA-1266738) and [Signaling by tgfb family members](/details-pathway/R-HSA-9006936) is consistent with its expression pattern. TGF-beta and related signaling pathways are crucial for directing the differentiation of stem and progenitor cells, a context where the precise repression of inappropriate gene programs by [DRAP1](/details-gene/10589) would be essential. ## Research Directions The widespread and high-level expression of [DRAP1](/details-gene/10589) in hematopoietic progenitors, coupled with its role as a transcriptional repressor, opens up several avenues for future research. **Proposed Hypotheses:** 1. Given its high significance in multiple hematopoietic stem and progenitor populations, [DRAP1](/details-gene/10589) functions as a crucial "gatekeeper" of lineage commitment. It may act by repressing lineage-specific transcription factors, thereby maintaining multipotency until specific developmental cues trigger its displacement from target promoters. 2. The high significance in [CD14-low, CD16-positive monocyte](/details-cell/CL0002396), a non-classical monocyte subset, suggests that [DRAP1](/details-gene/10589) is essential for establishing or maintaining the unique transcriptional identity of this cell type, potentially by suppressing the inflammatory gene programs characteristic of classical monocytes. **Key Experimental Approach:** To test the hypothesis that [DRAP1](/details-gene/10589) is a gatekeeper of hematopoietic lineage commitment, one could perform a CRISPR-Cas9-mediated knockdown or knockout of [DRAP1](/details-gene/10589) in primary human CD34+ hematopoietic stem and progenitor cells. These modified cells could then be cultured under conditions that promote differentiation towards myeloid and lymphoid lineages. A combination of single-cell RNA sequencing (scRNA-seq) and ATAC-seq would reveal if the loss of [DRAP1](/details-gene/10589) leads to premature or aberrant expression of lineage-affiliated genes and changes in chromatin accessibility at key developmental loci, thus providing mechanistic insight into its gatekeeper function. **Therapeutic Potential:** As an intracellular nuclear protein that acts as a core component of the general transcription machinery, [DRAP1](/details-gene/10589) presents a challenging therapeutic target. Its essential role in stem and progenitor cell biology suggests that systemic inhibition could lead to severe toxicity, particularly hematopoietic suppression. Therefore, direct targeting of [DRAP1](/details-gene/10589) is likely not a viable strategy. However, in pathologies characterized by arrested differentiation, such as certain leukemias, understanding the downstream pathways regulated by [DRAP1](/details-gene/10589) could uncover more suitable, context-specific therapeutic targets.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Dr1-associated corepressor

Genular Protein ID: 361570448

Symbol: NC2A_HUMAN

Name: Dr1-associated corepressor

UniProtKB Accession Codes:

Q14919 Q13448

Database IDs:

Citations:

PubMed ID: 8670811

Title: A mechanism for repression of class II gene transcription through specific binding of NC2 to TBP-promoter complexes via heterodimeric histone fold domains.

PubMed ID: 8670811

DOI: 10.1002/j.1460-2075.1996.tb00673.x

PubMed ID: 8608938

Title: Requirement of a corepressor for Dr1-mediated repression of transcription.

PubMed ID: 8608938

DOI: 10.1101/gad.10.8.1033

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15509807

Title: NC2alpha interacts with BTAF1 and stimulates its ATP-dependent association with TATA-binding protein.

PubMed ID: 15509807

DOI: 10.1128/mcb.24.22.10072-10082.2004

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 11461703

Title: Crystal structure of negative cofactor 2 recognizing the TBP-DNA transcription complex.

PubMed ID: 11461703

DOI: 10.1016/s0092-8674(01)00417-2

Sequence Information:

Length: 205
Mass: 22350
Checksum: 6154C43C6B8DC877
Sequence:

MPSKKKKYNA RFPPARIKKI MQTDEEIGKV AAAVPVIISR ALELFLESLL KKACQVTQSR 
NAKTMTTSHL KQCIELEQQF DFLKDLVASV PDMQGDGEDN HMDGDKGARR GRKPGSGGRK 
NGGMGTKSKD KKLSGTDSEQ EDESEDTDTD GEEETSQPPP QASHPSAHFQ SPPTPFLPFA 
STLPLPPAPP GPSAPDEEDE EDYDS

Details for: DRAP1

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

A mechanism for repression of class II gene transcription through specific binding of NC2 to TBP-promoter complexes via heterodimeric histone fold domains. PubMed ID: 8670811

Requirement of a corepressor for Dr1-mediated repression of transcription. PubMed ID: 8608938

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

NC2alpha interacts with BTAF1 and stimulates its ATP-dependent association with TATA-binding protein. PubMed ID: 15509807

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378