CPNE1 | ENSG00000214078 | NCBI 8904

Details for: CPNE1

Associated with

Glycerophospholipid biosynthesis
(R-HSA-1483206)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Neutrophil degranulation
(R-HSA-6798695)
Phospholipid metabolism
(R-HSA-1483257)
Azurophil granule membrane
(GO:0035577)
Calcium-dependent phospholipid binding
(GO:0005544)
Calcium ion binding
(GO:0005509)
Cellular response to calcium ion
(GO:0071277)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endopeptidase activity
(GO:0004175)
Extracellular exosome
(GO:0070062)
Identical protein binding
(GO:0042802)
Lipid metabolic process
(GO:0006629)
Membrane
(GO:0016020)
Negative regulation of dna binding
(GO:0043392)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of non-canonical nf-kappab signal transduction
(GO:1901223)
Neuron projection extension
(GO:1990138)
Nf-kappab binding
(GO:0051059)
Nuclear membrane
(GO:0031965)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Phosphatidylserine binding
(GO:0001786)
Plasma membrane
(GO:0005886)
Positive regulation of neuron differentiation
(GO:0045666)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of tumor necrosis factor-mediated signaling pathway
(GO:1903265)
Protein binding
(GO:0005515)
Proteolysis
(GO:0006508)
Regulation of canonical nf-kappab signal transduction
(GO:0043122)
Vesicle-mediated transport
(GO:0016192)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

