Details for: DPY30
Gene ID: 84661
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: DPY30
Ensembl ID: ENSG00000162961
Description: dpy-30 histone methyltransferase complex regulatory subunit
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 83.03rCSI 73.01%PRS 26.93
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CSI 58.58rCSI 58.46%PRS 31.05
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CSI 47.2rCSI 54.58%PRS 27.61
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CSI 44.18rCSI 46.17%PRS 36.13
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CSI 28.64rCSI 27.57%PRS 36.72
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CSI 27.75rCSI 63.26%PRS 35.31
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CSI 25.54rCSI 41.38%PRS 35.16
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CSI 21.8rCSI 29.7%PRS 30.96
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CSI 20.84rCSI 70.45%PRS 47.18
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CSI 20.37rCSI 19.64%PRS 27.95
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CSI 19.29rCSI 62.56%PRS 39.65
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CSI 18.99rCSI 35.91%PRS 60.58
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CSI 16.97rCSI 14.07%PRS 34.45
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CSI 16.91rCSI 17.72%PRS 38.11
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CSI 15.43rCSI 19.09%PRS 32.36
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CSI 15.16rCSI 22.42%PRS 40.33
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CSI 15.1rCSI 24.86%PRS 40.94
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CSI 14.06rCSI 16.52%PRS 39.68
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CSI 14.06rCSI 19.15%PRS 64.52
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CSI 13.41rCSI 21.33%PRS 30.55
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CSI 13.26rCSI 16.02%PRS 42.63
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CSI 13.1rCSI 9.74%PRS 48.48
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CSI 12.59rCSI 40.4%PRS 44.43
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CSI 11.69rCSI 8.13%PRS 43.25
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CSI 11.43rCSI 25.64%PRS 23.62
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CSI 11.32rCSI 18.08%PRS 39.12
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CSI 11.12rCSI 19.63%PRS 22.27
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CSI 10.66rCSI 10.87%PRS 47.97
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CSI 10.28rCSI 15.07%PRS 46.01
-
CSI 9.72rCSI 21.39%PRS 39.93
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CSI 9.44rCSI 26.45%PRS 50.99
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CSI 9.24rCSI 6.91%PRS 50.23
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CSI 8.92rCSI 51.16%PRS 46.99
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CSI 8.76rCSI 30.75%PRS 52.23
-
CSI 8.75rCSI 15.43%PRS 44.38
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CSI 8.56rCSI 22.58%PRS 42.46
-
CSI 8.44rCSI 8.3%PRS 38.15
-
CSI 8.37rCSI 10.5%PRS 44.75
-
CSI 8.02rCSI 10.66%PRS 39.83
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CSI 7.87rCSI 15.69%PRS 53.5
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CSI 7.75rCSI 30.86%PRS 52.01
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CSI 7.61rCSI 7.97%PRS 33.69
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CSI 7.52rCSI 6.3%PRS 41.04
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CSI 6.63rCSI 10.28%PRS 46.59
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CSI 6.58rCSI 10.11%PRS 40.65
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CSI 6.4rCSI 28.46%PRS 34.67
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CSI 6.18rCSI 9.55%PRS 34.16
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CSI 6.09rCSI 13.82%PRS 42.17
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CSI 6.05rCSI 8.37%PRS 42.46
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CSI 5.98rCSI 11.63%PRS 37.51
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CSI 5.67rCSI 12.55%PRS 33.42
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CSI 5.61rCSI 5.86%PRS 36.59
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CSI 5.53rCSI 5.73%PRS 41.47
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CSI 5.5rCSI 12.11%PRS 50.42
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CSI 5.5rCSI 15.77%PRS 51.91
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CSI 5.47rCSI 6.32%PRS 31.47
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CSI 5.45rCSI 5.03%PRS 55.99
