Details for: AKR1A1
Gene ID: 10327
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: AKR1A1
Ensembl ID: ENSG00000117448
Description: aldo-keto reductase family 1 member A1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 52.42rCSI 54.79%PRS 13.4
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CSI 51.09rCSI 49.26%PRS 8.76
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CSI 39.24rCSI 26.08%PRS 15.17
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CSI 35.59rCSI 41.8%PRS 14.98
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CSI 34.28rCSI 74.83%PRS 25.61
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CSI 33.49rCSI 35.08%PRS 11.86
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CSI 32.42rCSI 52.27%PRS 20.36
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CSI 30.82rCSI 44.42%PRS 20.51
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CSI 29.55rCSI 23.89%PRS 12.56
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CSI 29.34rCSI 23.08%PRS 15.11
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CSI 28.91rCSI 30.72%PRS 22.62
-
CSI 27.59rCSI 39.55%PRS 17.46
-
CSI 26.85rCSI 24.66%PRS 14.56
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CSI 25.62rCSI 23.64%PRS 12.9
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CSI 24.72rCSI 21.95%PRS 12.75
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CSI 24.44rCSI 32.48%PRS 13.91
-
CSI 24.08rCSI 21.74%PRS 11.25
-
CSI 23.87rCSI 46.41%PRS 12.99
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CSI 22.71rCSI 18.83%PRS 12
-
CSI 22.46rCSI 47.81%PRS 20.5
-
CSI 21.35rCSI 27.38%PRS 14.7
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CSI 20.74rCSI 24.05%PRS 18.79
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CSI 19.76rCSI 37.72%PRS 29.89
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CSI 19.72rCSI 28.89%PRS 14.87
-
CSI 16.56rCSI 15.94%PRS 13.18
-
CSI 16.01rCSI 39.11%PRS 12.7
-
CSI 14.76rCSI 35.08%PRS 19.17
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CSI 14.71rCSI 58.77%PRS 27.86
-
CSI 14.52rCSI 14.49%PRS 10.87
-
CSI 14.4rCSI 18.07%PRS 16.2
-
CSI 13.57rCSI 11.75%PRS 14.17
-
CSI 13.21rCSI 9.19%PRS 14.9
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CSI 12.63rCSI 20.81%PRS 14.82
-
CSI 12.63rCSI 11.93%PRS 13.3
-
CSI 12.38rCSI 54.35%PRS 23.72
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CSI 12.35rCSI 9.89%PRS 23.08
-
CSI 11.99rCSI 10.54%PRS 9.23
-
CSI 11.77rCSI 32.98%PRS 19.67
-
CSI 11.65rCSI 9.47%PRS 13.44
-
CSI 11.57rCSI 16.96%PRS 16.69
-
CSI 11.46rCSI 17.53%PRS 20.71
-
CSI 11.21rCSI 17.38%PRS 19.34
-