fallopian tube secretory epithelial cell CL4030006

CSI 28.57

rCSI 27.5%

PRS 38.18
CD1c-positive myeloid dendritic cell CL0002399

CSI 13.14

rCSI 15.87%

PRS 44.12
common myeloid progenitor CL0000049

CSI 10.57

rCSI 8.55%

PRS 37.86
renal interstitial pericyte CL1001318

CSI 9.62

rCSI 26.51%

PRS 34.94
effector CD8-positive, alpha-beta T cell CL0001050

CSI 9.43

rCSI 7.18%

PRS 47.6
innate lymphoid cell CL0001065

CSI 9.4

rCSI 19.41%

PRS 45.64
extravillous trophoblast CL0008036

CSI 8.92

rCSI 11.04%

PRS 33.71
transit amplifying cell CL0009010

CSI 8.73

rCSI 13.35%

PRS 53.79
bronchus fibroblast of lung CL2000093

CSI 7.51

rCSI 6.1%

PRS 38.37
VIP GABAergic cortical interneuron CL4023016

CSI 7.3

rCSI 8.72%

PRS 24.06
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 7.27

rCSI 7.14%

PRS 52.12
naive T cell CL0000898

CSI 6.96

rCSI 4.85%

PRS 49.42
mature alpha-beta T cell CL0000791

CSI 6.11

rCSI 22.13%

PRS 55.86
regular ventricular cardiac myocyte CL0002131

CSI 5.9

rCSI 36.86%

PRS 31.02
intestinal tuft cell CL0019032

CSI 5.87

rCSI 8.97%

PRS 41.75
CD14-low, CD16-positive monocyte CL0002396

CSI 5.85

rCSI 4.5%

PRS 35.89
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 5.8

rCSI 29.13%

PRS 47.53
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 5.78

rCSI 14.93%

PRS 34.25
CD16-positive, CD56-dim natural killer cell, human CL0000939

CSI 5.73

rCSI 3.82%

PRS 63.99
inflammatory macrophage CL0000863

CSI 5.69

rCSI 9.72%

PRS 63.78
myeloid lineage restricted progenitor cell CL0000839

CSI 5.59

rCSI 28.87%

PRS 61.27
epithelial cell of lower respiratory tract CL0002632

CSI 5.54

rCSI 4.29%

PRS 37.37
common dendritic progenitor CL0001029

CSI 5.41

rCSI 6.79%

PRS 46.43
enterocyte CL0000584

CSI 5.07

rCSI 8.18%

PRS 47.6
respiratory suprabasal cell CL4033048

CSI 4.78

rCSI 6.13%

PRS 41.92
skin fibroblast CL0002620

CSI 4.67

rCSI 4.03%

PRS 47.06
peripheral nervous system neuron CL2000032

CSI 4.66

rCSI 6.35%

PRS 32.21
colon goblet cell CL0009039

CSI 4.62

rCSI 10.99%

PRS 50.04
unswitched memory B cell CL0000970

CSI 4.41

rCSI 3.71%

PRS 54.06
squamous epithelial cell CL0000076

CSI 4.31

rCSI 10.23%

PRS 43.24
kidney connecting tubule epithelial cell CL1000768

CSI 4.29

rCSI 10.87%

PRS 29.46
Kupffer cell CL0000091

CSI 4.16

rCSI 9.52%

PRS 36.88
ciliated cell CL0000064

CSI 4.11

rCSI 6.66%

PRS 36.45
pro-B cell CL0000826

CSI 4.07

rCSI 3.37%

PRS 38.23
effector CD4-positive, alpha-beta T cell CL0001044

CSI 4.03

rCSI 11.56%

PRS 53.59
retinal rod cell CL0000604

CSI 4

rCSI 7.05%

PRS 36.34
fraction A pre-pro B cell CL0002045

CSI 3.96

rCSI 4.53%

PRS 60.53
paneth cell CL0000510

CSI 3.93

rCSI 5.81%

PRS 54.13
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 3.53

rCSI 3.21%

PRS 51.98
perivascular cell CL4033054

CSI 3.52

rCSI 4.81%

PRS 41.83
astrocyte of the cerebral cortex CL0002605

CSI 3.38

rCSI 7.57%

PRS 24.64
memory T cell CL0000813

CSI 3.35

rCSI 6.45%

PRS 67.33
pulmonary ionocyte CL0017000

CSI 3.27

rCSI 3.98%

PRS 44.57
myeloid leukocyte CL0000766

CSI 3.2

rCSI 2.95%

PRS 38.51
hematopoietic stem cell CL0000037

CSI 3.07

rCSI 2.04%

PRS 41.55
myelocyte CL0002193

CSI 2.84

rCSI 18.65%

PRS 72.57
lymphoid lineage restricted progenitor cell CL0000838

CSI 2.81

rCSI 10.95%

PRS 56.85
rod bipolar cell CL0000751

CSI 2.81

rCSI 5.05%

PRS 31.81
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 2.79

rCSI 2.09%

PRS 70.95
CD4-positive, alpha-beta memory T cell CL0000897

CSI 2.75

rCSI 1.98%

PRS 49.21
eosinophil CL0000771

CSI 2.61

rCSI 17.15%

PRS 69.46
vascular leptomeningeal cell CL4023051

CSI 2.6

rCSI 4.55%

PRS 30.67
podocyte CL0000653

CSI 2.56

rCSI 11.37%

PRS 36.11
early lymphoid progenitor CL0000936

CSI 2.53

rCSI 2.22%

PRS 42.2
double negative thymocyte CL0002489

CSI 2.52

rCSI 1.75%

PRS 44.9
T-helper 17 cell CL0000899

CSI 2.47

rCSI 1.96%

PRS 58.71
melanocyte CL0000148

CSI 2.45

rCSI 1.82%

PRS 32.17
M cell of gut CL0000682

CSI 2.35

rCSI 2.5%

PRS 53.37
lung secretory cell CL1000272

CSI 2.35

rCSI 5.81%

PRS 35.64
mature T cell CL0002419

CSI 2.29

rCSI 1.78%

PRS 52.88
hematopoietic precursor cell CL0008001

CSI 2.22

rCSI 2.29%

PRS 54.52
CD4-positive, alpha-beta thymocyte CL0000810

CSI 2.2

rCSI 1.76%

PRS 58.37