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CSI 5.21rCSI 3.46%PRS 40.21
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CSI 5.2rCSI 7.68%PRS 52.45
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CSI 5.19rCSI 4.9%PRS 37.17
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CSI 5.15rCSI 3.58%PRS 47.83
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CSI 4.99rCSI 4.51%PRS 33.08
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CSI 4.99rCSI 5.98%PRS 54.77
-
CSI 4.98rCSI 6.92%PRS 36
-
CSI 4.95rCSI 8.73%PRS 35
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CSI 4.94rCSI 38.71%PRS 54.61
-
CSI 4.87rCSI 3.28%PRS 44.66
-
CSI 4.85rCSI 3.64%PRS 38.69
-
CSI 4.81rCSI 27.75%PRS 39.63
-
CSI 4.64rCSI 3.67%PRS 25.68
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CSI 4.61rCSI 6.3%PRS 40.16
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CSI 4.61rCSI 10.63%PRS 29.77
-
CSI 4.47rCSI 16.19%PRS 54.19
-
CSI 4.47rCSI 5.69%PRS 40.68
-
CSI 4.39rCSI 12.95%PRS 40.33
-
CSI 4.29rCSI 5.86%PRS 38.82
-
CSI 4.11rCSI 10.91%PRS 49.51
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CSI 4.05rCSI 3.77%PRS 35.79
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CSI 3.98rCSI 9.09%PRS 31.1
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CSI 3.93rCSI 3.61%PRS 42.34
-
CSI 3.93rCSI 2.99%PRS 45.84
-
CSI 3.92rCSI 7.48%PRS 59.69
-
CSI 3.91rCSI 3.37%PRS 45.81
-
CSI 3.91rCSI 23.04%PRS 24.27
-
CSI 3.82rCSI 2.95%PRS 34.4
-
CSI 3.78rCSI 9.6%PRS 33.53
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CSI 3.76rCSI 3.11%PRS 36.74
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CSI 3.75rCSI 7.52%PRS 27.51
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CSI 3.69rCSI 23.77%PRS 59.11
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CSI 3.68rCSI 7.56%PRS 32.86
-
CSI 3.68rCSI 7.3%PRS 36.15
-
CSI 3.62rCSI 3.73%PRS 52.67
-
CSI 3.36rCSI 2.98%PRS 35.51
-
CSI 3.27rCSI 6.14%PRS 56.92
-
CSI 3.24rCSI 7.24%PRS 41.69
-
CSI 3.23rCSI 4.63%PRS 43.99
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CSI 3.21rCSI 2.53%PRS 41.77
-
CSI 3.2rCSI 4.11%PRS 34.33
-
CSI 3.19rCSI 2.29%PRS 47.65
-
CSI 3.17rCSI 4.64%PRS 36.94
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CSI 0.2rCSI 1.0%PRS 48.4%
-
CSI 0.2rCSI 2.3%PRS 70.6%
-
CSI 0.2rCSI 3.0%PRS 74.7%
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CSI 0.2rCSI 2.3%PRS 65.0%
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CSI 0.3rCSI 0.7%PRS 51.9%
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CSI 0.3rCSI 7.2%PRS 65.6%
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CSI 0.3rCSI 2.9%PRS 64.1%
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CSI 0.3rCSI 1.6%PRS 60.8%
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CSI 0.3rCSI 3.0%PRS 66.5%
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CSI 0.4rCSI 3.4%PRS 79.8%
-
CSI 0.4rCSI 3.2%PRS 78.1%
-
CSI 0.4rCSI 0.5%PRS 45.8%
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CSI 0.4rCSI 2.9%PRS 56.7%
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CSI 0.4rCSI 3.0%PRS 63.7%
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CSI 0.4rCSI 1.3%PRS 24.1%
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CSI 0.4rCSI 10.2%PRS 59.0%
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CSI 0.4rCSI 1.4%PRS 26.1%
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CSI 0.5rCSI 2.1%PRS 53.3%
-
CSI 0.5rCSI 11.5%PRS 91.1%
-
CSI 0.5rCSI 3.1%PRS 73.1%
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CSI 0.5rCSI 1.3%PRS 30.7%
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CSI 0.5rCSI 2.5%PRS 46.5%
-
CSI 0.5rCSI 5.6%PRS 57.1%
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CSI 0.6rCSI 9.3%PRS 71.9%
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CSI 0.6rCSI 2.7%PRS 64.1%
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CSI 0.6rCSI 2.2%PRS 55.3%
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CSI 0.6rCSI 2.2%PRS 74.1%
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CSI 0.6rCSI 4.2%PRS 68.2%
-
CSI 0.7rCSI 3.4%PRS 81.0%
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CSI 0.7rCSI 1.5%PRS 26.5%
-
CSI 0.7rCSI 2.0%PRS 29.0%
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CSI 0.7rCSI 0.6%PRS 44.3%
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CSI 0.7rCSI 2.0%PRS 44.7%
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CSI 0.7rCSI 0.7%PRS 60.1%
-
CSI 0.7rCSI 4.0%PRS 52.5%
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CSI 0.8rCSI 1.9%PRS 22.4%
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CSI 0.8rCSI 2.0%PRS 36.2%
