Details for: USP53
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 39.71rCSI 56.98%PRS 59.68
-
CSI 29.97rCSI 47.66%PRS 62.85
-
CSI 29.65rCSI 71.28%PRS 75.96
-
CSI 27.7rCSI 35.56%PRS 61.53
-
CSI 23.22rCSI 25.43%PRS 73.43
-
CSI 17.68rCSI 42.22%PRS 77
-
CSI 16.8rCSI 55.67%PRS 75.18
-
CSI 15.57rCSI 50.68%PRS 69.32
-
CSI 14.43rCSI 13.43%PRS 70.94
-
CSI 13.31rCSI 20.34%PRS 70.9
-
CSI 13.19rCSI 69.35%PRS 73.6
-
CSI 11.95rCSI 9.29%PRS 86.38
-
CSI 11.05rCSI 11.54%PRS 87.75
-
CSI 10.75rCSI 14.63%PRS 80.46
-
CSI 10.48rCSI 18.13%PRS 60.62
-
CSI 10.04rCSI 52.73%PRS 78.03
-
CSI 9.39rCSI 24.72%PRS 85.51
-
CSI 8.72rCSI 22.12%PRS 59.81
-
CSI 8.51rCSI 8.19%PRS 69.99
-
CSI 8.37rCSI 8.74%PRS 70.17
-
CSI 8.25rCSI 18.82%PRS 61.59
-
CSI 7.85rCSI 8.22%PRS 67.19
-
CSI 7.76rCSI 22.19%PRS 79.67
-
CSI 7.41rCSI 9.91%PRS 78.41
-
CSI 7.38rCSI 5.83%PRS 57.4
-
CSI 6.98rCSI 8.19%PRS 72.42
-
CSI 6.97rCSI 5.66%PRS 70.4
-
CSI 6.89rCSI 15.71%PRS 65.4
-
CSI 6.87rCSI 15.87%PRS 58.32
-
CSI 6.77rCSI 8.42%PRS 49.47
-
CSI 6.74rCSI 37.59%PRS 76.75
-
CSI 6.68rCSI 21.5%PRS 67.85
-
CSI 6.6rCSI 9.68%PRS 81.37
-
CSI 6.39rCSI 5.61%PRS 75.62
-
CSI 6.06rCSI 8.58%PRS 66.4
-
CSI 6.01rCSI 9.6%PRS 74.38
-
CSI 6rCSI 9.71%PRS 65.89
-
CSI 5.99rCSI 23.29%PRS 72.62
-
CSI 5.88rCSI 11.94%PRS 48.45
-
CSI 5.6rCSI 17.52%PRS 55.66
-
CSI 5.58rCSI 12.22%PRS 77.04
-
CSI 5.54rCSI 9.76%PRS 66.32
-
CSI 5.26rCSI 16.45%PRS 53.17
-
CSI 5.1rCSI 7.29%PRS 72.06
-
CSI 5.08rCSI 16.26%PRS 67.3
-
CSI 5.08rCSI 22.57%PRS 70.48
-
CSI 5.06rCSI 13.18%PRS 70.55
-
CSI 5.01rCSI 5.81%PRS 76.36
-
CSI 4.91rCSI 18.39%PRS 62.16
-
CSI 4.89rCSI 7.51%PRS 62.75
-
CSI 4.56rCSI 21.35%PRS 84.1
-
CSI 4.56rCSI 3.93%PRS 73.78
-
CSI 4.47rCSI 6.41%PRS 72.6
-
CSI 4.46rCSI 11.78%PRS 78.69
-
CSI 4.31rCSI 8.08%PRS 57.93
-
CSI 4.18rCSI 5.36%PRS 74.48
-
CSI 4.09rCSI 11.63%PRS 67.31
-
CSI 3.97rCSI 3.29%PRS 72.71
-
CSI 3.95rCSI 7.68%PRS 73.65
-
CSI 3.89rCSI 3.26%PRS 73.58
-
CSI 3.84rCSI 4.12%PRS 70.68
-