colon epithelial cell CL0011108

CSI 2.2

rCSI 2.3%

PRS 35.13
hepatocyte CL0000182

CSI 2.15

rCSI 3.85%

PRS 35.81
brush cell of tracheobronchial tree CL0002075

CSI 2.14

rCSI 6.34%

PRS 48.6
small pre-B-II cell CL0000954

CSI 2.14

rCSI 2.05%

PRS 61.44
retinal pigment epithelial cell CL0002586

CSI 2.13

rCSI 4.24%

PRS 37.51
plasmablast CL0000980

CSI 2.1

rCSI 1.65%

PRS 43.36
sncg GABAergic cortical interneuron CL4023015

CSI 2.09

rCSI 3.36%

PRS 26.02
midzonal region hepatocyte CL0019028

CSI 2.08

rCSI 4.89%

PRS 47.08
plasmacytoid dendritic cell, human CL0001058

CSI 2.07

rCSI 1.45%

PRS 39.19
stem cell CL0000034

CSI 2.01

rCSI 1.93%

PRS 29.24
secretory cell CL0000151

CSI 1.96

rCSI 2.04%

PRS 38.03
cerebral cortex GABAergic interneuron CL0010011

CSI 1.93

rCSI 5.71%

PRS 41.79
pvalb GABAergic cortical interneuron CL4023018

CSI 1.92

rCSI 2.39%

PRS 22.82
erythroid progenitor cell CL0000038

CSI 1.9

rCSI 10.89%

PRS 48.49
pancreatic D cell CL0000173

CSI 1.9

rCSI 1.87%

PRS 39.69
L6b glutamatergic cortical neuron CL4023038

CSI 1.9

rCSI 5.94%

PRS 25.15
common lymphoid progenitor CL0000051

CSI 1.89

rCSI 2.53%

PRS 59.8
pulmonary capillary endothelial cell CL4028001

CSI 1.87

rCSI 3.58%

PRS 53.98
interstitial cell of Cajal CL0002088

CSI 1.84

rCSI 2.34%

PRS 42.27
lung pericyte CL0009089

CSI 1.82

rCSI 4.81%

PRS 44.09
fibroblast of lung CL0002553

CSI 1.82

rCSI 1.69%

PRS 37.25
precursor B cell CL0000817

CSI 1.81

rCSI 1.59%

PRS 46.67
lung macrophage CL1001603

CSI 1.81

rCSI 4.05%

PRS 43.32
epithelial cell of lung CL0000082

CSI 1.79

rCSI 1.49%

PRS 35.98
respiratory hillock cell CL4030023

CSI 1.78

rCSI 3.18%

PRS 53.55
hepatic stellate cell CL0000632

CSI 1.77

rCSI 6.64%

PRS 31.83
ionocyte CL0005006

CSI 1.76

rCSI 1.88%

PRS 35.25
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 1.75

rCSI 2.41%

PRS 57.96
alpha-beta T cell CL0000789

CSI 1.74

rCSI 2.04%

PRS 51.43
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 1.73

rCSI 2.45%

PRS 34.98
CD4-positive helper T cell CL0000492

CSI 1.73

rCSI 1.31%

PRS 48.77
mucous neck cell CL0000651

CSI 1.72

rCSI 2.48%

PRS 51.27
immature B cell CL0000816

CSI 1.7

rCSI 1.26%

PRS 49.94
Mueller cell CL0000636

CSI 1.7

rCSI 3.88%

PRS 32.2
granulocyte monocyte progenitor cell CL0000557

CSI 1.7

rCSI 1.47%

PRS 41.1
adventitial cell CL0002503

CSI 1.67

rCSI 3.98%

PRS 48.69
elicited macrophage CL0000861

CSI 1.66

rCSI 1.53%

PRS 44
vascular associated smooth muscle cell CL0000359

CSI 1.65

rCSI 5.34%

PRS 41.12

pre-conventional dendritic cell CL0002010

CSI 0.2

rCSI 2.0%

PRS 71.8%
CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human CL0001074

CSI 0.2

rCSI 2.1%

PRS 76.3%
P/D1 enteroendocrine cell CL0002268

CSI 0.2

rCSI 1.2%

PRS 61.6%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 0.2

rCSI 0.7%

PRS 27.2%
enteric neuron CL0007011

CSI 0.2

rCSI 3.3%

PRS 61.4%
tracheobronchial serous cell CL0019001

CSI 0.3

rCSI 1.1%

PRS 54.7%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 0.3

rCSI 1.5%

PRS 25.3%
respiratory goblet cell CL0002370

CSI 0.3

rCSI 3.0%

PRS 58.6%
megakaryocyte CL0000556

CSI 0.3

rCSI 1.3%

PRS 53.7%
parietal epithelial cell CL1000452

CSI 0.3

rCSI 0.8%

PRS 31.7%
vein endothelial cell of respiratory system CL4033008

CSI 0.4

rCSI 2.5%

PRS 57.3%
corneal epithelial cell CL0000575

CSI 0.4

rCSI 1.1%

PRS 55.5%
cardiac muscle cell CL0000746

CSI 0.4

rCSI 0.6%

PRS 30.1%
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 0.5

rCSI 1.1%

PRS 28.4%
retinal ganglion cell CL0000740

CSI 0.5

rCSI 1.0%

PRS 27.7%
CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell CL0000915

CSI 0.5

rCSI 2.1%

PRS 74.8%
melanocyte of skin CL1000458

CSI 0.5

rCSI 0.7%

PRS 20.0%
retinal cone cell CL0000573

CSI 0.5

rCSI 0.9%

PRS 29.5%
forebrain radial glial cell CL0013000

CSI 0.6

rCSI 1.8%

PRS 45.8%
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 0.6

rCSI 1.1%

PRS 55.1%
stromal cell of ovary CL0002132

CSI 0.6

rCSI 1.5%

PRS 53.2%
bronchial goblet cell CL1000312

CSI 0.6

rCSI 2.2%

PRS 59.8%
pancreatic PP cell CL0002275

CSI 0.6

rCSI 2.2%

PRS 53.5%
basophil mast progenitor cell CL0002028

CSI 0.6

rCSI 3.0%

PRS 77.8%
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 0.6

rCSI 0.7%

PRS 36.4%