CSI 10.58rCSI 74.67%PRS 38.73
-
CSI 10.15rCSI 15.01%PRS 14.68
-
CSI 10.04rCSI 13.15%PRS 53.06
-
CSI 10.04rCSI 15.85%PRS 12.72
-
CSI 9.9rCSI 15.21%PRS 18.12
-
CSI 9.67rCSI 49.95%PRS 25
-
CSI 9.64rCSI 15.3%PRS 16.42
-
CSI 9.45rCSI 25.47%PRS 16.38
-
CSI 8.9rCSI 15.2%PRS 25.54
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CSI 8.79rCSI 11.52%PRS 17.81
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CSI 8.75rCSI 7.69%PRS 14.3
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CSI 8.73rCSI 7.29%PRS 36.92
-
CSI 8.59rCSI 6.17%PRS 17.28
-
CSI 8.55rCSI 7.17%PRS 15.22
-
CSI 8.5rCSI 12.98%PRS 12.72
-
CSI 8.37rCSI 18.42%PRS 14.05
-
CSI 8.2rCSI 9.39%PRS 26.11
-
CSI 8.2rCSI 14.91%PRS 48.47
-
CSI 8.1rCSI 32.25%PRS 22.4
-
CSI 8.08rCSI 9.33%PRS 11.17
-
CSI 8.04rCSI 10.98%PRS 14.11
-
CSI 8.01rCSI 6.33%PRS 8.74
-
CSI 7.91rCSI 7.77%PRS 20.05
-
CSI 7.89rCSI 8.64%PRS 14.55
-
CSI 7.77rCSI 85.13%PRS 22.98
-
CSI 7.56rCSI 17.3%PRS 12.28
-
CSI 7.52rCSI 32.49%PRS 24.36
-
CSI 7.5rCSI 13.48%PRS 10.61
-
CSI 7.47rCSI 7.38%PRS 47.43
-
CSI 7.2rCSI 15.95%PRS 11.84
-
CSI 7.03rCSI 9.74%PRS 18.32
-
CSI 6.88rCSI 4.79%PRS 18.08
-
CSI 6.82rCSI 7.15%PRS 13.6
-
CSI 6.81rCSI 19.43%PRS 21.97
-
CSI 6.7rCSI 15.72%PRS 19.28
-
CSI 6.63rCSI 12.64%PRS 20.27
-
CSI 6.63rCSI 17.29%PRS 20.28
-
CSI 6.59rCSI 19.44%PRS 15.53
-
CSI 6.58rCSI 6.77%PRS 20.75
-
CSI 6.58rCSI 4.59%PRS 13.34
-
CSI 6.52rCSI 6.99%PRS 11.72
-
CSI 6.45rCSI 5.65%PRS 16.85
-
CSI 6.38rCSI 4.85%PRS 16.64
-
CSI 6.36rCSI 69.15%PRS 24.49
-
CSI 6.35rCSI 16.08%PRS 15.79
-
CSI 6.2rCSI 9.46%PRS 22.13
-
CSI 6.17rCSI 7.68%PRS 17.93
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CSI 6.16rCSI 8.42%PRS 14.44
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CSI 6.12rCSI 11.56%PRS 15.79
-
CSI 6.11rCSI 60.11%PRS 37.23
-
CSI 6.08rCSI 7.29%PRS 21.81
-
CSI 6.06rCSI 17.37%PRS 18.47
-
CSI 5.99rCSI 12.31%PRS 12.96
-
CSI 5.99rCSI 5.53%PRS 23.16
-
CSI 5.97rCSI 9.67%PRS 12.98
-
CSI 5.92rCSI 36.58%PRS 41.15
-
CSI 5.92rCSI 7.6%PRS 12.37
-
CSI 5.89rCSI 38.65%PRS 32.81
-
CSI -8.6rCSI -27.8%PRS 15.6%
-
CSI -1.9rCSI -3.6%PRS 27.6%
-
CSI -0.9rCSI -1.9%PRS 25.7%
-
CSI 0.0rCSI 0.0%PRS 16.8%
-
CSI 0.1rCSI 0.1%PRS 7.8%
-
CSI 0.1rCSI 3.6%PRS 55.3%
-
CSI 0.2rCSI 1.0%PRS 28.3%
-
CSI 0.2rCSI 3.5%PRS 60.7%
-
CSI 0.2rCSI 1.3%PRS 42.4%
-
CSI 0.4rCSI 2.1%PRS 31.4%
-
CSI 0.4rCSI 1.2%PRS 21.0%
-
CSI 0.5rCSI 4.5%PRS 51.2%
-
CSI 0.5rCSI 2.7%PRS 18.6%
-
CSI 0.5rCSI 0.8%PRS 11.9%
-
CSI 0.5rCSI 3.0%PRS 39.8%
-
CSI 0.5rCSI 1.4%PRS 11.9%
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CSI 0.5rCSI 1.9%PRS 6.9%
-
CSI 0.6rCSI 3.4%PRS 46.7%
-
CSI 0.6rCSI 1.6%PRS 36.8%