CSI 3.84rCSI 18.93%PRS 80.5
-
CSI 3.82rCSI 6.15%PRS 71.74
-
CSI 3.8rCSI 2.65%PRS 84.82
-
CSI 3.8rCSI 7.25%PRS 82.92
-
CSI 3.69rCSI 6.71%PRS 83.59
-
CSI 3.68rCSI 8.78%PRS 70.61
-
CSI 3.68rCSI 4.58%PRS 72.06
-
CSI 3.56rCSI 9.2%PRS 65.07
-
CSI 3.52rCSI 3.25%PRS 87.36
-
CSI 3.47rCSI 2.42%PRS 81.74
-
CSI 3.39rCSI 5.45%PRS 53.26
-
CSI 3.38rCSI 9.31%PRS 65.17
-
CSI 3.36rCSI 10.91%PRS 69.54
-
CSI 3.33rCSI 4.3%PRS 52.73
-
CSI 3.31rCSI 4%PRS 79.22
-
CSI 3.31rCSI 7.78%PRS 72.74
-
CSI 3.27rCSI 9.72%PRS 79.95
-
CSI 3.22rCSI 5.08%PRS 72.34
-
CSI 3.16rCSI 2.62%PRS 70.25
-
CSI 3.16rCSI 8.22%PRS 72.76
-
CSI 3.14rCSI 4.29%PRS 75.86
-
CSI 3.07rCSI 2.27%PRS 63.01
-
CSI 3.02rCSI 15.49%PRS 74.42
-
CSI 3rCSI 17.08%PRS 85.06
-
CSI 2.97rCSI 6.17%PRS 67.28
-
CSI 2.95rCSI 4.51%PRS 84.18
-
CSI 2.92rCSI 2.76%PRS 69.56
-
CSI 2.88rCSI 11.58%PRS 73.13
-
CSI 2.87rCSI 8.48%PRS 69.29
-
CSI 2.85rCSI 6.37%PRS 78.22
-
CSI 2.85rCSI 2.04%PRS 83.73
-
CSI 2.77rCSI 13.93%PRS 68.78
-
CSI 2.67rCSI 7.15%PRS 61.17
-
CSI 2.67rCSI 2.73%PRS 81.69
-
CSI 2.65rCSI 3.17%PRS 51.2
-
CSI 2.56rCSI 2.26%PRS 58.2
-
CSI 2.56rCSI 13.59%PRS 61.3
-
CSI 2.54rCSI 4.45%PRS 62.66
-
CSI 2.53rCSI 4.15%PRS 59.23
-
CSI 0.2rCSI 4.3%PRS 82.4%
-
CSI 0.3rCSI 6.0%PRS 60.4%
-
CSI 0.4rCSI 5.6%PRS 61.2%
-
CSI 0.4rCSI 8.1%PRS 62.0%
-
CSI 0.4rCSI 2.5%PRS 77.1%
-
CSI 0.4rCSI 2.9%PRS 80.7%
-
CSI 0.6rCSI 5.5%PRS 84.9%
-
CSI 0.6rCSI 1.6%PRS 70.8%
-
CSI 0.7rCSI 1.9%PRS 59.4%
-
CSI 0.7rCSI 17.2%PRS 50.5%
-
CSI 0.7rCSI 1.6%PRS 56.1%
-
CSI 0.8rCSI 18.3%PRS 51.1%
-
CSI 0.8rCSI 1.4%PRS 51.4%
-
CSI 0.8rCSI 2.9%PRS 58.0%
-
CSI 0.9rCSI 2.4%PRS 80.5%
-
CSI 0.9rCSI 5.3%PRS 52.5%
-
CSI 1.0rCSI 1.8%PRS 80.3%
-
CSI 1.0rCSI 7.2%PRS 83.7%
-
CSI 1.0rCSI 7.2%PRS 56.9%
-
CSI 1.0rCSI 3.7%PRS 49.6%
-
CSI 1.1rCSI 4.8%PRS 86.1%
-
CSI 1.1rCSI 4.4%PRS 79.3%
-
CSI 1.1rCSI 4.7%PRS 83.4%
-
CSI 1.1rCSI 4.7%PRS 59.4%
-
CSI 1.1rCSI 2.4%PRS 68.9%
-
CSI 1.1rCSI 2.6%PRS 78.0%
-
CSI 1.1rCSI 2.4%PRS 79.3%
-
CSI 1.1rCSI 2.0%PRS 77.4%