alveolar adventitial fibroblast CL4028006

CSI 0.6

rCSI 0.9%

PRS 38.3%
hematopoietic multipotent progenitor cell CL0000837

CSI 0.6

rCSI 1.5%

PRS 54.3%
near-projecting glutamatergic cortical neuron CL4023012

CSI 0.6

rCSI 2.3%

PRS 25.0%
duct epithelial cell CL0000068

CSI 0.6

rCSI 0.9%

PRS 40.0%
glycinergic amacrine cell CL4030028

CSI 0.6

rCSI 1.6%

PRS 37.6%
neural progenitor cell CL0011020

CSI 0.6

rCSI 2.8%

PRS 32.4%
respiratory basal cell CL0002633

CSI 0.7

rCSI 0.7%

PRS 42.9%
lamp5 GABAergic cortical interneuron CL4023011

CSI 0.7

rCSI 1.1%

PRS 24.1%
promonocyte CL0000559

CSI 0.7

rCSI 1.2%

PRS 46.6%
type B pancreatic cell CL0000169

CSI 0.7

rCSI 1.5%

PRS 34.9%
helper T cell CL0000912

CSI 0.7

rCSI 1.0%

PRS 47.1%
intraepithelial lymphocyte CL0002496

CSI 0.7

rCSI 1.9%

PRS 78.1%
mesenchymal stem cell CL0000134

CSI 0.7

rCSI 7.9%

PRS 54.8%
pancreatic stellate cell CL0002410

CSI 0.7

rCSI 4.2%

PRS 48.7%
microcirculation associated smooth muscle cell CL0008035

CSI 0.7

rCSI 2.1%

PRS 40.2%
deuterosomal cell CL4033044

CSI 0.7

rCSI 2.5%

PRS 48.5%
multi-ciliated epithelial cell CL0005012

CSI 0.7

rCSI 0.7%

PRS 32.3%
indirect pathway medium spiny neuron CL4023029

CSI 0.8

rCSI 18.3%

PRS 24.4%
keratocyte CL0002363

CSI 0.8

rCSI 1.8%

PRS 48.3%
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 0.8

rCSI 1.0%

PRS 56.9%
germinal center B cell CL0000844

CSI 0.9

rCSI 2.5%

PRS 61.5%
mesodermal cell CL0000222

CSI 0.9

rCSI 1.0%

PRS 35.9%
Langerhans cell CL0000453

CSI 0.9

rCSI 1.3%

PRS 55.0%
dendritic cell, human CL0001056

CSI 0.9

rCSI 1.3%

PRS 43.7%
acinar cell CL0000622

CSI 0.9

rCSI 1.3%

PRS 47.8%
thymocyte CL0000893

CSI 0.9

rCSI 3.2%

PRS 75.4%
pancreatic ductal cell CL0002079

CSI 0.9

rCSI 1.8%

PRS 39.0%
endothelial cell of placenta CL0009092

CSI 0.9

rCSI 4.5%

PRS 48.3%
tracheobronchial smooth muscle cell CL0019019

CSI 0.9

rCSI 1.6%

PRS 45.9%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 0.9

rCSI 3.3%

PRS 23.1%
promyelocyte CL0000836

CSI 0.9

rCSI 1.4%

PRS 47.4%
pluripotent stem cell CL0002248

CSI 0.9

rCSI 28.3%

PRS 62.9%
chondrocyte CL0000138

CSI 1.0

rCSI 1.5%

PRS 31.7%
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 1.0

rCSI 1.3%

PRS 65.7%
T-helper 1 cell CL0000545

CSI 1.0

rCSI 1.8%

PRS 65.2%
late pro-B cell CL0002048

CSI 1.0

rCSI 2.5%

PRS 69.4%
natural T-regulatory cell CL0000903

CSI 1.0

rCSI 1.9%

PRS 72.4%
granulocyte CL0000094

CSI 1.0

rCSI 1.5%

PRS 46.0%
large pre-B-II cell CL0000957

CSI 1.0

rCSI 2.9%

PRS 52.5%
colonocyte CL1000347

CSI 1.0

rCSI 1.4%

PRS 45.3%
muscle cell CL0000187

CSI 1.0

rCSI 2.1%

PRS 60.2%
glioblast CL0000030

CSI 1.0

rCSI 1.6%

PRS 32.3%
cytotoxic T cell CL0000910

CSI 1.0

rCSI 5.8%

PRS 49.8%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 1.1

rCSI 1.9%

PRS 23.3%
club cell CL0000158

CSI 1.1

rCSI 1.6%

PRS 38.1%
alternatively activated macrophage CL0000890

CSI 1.1

rCSI 1.4%

PRS 50.6%
mammary gland epithelial cell CL0002327

CSI 1.1

rCSI 3.8%

PRS 53.6%
IgG plasma cell CL0000985

CSI 1.1

rCSI 1.3%

PRS 56.2%
cardiac endothelial cell CL0010008

CSI 1.1

rCSI 4.4%

PRS 36.1%
contractile cell CL0000183

CSI 1.1

rCSI 3.2%

PRS 36.2%
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 1.1

rCSI 3.4%

PRS 49.6%
retinal bipolar neuron CL0000748

CSI 1.1

rCSI 2.1%

PRS 28.7%
megakaryocyte progenitor cell CL0000553

CSI 1.1

rCSI 20.6%

PRS 73.3%
renal beta-intercalated cell CL0002201

CSI 1.1

rCSI 2.7%

PRS 40.2%
cerebral cortex endothelial cell CL1001602

CSI 1.1

rCSI 2.0%

PRS 29.4%
primitive red blood cell CL0002355

CSI 1.1

rCSI 6.2%

PRS 52.6%
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 1.2

rCSI 1.3%

PRS 32.7%
mononuclear phagocyte CL0000113

CSI 1.2

rCSI 2.6%

PRS 41.3%
ciliated epithelial cell CL0000067

CSI 1.2

rCSI 1.0%

PRS 28.1%
ON-bipolar cell CL0000749

CSI 1.2

rCSI 1.7%

PRS 40.8%
transit amplifying cell of colon CL0009011

CSI 1.2

rCSI 1.4%

PRS 41.2%
transitional stage B cell CL0000818

CSI 1.2

rCSI 3.9%

PRS 70.6%
basal-myoepithelial cell of mammary gland CL0002324

CSI 1.2

rCSI 2.3%

PRS 61.8%
enteroendocrine cell CL0000164

CSI 1.2

rCSI 1.6%

PRS 40.3%
mesenchymal cell CL0008019

CSI 1.2

rCSI 3.1%

PRS 34.8%
CD8-positive, alpha-beta thymocyte CL0000811

CSI 1.2