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CSI 0.8rCSI 3.6%PRS 60.6%
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CSI 0.8rCSI 1.9%PRS 52.5%
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CSI 0.8rCSI 2.9%PRS 50.1%
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CSI 0.8rCSI 1.2%PRS 46.8%
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CSI 0.9rCSI 2.5%PRS 54.4%
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CSI 0.9rCSI 1.4%PRS 25.0%
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CSI 0.9rCSI 1.9%PRS 56.5%
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CSI 0.9rCSI 2.3%PRS 28.3%
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CSI 1.0rCSI 5.1%PRS 51.1%
-
CSI 1.0rCSI 2.8%PRS 60.4%
-
CSI 1.0rCSI 7.1%PRS 65.5%
-
CSI 1.0rCSI 2.2%PRS 45.8%
-
CSI 1.0rCSI 5.1%PRS 59.6%
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CSI 1.0rCSI 6.2%PRS 69.7%
-
CSI 1.0rCSI 1.3%PRS 21.8%
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CSI 1.0rCSI 2.0%PRS 66.0%
-
CSI 1.1rCSI 1.6%PRS 42.1%
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CSI 1.1rCSI 2.0%PRS 64.1%
-
CSI 1.2rCSI 1.6%PRS 48.5%
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CSI 1.2rCSI 3.5%PRS 38.8%
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CSI 1.2rCSI 5.4%PRS 56.1%
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CSI 1.2rCSI 1.8%PRS 28.9%
-
CSI 1.2rCSI 1.7%PRS 56.6%
-
CSI 1.3rCSI 1.6%PRS 23.0%
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CSI 1.3rCSI 2.8%PRS 51.0%
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CSI 1.3rCSI 3.4%PRS 33.1%
-
CSI 1.3rCSI 5.8%PRS 31.1%
-
CSI 1.3rCSI 1.7%PRS 49.2%
-
CSI 1.4rCSI 4.7%PRS 73.0%
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CSI 1.4rCSI 3.5%PRS 43.5%
-
CSI 1.4rCSI 3.8%PRS 59.3%
-
CSI 1.5rCSI 2.7%PRS 51.7%
-
CSI 1.5rCSI 3.1%PRS 58.8%
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CSI 1.5rCSI 1.2%PRS 47.1%
-
CSI 1.6rCSI 2.7%PRS 45.2%
-
CSI 1.6rCSI 2.0%PRS 23.9%
-
CSI 1.6rCSI 2.8%PRS 52.1%
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CSI 1.6rCSI 2.5%PRS 36.7%
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CSI 1.6rCSI 1.3%PRS 57.1%
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CSI 1.6rCSI 4.6%PRS 56.9%
-
CSI 1.6rCSI 2.9%PRS 29.4%
-
CSI 1.7rCSI 3.1%PRS 71.4%
-
CSI 1.7rCSI 2.1%PRS 38.4%
-
CSI 1.7rCSI 1.8%PRS 51.9%
-
CSI 1.7rCSI 2.6%PRS 53.4%
-
CSI 1.7rCSI 2.4%PRS 38.6%
-
CSI 1.7rCSI 2.5%PRS 45.9%
-
CSI 1.7rCSI 2.6%PRS 33.4%
-
CSI 1.8rCSI 5.0%PRS 51.1%
-
CSI 1.8rCSI 3.3%PRS 45.0%
-
CSI 1.8rCSI 2.5%PRS 49.8%
-
CSI 1.8rCSI 4.2%PRS 41.9%
-
CSI 1.8rCSI 1.3%PRS 53.9%
-
CSI 1.8rCSI 6.2%PRS 70.1%
-
CSI 1.8rCSI 10.5%PRS 47.4%
-
CSI 1.8rCSI 2.6%PRS 33.7%
-
CSI 1.8rCSI 3.9%PRS 42.8%
-
CSI 1.8rCSI 27.2%PRS 60.3%
-
CSI 1.9rCSI 2.4%PRS 40.6%
-
CSI 1.9rCSI 2.2%PRS 34.5%
-
CSI 1.9rCSI 2.3%PRS 55.3%
-
CSI 1.9rCSI 1.3%PRS 37.7%
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CSI 1.9rCSI 7.3%PRS 30.7%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3332579009
Symbol: DPY30_HUMAN
Name: Protein dpy-30 homolog
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 14992727
Title: Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus.
PubMed ID: 14992727
PubMed ID: 17500065
Title: PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.
PubMed ID: 17500065
PubMed ID: 18838538
Title: Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS.
PubMed ID: 18838538
DOI: 10.1128/mcb.00976-08
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19556245
Title: On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex.
PubMed ID: 19556245
PubMed ID: 19651892
Title: A role of histone H3 lysine 4 methyltransferase components in endosomal trafficking.
PubMed ID: 19651892
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21335234
Title: Role for Dpy-30 in ES cell-fate specification by regulation of H3K4 methylation within bivalent domains.
PubMed ID: 21335234
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 19481096
Title: Crystal structure of the C-terminal domain of human DPY-30-like protein: A component of the histone methyltransferase complex.
PubMed ID: 19481096
Sequence Information:
- Length: 99
- Mass: 11250
- Checksum: 5356AC515B9C2ADB
- Sequence:
MEPEQMLEGQ TQVAENPHSE YGLTDNVERI VENEKINAEK SSKQKVDLQS LPTRAYLDQT VVPILLQGLA VLAKERPPNP IEFLASYLLK NKAQFEDRN
Genular Protein ID: 2079232011
Symbol: B4DIS3_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11181995
Sequence Information:
- Length: 120
- Mass: 13866
- Checksum: 06B191D07C89649B
- Sequence:
MEPEQMLEGQ TQVAENPHSE YGLTDNVERI VENEKINAEK SSKQKVDLQS LPTRAYLDQT VVPILLQGLA VLAKERVLQQ RENTAVKYNL KNSANFSQHC FWTFLRVGSG HLQWLNKYHR