-
CSI 0.7rCSI 1.4%PRS 17.0%
-
CSI 0.7rCSI 3.4%PRS 17.3%
-
CSI 0.7rCSI 3.1%PRS 55.6%
-
CSI 0.7rCSI 7.8%PRS 48.1%
-
CSI 0.7rCSI 3.3%PRS 43.7%
-
CSI 0.8rCSI 1.1%PRS 26.2%
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CSI 0.8rCSI 2.1%PRS 24.9%
-
CSI 0.8rCSI 1.3%PRS 9.8%
-
CSI 0.8rCSI 1.3%PRS 12.5%
-
CSI 0.9rCSI 1.1%PRS 12.6%
-
CSI 0.9rCSI 16.4%PRS 36.2%
-
CSI 1.0rCSI 3.7%PRS 17.8%
-
CSI 1.0rCSI 7.7%PRS 27.6%
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CSI 1.1rCSI 1.8%PRS 7.5%
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CSI 1.1rCSI 3.0%PRS 18.1%
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CSI 1.1rCSI 14.4%PRS 40.8%
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CSI 1.1rCSI 6.0%PRS 23.8%
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CSI 1.1rCSI 3.2%PRS 24.7%
-
CSI 1.1rCSI 1.8%PRS 10.9%
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CSI 1.2rCSI 2.5%PRS 9.2%
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CSI 1.2rCSI 2.2%PRS 19.5%
-
CSI 1.2rCSI 1.0%PRS 15.7%
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CSI 1.2rCSI 1.5%PRS 22.0%
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CSI 1.2rCSI 3.0%PRS 19.0%
-
CSI 1.2rCSI 8.5%PRS 24.9%
-
CSI 1.3rCSI 2.1%PRS 9.8%
-
CSI 1.3rCSI 3.9%PRS 19.8%
-
CSI 1.3rCSI 3.8%PRS 14.4%
-
CSI 1.3rCSI 1.2%PRS 26.3%
-
CSI 1.3rCSI 10.6%PRS 56.1%
-
CSI 1.4rCSI 6.0%PRS 12.4%
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CSI 1.4rCSI 2.6%PRS 25.1%
-
CSI 1.4rCSI 14.1%PRS 44.4%
-
CSI 1.5rCSI 3.9%PRS 11.7%
-
CSI 1.6rCSI 6.0%PRS 26.3%
-
CSI 1.7rCSI 1.3%PRS 21.3%
-
CSI 1.8rCSI 2.7%PRS 14.8%
-
CSI 1.8rCSI 1.4%PRS 22.5%
-
CSI 1.8rCSI 2.5%PRS 30.6%
-
CSI 1.9rCSI 4.1%PRS 19.5%
-
CSI 1.9rCSI 2.3%PRS 11.2%
-
CSI 1.9rCSI 5.9%PRS 8.0%
-
CSI 1.9rCSI 3.0%PRS 14.6%
-
CSI 2.0rCSI 8.7%PRS 49.7%
-
CSI 2.0rCSI 46.0%PRS 22.7%
-
CSI 2.0rCSI 2.7%PRS 16.9%
-
CSI 2.1rCSI 11.0%PRS 22.6%
-
CSI 2.1rCSI 3.0%PRS 11.8%
-
CSI 2.1rCSI 3.8%PRS 7.4%
-
CSI 2.2rCSI 2.4%PRS 20.4%
-
CSI 2.2rCSI 12.3%PRS 19.6%
-
CSI 2.2rCSI 5.3%PRS 16.1%
-
CSI 2.2rCSI 5.5%PRS 11.8%
-
CSI 2.3rCSI 12.0%PRS 45.8%
-
CSI 2.3rCSI 5.5%PRS 23.1%
-
CSI 2.3rCSI 69.0%PRS 29.3%
-
CSI 2.4rCSI 1.8%PRS 18.8%
-
CSI 2.5rCSI 4.4%PRS 21.6%
-
CSI 2.5rCSI 3.6%PRS 9.9%
-
CSI 2.5rCSI 3.2%PRS 19.4%
-
CSI 2.6rCSI 3.9%PRS 15.5%
-
CSI 2.6rCSI 3.1%PRS 14.9%
-
CSI 2.6rCSI 6.9%PRS 15.2%
-
CSI 2.6rCSI 4.7%PRS 11.9%
-
CSI 2.7rCSI 9.9%PRS 10.8%
-
CSI 2.7rCSI 4.2%PRS 13.9%
-
CSI 2.7rCSI 2.1%PRS 11.5%
-
CSI 2.7rCSI 4.8%PRS 12.6%
-
CSI 2.7rCSI 6.1%PRS 7.8%
-
CSI 2.7rCSI 8.2%PRS 31.5%
-
CSI 2.8rCSI 1.6%PRS 17.5%
-
CSI 2.8rCSI 21.2%PRS 23.3%