rCSI 1.9%

PRS 64.4%
conjunctival epithelial cell CL1000432

CSI 1.2

rCSI 1.9%

PRS 37.8%
double-positive, alpha-beta thymocyte CL0000809

CSI 1.2

rCSI 1.3%

PRS 49.6%
goblet cell CL0000160

CSI 1.2

rCSI 1.2%

PRS 38.6%
renal alpha-intercalated cell CL0005011

CSI 1.2

rCSI 1.6%

PRS 45.2%
pancreatic acinar cell CL0002064

CSI 1.2

rCSI 1.6%

PRS 41.5%
enteric smooth muscle cell CL0002504

CSI 1.3

rCSI 1.8%

PRS 40.2%
pancreatic A cell CL0000171

CSI 1.3

rCSI 1.3%

PRS 39.7%
enteroendocrine cell of small intestine CL0009006

CSI 1.3

rCSI 2.8%

PRS 52.0%
kidney interstitial alternatively activated macrophage CL1000695

CSI 1.3

rCSI 3.3%

PRS 36.5%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

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Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [CPNE1](/details-gene/8904) (Copine 1) is a protein-coding gene located on chromosome 20q11.22. It belongs to a conserved family of proteins characterized by the presence of two N-terminal C2 domains and a C-terminal A-domain, which collectively mediate calcium-dependent phospholipid binding [Link](https://doi.org/10.1074/jbc.273.3.1393). This core function enables [CPNE1](/details-gene/8904) to participate in a wide range of cellular processes, including signal transduction, vesicle-mediated transport, and gene expression regulation. Expression data reveals its significance in a diverse array of cell types, with exceptionally high levels in [fallopian tube secretory epithelial cell](/details-cell/CL4030006) and prominent roles within both the innate and adaptive immune systems, particularly in myeloid and T cell lineages. Its function is pleiotropic, implicated in regulating NF-kappaB signaling, promoting neuronal differentiation, and participating in metabolic pathways. ## Cellular Roles and Expression Landscape The expression profile of [CPNE1](/details-gene/8904) suggests a broad but functionally specific role across multiple tissues. **Overall**, its most striking significance is observed in [fallopian tube secretory epithelial cell](/details-cell/CL4030006) (CSI: 28.57), where its expression level is substantially higher than in any other cell type, pointing towards a specialized function in the reproductive system. Beyond this epithelial context, [CPNE1](/details-gene/8904) is a key protein in the immune system. It shows high significance in myeloid lineage cells, including [CD1c-positive myeloid dendritic cell](/details-cell/CL0002399) and [common myeloid progenitor](/details-cell/CL0000049). This is consistent with initial studies identifying Copine I in the cytosol of human neutrophils [Link](https://doi.org/10.1189/jlb.0203083). The gene is also prominent across the T cell compartment, including in [effector CD8-positive, alpha-beta T cell](/details-cell/CL0001050), [CD4-positive, CD25-positive, alpha-beta regulatory T cell](/details-cell/CL0000792), [naive T cell](/details-cell/CL0000898), and [mature alpha-beta T cell](/details-cell/CL0000791), as well as in [innate lymphoid cell](/details-cell/CL0001065). Furthermore, [CPNE1](/details-gene/8904) demonstrates functional relevance in various other specialized cell types. Its significance in [VIP GABAergic cortical interneuron](/details-cell/CL4023016) aligns with research demonstrating its role in promoting neuronal differentiation [Link](https://doi.org/10.1007/s10059-012-0235-7). Additionally, its expression in mesenchymal cell types like [renal interstitial pericyte](/details-cell/CL1001318) and [bronchus fibroblast of lung](/details-cell/CL2000093) suggests involvement in tissue homeostasis and structural cell function. ## Pathways and Molecular Function The molecular functions of [CPNE1](/details-gene/8904) are intrinsically linked to its ability to bind calcium and phospholipids. Its primary molecular function is defined by Gene Ontology terms such as '[Calcium ion binding](/details-cell/GO:0005509)' and '[Calcium-dependent phospholipid binding](/details-cell/GO:0005544)'. This allows it to translocate to cellular membranes in response to calcium signals, where it can interact with other proteins and regulate downstream events. A critical role for [CPNE1](/details-gene/8904) is in the modulation of inflammatory signaling pathways. It is involved in the '[Regulation