-
CSI 1.2rCSI 1.7%PRS 85.0%
-
CSI 1.2rCSI 12.8%PRS 67.5%
-
CSI 1.2rCSI 2.9%PRS 72.4%
-
CSI 1.2rCSI 1.8%PRS 65.1%
-
CSI 1.2rCSI 1.9%PRS 81.8%
-
CSI 1.3rCSI 1.8%PRS 75.1%
-
CSI 1.3rCSI 3.4%PRS 71.4%
-
CSI 1.3rCSI 7.0%PRS 80.0%
-
CSI 1.3rCSI 2.0%PRS 79.5%
-
CSI 1.3rCSI 3.9%PRS 79.5%
-
CSI 1.4rCSI 2.0%PRS 79.2%
-
CSI 1.4rCSI 2.9%PRS 85.2%
-
CSI 1.4rCSI 2.1%PRS 74.7%
-
CSI 1.4rCSI 1.3%PRS 83.7%
-
CSI 1.4rCSI 1.9%PRS 76.6%
-
CSI 1.5rCSI 12.8%PRS 66.0%
-
CSI 1.5rCSI 2.2%PRS 83.7%
-
CSI 1.5rCSI 4.2%PRS 79.9%
-
CSI 1.5rCSI 2.3%PRS 69.1%
-
CSI 1.5rCSI 2.2%PRS 63.3%
-
CSI 1.6rCSI 3.8%PRS 49.8%
-
CSI 1.6rCSI 3.9%PRS 69.0%
-
CSI 1.6rCSI 1.7%PRS 78.1%
-
CSI 1.6rCSI 4.3%PRS 76.6%
-
CSI 1.6rCSI 7.7%PRS 70.2%
-
CSI 1.6rCSI 1.7%PRS 75.8%
-
CSI 1.6rCSI 3.2%PRS 66.8%
-
CSI 1.6rCSI 2.0%PRS 81.4%
-
CSI 1.6rCSI 1.7%PRS 73.8%
-
CSI 1.7rCSI 3.1%PRS 85.0%
-
CSI 1.7rCSI 6.8%PRS 69.6%
-
CSI 1.7rCSI 42.0%PRS 65.4%
-
CSI 1.7rCSI 2.0%PRS 61.2%
-
CSI 1.7rCSI 3.1%PRS 61.6%
-
CSI 1.7rCSI 1.8%PRS 68.0%
-
CSI 1.7rCSI 10.8%PRS 61.6%
-
CSI 1.8rCSI 2.2%PRS 67.2%
-
CSI 1.8rCSI 2.8%PRS 80.3%
-
CSI 1.8rCSI 42.0%PRS 85.9%
-
CSI 1.8rCSI 7.0%PRS 69.6%
-
CSI 1.8rCSI 4.0%PRS 74.4%
-
CSI 1.9rCSI 2.5%PRS 70.0%
-
CSI 1.9rCSI 2.6%PRS 62.5%
-
CSI 1.9rCSI 1.9%PRS 63.7%
-
CSI 1.9rCSI 3.0%PRS 76.6%
-
CSI 2.0rCSI 4.8%PRS 63.3%
-
CSI 2.0rCSI 7.4%PRS 52.0%
-
CSI 2.1rCSI 3.7%PRS 50.5%
-
CSI 2.1rCSI 3.8%PRS 69.6%
-
CSI 2.1rCSI 1.6%PRS 76.0%
-
CSI 2.2rCSI 1.9%PRS 68.1%
-
CSI 2.2rCSI 1.5%PRS 83.4%
-
CSI 2.2rCSI 15.7%PRS 69.5%
-
CSI 2.2rCSI 2.7%PRS 77.4%
-
CSI 2.3rCSI 3.6%PRS 59.6%
-
CSI 2.3rCSI 2.2%PRS 62.0%
-
CSI 2.4rCSI 9.3%PRS 88.3%
-
CSI 2.4rCSI 10.1%PRS 69.7%
-
CSI 2.5rCSI 5.5%PRS 52.0%
-
CSI 2.5rCSI 4.9%PRS 59.4%
-
CSI 2.5rCSI 1.9%PRS 73.5%
-
CSI 2.5rCSI 4.5%PRS 63.3%
-
CSI 2.5rCSI 6.3%PRS 77.1%
-
CSI 2.5rCSI 11.9%PRS 68.1%
-
CSI 2.5rCSI 2.0%PRS 80.5%
-
CSI 2.5rCSI 5.8%PRS 70.8%
-
CSI 2.5rCSI 3.9%PRS 79.3%
-
CSI 2.5rCSI 4.3%PRS 89.4%
-
CSI 2.5rCSI 4.2%PRS 59.2%