-
CSI 2.9rCSI 8.4%PRS 22.8%
-
CSI 3.0rCSI 4.3%PRS 17.7%
-
CSI 3.0rCSI 10.6%PRS 39.4%
-
CSI 3.0rCSI 4.1%PRS 11.4%
-
CSI 3.0rCSI 15.4%PRS 49.9%
-
CSI 3.1rCSI 6.9%PRS 14.4%
-
CSI 3.1rCSI 3.9%PRS 7.0%
-
CSI 3.2rCSI 2.7%PRS 20.5%
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CSI 3.2rCSI 6.4%PRS 9.4%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 29130662
Symbol: AK1A1_HUMAN
Name: Aldo-keto reductase family 1 member A1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2498333
Title: The aldo-keto reductase superfamily. cDNAs and deduced amino acid sequences of human aldehyde and aldose reductases.
PubMed ID: 2498333
PubMed ID: 10393438
Title: The structural organization of the human aldehyde reductase gene, AKR1A1, and mapping to chromosome 1p33-->p32.
PubMed ID: 10393438
DOI: 10.1159/000015265
PubMed ID: 10486210
Title: Characterization of the human aldehyde reductase gene and promoter.
PubMed ID: 10486210
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 3615425
Title: Primary structure of aldehyde reductase from human liver.
PubMed ID: 3615425
PubMed ID: 7669785
Title: Mechanism of human aldehyde reductase: characterization of the active site pocket.
PubMed ID: 7669785
DOI: 10.1021/bi00035a036
PubMed ID: 10510318
Title: Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members.
PubMed ID: 10510318
DOI: 10.1042/bj3430487
PubMed ID: 11306097
Title: Metabolic activation of polycyclic aromatic hydrocarbon trans-dihydrodiols by ubiquitously expressed aldehyde reductase (AKR1A1).
PubMed ID: 11306097
PubMed ID: 18276838
Title: Two allelic variants of aldo-keto reductase 1A1 exhibit reduced in vitro metabolism of daunorubicin.
PubMed ID: 18276838
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 30538128
Title: Molecular recognition of S-nitrosothiol substrate by its cognate protein denitrosylase.
PubMed ID: 30538128
PubMed ID: 31649033
Title: AKR1A1 is a novel mammalian S-nitroso-glutathione reductase.
PubMed ID: 31649033
PubMed ID: 15299353
Title: Structures of human and porcine aldehyde reductase: an enzyme implicated in diabetic complications.
PubMed ID: 15299353
Sequence Information:
- Length: 325
- Mass: 36573
- Checksum: F6B27517EB754E37
- Sequence:
MAASCVLLHT GQKMPLIGLG TWKSEPGQVK AAVKYALSVG YRHIDCAAIY GNEPEIGEAL KEDVGPGKAV PREELFVTSK LWNTKHHPED VEPALRKTLA DLQLEYLDLY LMHWPYAFER GDNPFPKNAD GTICYDSTHY KETWKALEAL VAKGLVQALG LSNFNSRQID DILSVASVRP AVLQVECHPY LAQNELIAHC QARGLEVTAY SPLGSSDRAW RDPDEPVLLE EPVVLALAEK YGRSPAQILL RWQVQRKVIC IPKSITPSRI LQNIKVFDFT FSPEEMKQLN ALNKNWRYIV PMLTVDGKRV PRDAGHPLYP FNDPY