of canonical nf-kappab signal transduction](/details-cell/GO:0043122)' and the '[Positive regulation of tumor necrosis factor-mediated signaling pathway](/details-cell/GO:1903265)'. Research indicates that [CPNE1](/details-gene/8904) can directly regulate TNF-alpha receptor signaling [Link](https://doi.org/10.1042/bj20031654) and can also repress NF-kappaB-mediated transcription through the endoproteolysis of the p65 subunit [Link](https://doi.org/10.1038/sj.onc.1211030). This function is highly relevant to its expression in immune cells. Indeed, its annotation in Reactome's '[Neutrophil degranulation](/details-cell/R-HSA-6798695)' pathway and its localization to the '[Azurophil granule membrane](/details-cell/GO:0035577)' highlight its specific role in innate immunity. Consistent with its expression in neuronal cells, [CPNE1](/details-gene/8904) is associated with '[Positive regulation of neuron differentiation](/details-cell/GO:0045666)' and '[Neuron projection extension](/details-cell/GO:1990138)'. Studies have shown that [CPNE1](/details-gene/8904) enhances the differentiation of hippocampal progenitor cells, a function that may involve both calcium-dependent and independent activities of its C2 domains [Link](https://doi.org/10.1016/j.bbrc.2014.10.075). The gene is also linked to lipid metabolism, including '[Glycerophospholipid biosynthesis](/details-cell/R-HSA-1483206)', which may be related to its membrane-binding properties. ## Research Directions The diverse expression pattern and multifaceted functions of [CPNE1](/details-gene/8904) present several avenues for future investigation. Its role as a modulator of NF-kappaB and its high expression in immune cells suggest it is a key regulator of inflammation, while its unique prominence in fallopian tube epithelium remains poorly understood. Based on the available data, the following hypotheses can be proposed: 1. **Hypothesis 1:** In immune cells, [CPNE1](/details-gene/8904) acts as a crucial negative feedback regulator of inflammation. Following activation by stimuli like TNF-alpha or LPS, induced calcium flux recruits [CPNE1](/details-gene/8904) to sites of NF-kappaB activity, where it proteolytically cleaves p65 to terminate the inflammatory response and prevent excessive tissue damage. 2. **Hypothesis 2:** In [fallopian tube secretory epithelial cell](/details-cell/CL4030006), [CPNE1](/details-gene/8904) is essential for calcium-regulated exocytosis of factors that constitute the tubal fluid. This secretion is likely critical for creating a microenvironment that supports gamete viability, fertilization, and early embryonic development. **Experimental Approach to Test Hypothesis 1:** To investigate the role of [CPNE1](/details-gene/8904) as a negative regulator of NF-kappaB, one could utilize a CRISPR-Cas9 knockout strategy in a human monocytic cell line (e.g., THP-1). Wild-type and [CPNE1](/details-gene/8904)-knockout cells would be stimulated with LPS. The dynamics of the inflammatory response could be assessed by measuring the phosphorylation and total protein levels of p65 over a time course using Western blot. Furthermore, the transcriptional output could be quantified by measuring mRNA levels of key NF-kappaB target genes (e.g., *TNF*, *IL6*, *CXCL8*) via RT-qPCR. A sustained or exaggerated inflammatory response in the knockout cells compared to wild-type would support the hypothesis that [CPNE1](/details-gene/8904) is a key brake on the NF-kappaB pathway. **Therapeutic Potential:** The role of [CPNE1](/details-gene/8904) in repressing NF-kappaB signaling makes it an intriguing therapeutic target. For autoimmune and chronic inflammatory diseases characterized by excessive NF-kappaB activation, developing small molecules or biologics that enhance the stability or proteolytic activity of [CPNE1](/details-gene/8904) could represent a novel anti-inflammatory strategy. Conversely, because it can degrade the p65 subunit, its loss may contribute to oncogenesis in certain contexts, suggesting it could function as a tumor suppressor. Therefore, assessing [CPNE1](/details-gene/8904) expression could serve as a prognostic biomarker, and strategies to restore its function could have therapeutic value in specific cancers.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