-
CSI 2.5rCSI 4.5%PRS 62.7%
-
CSI 2.6rCSI 13.6%PRS 61.3%
-
CSI 2.6rCSI 2.3%PRS 58.2%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1994388794
Symbol: UBP53_HUMAN
Name: Inactive ubiquitin carboxyl-terminal hydrolase 53
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14715245
Title: Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases.
PubMed ID: 14715245
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 10718198
Title: Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 10718198
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 30250217
Title: Identification of novel loci for pediatric cholestatic liver disease defined by KIF12, PPM1F, USP53, LSR, and WDR83OS pathogenic variants.
PubMed ID: 30250217
PubMed ID: 32124521
Title: Low-GGT intrahepatic cholestasis associated with biallelic USP53 variants: Clinical, histological and ultrastructural characterization.
PubMed ID: 32124521
DOI: 10.1111/liv.14422
PubMed ID: 33083013
Title: Genomic testing in 1019 individuals from 349 Pakistani families results in high diagnostic yield and clinical utility.
PubMed ID: 33083013
PubMed ID: 33075013
Sequence Information:
- Length: 1073
- Mass: 120806
- Checksum: 2A5E8B0AB4158878
- Sequence:
MAWVKFLRKP GGNLGKVYQP GSMLSLAPTK GLLNEPGQNS CFLNSAVQVL WQLDIFRRSL RVLTGHVCQG DACIFCALKT IFAQFQHSRE KALPSDNIRH ALAESFKDEQ RFQLGLMDDA AECFENMLER IHFHIVPSRD ADMCTSKSCI THQKFAMTLY EQCVCRSCGA SSDPLPFTEF VRYISTTALC NEVERMLERH ERFKPEMFAE LLQAANTTDD YRKCPSNCGQ KIKIRRVLMN CPEIVTIGLV WDSEHSDLTE AVVRNLATHL YLPGLFYRVT DENAKNSELN LVGMICYTSQ HYCAFAFHTK SSKWVFFDDA NVKEIGTRWK DVVSKCIRCH FQPLLLFYAN PDGTAVSTED ALRQVISWSH YKSVAENMGC EKPVIHKSDN LKENGFGDQA KQRENQKFPT DNISSSNRSH SHTGVGKGPA KLSHIDQREK IKDISRECAL KAIEQKNLLS SQRKDLEKGQ RKDLGRHRDL VDEDLSHFQS GSPPAPNGFK QHGNPHLYHS QGKGSYKHDR VVPQSRASAQ IISSSKSQIL APGEKITGKV KSDNGTGYDT DSSQDSRDRG NSCDSSSKSR NRGWKPMRET LNVDSIFSES EKRQHSPRHK PNISNKPKSS KDPSFSNWPK ENPKQKGLMT IYEDEMKQEI GSRSSLESNG KGAEKNKGLV EGKVHGDNWQ MQRTESGYES SDHISNGSTN LDSPVIDGNG TVMDISGVKE TVCFSDQITT SNLNKERGDC TSLQSQHHLE GFRKELRNLE AGYKSHEFHP ESHLQIKNHL IKRSHVHEDN GKLFPSSSLQ IPKDHNAREH IHQSDEQKLE KPNECKFSEW LNIENSERTG LPFHVDNSAS GKRVNSNEPS SLWSSHLRTV GLKPETAPLI QQQNIMDQCY FENSLSTECI IRSASRSDGC QMPKLFCQNL PPPLPPKKYA ITSVPQSEKS ESTPDVKLTE VFKATSHLPK HSLSTASEPS LEVSTHMNDE RHKETFQVRE CFGNTPNCPS SSSTNDFQAN SGAIDAFCQP ELDSISTCPN ETVSLTTYFS VDSCMTDTYR LKYHQRPKLS FPESSGFCNN SLS
Genular Protein ID: 4283010807
Symbol: A0A8J9FKG6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
Sequence Information:
- Length: 800
- Mass: 90412
- Checksum: A817596569EAA868
- Sequence:
MAWVKFLRKP GGNLGKVYQP GSMLSLAPTK GLLNEPGQNS CFLNSAVQVL WQLDIFRRSL RVLTGHVCQG DACIFCALKT IFAQFQHSRE KALPSDNIRH ALAESFKDEQ RFQLGLMDDA AECFENMLER IHFHIVPSRD ADMCTSKSCI THQKFAMTLY EQCVCRSCGA SSDPLPFTEF VRYISTTALC NEVERMLERH ERFKPEMFAE LLQAANTTDD YRKCPSNCGQ KIKIRRVLMN CPEIVTIGLV WDSEHSDLTE AVVRNLATHL YLPGLFYRVT DENAKNSELN LVGMICYTSQ HYCAFAFHTK SSKWVFFDDA NVKEIGTRWK DVVSKCIRCH FQPLLLFYAN PDGTAVSTED ALRQVISWSH YKSVAENMGC EKPVIHKSDN LKENGFGDQA KQRENQKFPT DNISSSNRSH SHTGVGKGPA KLSHIDQREK IKDISRECAL KAIEQKNLLS SQRKDLEKGQ RKDLGRHRDL VDEDLSHFQS GSPPAPNGFK QHGNPHLYHS QGKGSYKHDR VVPQSRASAQ IISSSKSQIL APGEKITGKV KSDNGTGYDT DSSQDSRDRG NSCDSSSKSR NRGWKPMRET LNVDSIFSES EKRQHSPRHK PNISNKPKSS KDPSFSNWPK ENPKQKGLMT IYEDEMKQEI GSRSSLESNG KGAEKNKGLV EGKVHGDNWQ MQRTESGYES SDHISNGSTN LDSPVIDGNG TVMDISGVKE TVCFSDQITT SNLNKERGDC TSLQSQHHLE DHMYMKTMES YFLHPVYKYP RTIMQENIST SQMNRNLKNR MNANFLSGLI
Genular Protein ID: 1793056332
Symbol: Q9H9I0_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
Sequence Information:
- Length: 188
- Mass: 20829
- Checksum: 36C7DF0E33BF8C05
- Sequence:
MDQCYFENSL STECIIRSAS RSDGCQMPKL FCQNLPPPLP PKKYAITSVP QSEKSESTPG VKLTEVFKAT SHLPKHSLST ASEPSLEVST HMNDERHKET FQVRECFGNT PNCPSSSSTN DFQANSGAID AFCQPELDSI STCPNETVSL TTYFSVDSCM TDTYRLKYHQ RPKLSFPESS GFCNNSLS