CPNE1_HUMAN
B0QZ18_HUMAN

Genular Protein ID: 227514241

Symbol: CPNE1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q99829 E1P5Q4 Q6IBL3 Q9H243 Q9NTZ7

Database IDs:

Citations:

PubMed ID: 9430674

Title: The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans.

PubMed ID: 9430674

DOI: 10.1074/jbc.273.3.1393

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12522145

Title: Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif.

PubMed ID: 12522145

DOI: 10.1074/jbc.m212632200

PubMed ID: 12949241

Title: Tissue expression of copines and isolation of copines I and III from the cytosol of human neutrophils.

PubMed ID: 12949241

DOI: 10.1189/jlb.0203083

PubMed ID: 14674885

Title: Calcium-dependent regulation of tumour necrosis factor-alpha receptor signalling by copine.

PubMed ID: 14674885

DOI: 10.1042/bj20031654

PubMed ID: 18212740

Title: Copine-I represses NF-kappaB transcription by endoproteolysis of p65.

PubMed ID: 18212740

DOI: 10.1038/sj.onc.1211030

PubMed ID: 19539605

Title: Organization and synergistic binding of copine I and annexin A1 on supported lipid bilayers observed by atomic force microscopy.

PubMed ID: 19539605

DOI: 10.1016/j.bbamem.2009.06.009

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21087455

Title: Copines-1, -2, -3, -6 and -7 show different calcium-dependent intracellular membrane translocation and targeting.

PubMed ID: 21087455

DOI: 10.1111/j.1742-4658.2010.07935.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23263657

Title: Copine1 enhances neuronal differentiation of the hippocampal progenitor HiB5 cells.

PubMed ID: 23263657

DOI: 10.1007/s10059-012-0235-7

PubMed ID: 25450385

Title: Copine1 C2 domains have a critical calcium-independent role in the neuronal differentiation of hippocampal progenitor HiB5 cells.

PubMed ID: 25450385

DOI: 10.1016/j.bbrc.2014.10.075

Sequence Information:

Length: 537
Mass: 59059
Checksum: F078D9046C2AAB06
Sequence:

MAHCVTLVQL SISCDHLIDK DIGSKSDPLC VLLQDVGGGS WAELGRTERV RNCSSPEFSK 
TLQLEYRFET VQKLRFGIYD IDNKTPELRD DDFLGGAECS LGQIVSSQVL TLPLMLKPGK 
PAGRGTITVS AQELKDNRVV TMEVEARNLD KKDFLGKSDP FLEFFRQGDG KWHLVYRSEV 
IKNNLNPTWK RFSVPVQHFC GGNPSTPIQV QCSDYDSDGS HDLIGTFHTS LAQLQAVPAE 
FECIHPEKQQ KKKSYKNSGT IRVKICRVET EYSFLDYVMG GCQINFTVGV DFTGSNGDPS 
SPDSLHYLSP TGVNEYLMAL WSVGSVVQDY DSDKLFPAFG FGAQVPPDWQ VSHEFALNFN 
PSNPYCAGIQ GIVDAYRQAL PQVRLYGPTN FAPIINHVAR FAAQAAHQGT ASQYFMLLLL 
TDGAVTDVEA TREAVVRASN LPMSVIIVGV GGADFEAMEQ LDADGGPLHT RSGQAAARDI 
VQFVPYRRFQ NAPREALAQT VLAEVPTQLV SYFRAQGWAP LKPLPPSAKD PAQAPQA

Genular Protein ID: 2071688462

Symbol: B0QZ18_HUMAN

Name: N/A

UniProtKB Accession Codes:

B0QZ18

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

Length: 542
Mass: 59718
Checksum: 9AEFE6F5B8955489
Sequence:

MKMMHMAHCV TLVQLSISCD HLIDKDIGSK SDPLCVLLQD VGGGSWAELG RTERVRNCSS 
PEFSKTLQLE YRFETVQKLR FGIYDIDNKT PELRDDDFLG GAECSLGQIV SSQVLTLPLM 
LKPGKPAGRG TITVSAQELK DNRVVTMEVE ARNLDKKDFL GKSDPFLEFF RQGDGKWHLV 
YRSEVIKNNL NPTWKRFSVP VQHFCGGNPS TPIQVQCSDY DSDGSHDLIG TFHTSLAQLQ 
AVPAEFECIH PEKQQKKKSY KNSGTIRVKI CRVETEYSFL DYVMGGCQIN FTVGVDFTGS 
NGDPSSPDSL HYLSPTGVNE YLMALWSVGS VVQDYDSDKL FPAFGFGAQV PPDWQVSHEF 
ALNFNPSNPY CAGIQGIVDA YRQALPQVRL YGPTNFAPII NHVARFAAQA AHQGTASQYF 
MLLLLTDGAV TDVEATREAV VRASNLPMSV IIVGVGGADF EAMEQLDADG GPLHTRSGQA 
AARDIVQFVP YRRFQNAPRE ALAQTVLAEV PTQLVSYFRA QGWAPLKPLP PSAKDPAQAP 
QA

	Overall overall
	Acute kidney failure MONDO0002492
	Adrenal gland UBERON0002369
	Alzheimer disease MONDO0004975
	Basal cell carcinoma MONDO0020804
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	\|— Brain Healthy UBERON0000955_PATO0000461
	Breast UBERON0000310
	\|— Breast Healthy UBERON0000310_PATO0000461
	\|— Breast cancer MONDO0007254
	Bronchus UBERON0002185
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Cerebrospinal fluid UBERON0001359
	Choroid plexus UBERON0001886
	Colon UBERON0001155
	\|— Colon Healthy UBERON0001155_PATO0000461
	Colorectal cancer MONDO0005575
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	Duodenum UBERON0002114
	\|— Duodenum Healthy UBERON0002114_PATO0000461
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Heart right ventricle UBERON0002080
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	\|— Ileum lamina propria UBERON8600035
	Interventricular septum UBERON0002094
	Islet of Langerhans UBERON0000006
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Lamina propria of small intestine UBERON0001238
	Liver UBERON0002107
	\|— Liver Healthy UBERON0002107_PATO0000461
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung adenocarcinoma MONDO0005061
	Lymph node UBERON0000029
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Nasopharynx UBERON0001728
	Neocortex UBERON0001950
	\|— Neocortex Healthy UBERON0001950_PATO0000461
	Neuroblastoma MONDO0005072
	Ovary UBERON0000992
	\|— Ovary Healthy UBERON0000992_PATO0000461
	Placenta UBERON0001987
	Pleural effusion UBERON0000175
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Prefrontal cortex UBERON0000451
	Renal medulla UBERON0000362
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Schizophrenia MONDO0005090
	Sigmoid colon UBERON0001159
	Skin of body UBERON0002097
	Small cell lung carcinoma MONDO0008433
	Spleen UBERON0002106
	\|— Spleen Healthy UBERON0002106_PATO0000461
	Telencephalon UBERON0001893
	\|— Telencephalon Healthy UBERON0001893_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	Thymus UBERON0002370
	\|— Thymus Healthy UBERON0002370_PATO0000461
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Upper lobe of left lung UBERON0008952

Details for: CPNE1

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans. PubMed ID: 9430674

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif. PubMed ID: 12522145

Tissue expression of copines and isolation of copines I and III from the cytosol of human neutrophils. PubMed ID: 12949241

Calcium-dependent regulation of tumour necrosis factor-alpha receptor signalling by copine. PubMed ID: 14674885

Copine-I represses NF-kappaB transcription by endoproteolysis of p65. PubMed ID: 18212740

Organization and synergistic binding of copine I and annexin A1 on supported lipid bilayers observed by atomic force microscopy. PubMed ID: 19539605

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Copines-1, -2, -3, -6 and -7 show different calcium-dependent intracellular membrane translocation and targeting. PubMed ID: 21087455

Initial characterization of the human central proteome. PubMed ID: 21269460

Copine1 enhances neuronal differentiation of the hippocampal progenitor HiB5 cells. PubMed ID: 23263657

Copine1 C2 domains have a critical calcium-independent role in the neuronal differentiation of hippocampal progenitor HiB5 cells. PubMed ID: 25450385

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The sequence of the human genome. PubMed ID: 11181995

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

PubMed ID: 9430674

PubMed ID: 11780052

PubMed ID: 15489334

PubMed ID: 12522145

PubMed ID: 12949241

PubMed ID: 14674885

PubMed ID: 18212740

PubMed ID: 19539605

PubMed ID: 19608861

PubMed ID: 21087455

PubMed ID: 21269460

PubMed ID: 23263657

PubMed ID: 25450385

PubMed ID: 11237011

PubMed ID: 11780052

PubMed ID: 11181995

PubMed ID: 15496913

PubMed ID: 19608861

PubMed ID: 21269460