AKR1A1 | ENSG00000117448 | NCBI 10327

Details for: AKR1A1

Gene ID: 10327

Symbol: AKR1A1

Ensembl ID: ENSG00000117448

Description: aldo-keto reductase family 1 member A1

Associated with

Biological oxidations
(R-HSA-211859)
Formation of xylulose-5-phosphate
(R-HSA-5661270)
Glutathione conjugation
(R-HSA-156590)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Phase ii - conjugation of compounds
(R-HSA-156580)
Aldehyde catabolic process
(GO:0046185)
Alditol:nadp+ 1-oxidoreductase activity
(GO:0004032)
Aldo-keto reductase (nadp) activity
(GO:0004033)
Allyl-alcohol dehydrogenase activity
(GO:0047655)
Apical plasma membrane
(GO:0016324)
Cellular detoxification of aldehyde
(GO:0110095)
Cytosol
(GO:0005829)
D-glucuronate catabolic process
(GO:0042840)
Daunorubicin metabolic process
(GO:0044597)
Doxorubicin metabolic process
(GO:0044598)
Extracellular exosome
(GO:0070062)
Extracellular space
(GO:0005615)
Glucuronate catabolic process to xylulose 5-phosphate
(GO:0019640)
Glucuronolactone reductase activity
(GO:0047941)
Glutathione derivative biosynthetic process
(GO:1901687)
Glycerol dehydrogenase [nadp+] activity
(GO:0047956)
L-ascorbic acid biosynthetic process
(GO:0019853)
L-glucuronate reductase activity
(GO:0047939)
Lipid metabolic process
(GO:0006629)
Methylglyoxal reductase (nadph-dependent, acetol producing)
(GO:1990002)
Nad-retinol dehydrogenase activity
(GO:0004745)
Negative regulation of apoptotic process
(GO:0043066)
Protein binding
(GO:0005515)
Synapse
(GO:0045202)

Other Information

Proteins

Aldo-keto reductase family 1 member A1

Genular Protein ID: 29130662

Symbol: AK1A1_HUMAN

Name: Aldo-keto reductase family 1 member A1

UniProtKB Accession Codes:

P14550 A8KAL8 D3DQ04 Q6IAZ4

Database IDs:

Citations:

PubMed ID: 2498333

Title: The aldo-keto reductase superfamily. cDNAs and deduced amino acid sequences of human aldehyde and aldose reductases.

PubMed ID: 2498333

DOI: 10.1016/s0021-9258(18)60566-6

PubMed ID: 10393438

Title: The structural organization of the human aldehyde reductase gene, AKR1A1, and mapping to chromosome 1p33-->p32.

PubMed ID: 10393438

DOI: 10.1159/000015265

PubMed ID: 10486210

Title: Characterization of the human aldehyde reductase gene and promoter.

PubMed ID: 10486210

DOI: 10.1006/geno.1999.5915

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3615425

Title: Primary structure of aldehyde reductase from human liver.

PubMed ID: 3615425

PubMed ID: 7669785

Title: Mechanism of human aldehyde reductase: characterization of the active site pocket.

PubMed ID: 7669785

DOI: 10.1021/bi00035a036

PubMed ID: 10510318

Title: Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members.

PubMed ID: 10510318

DOI: 10.1042/bj3430487

PubMed ID: 11306097

Title: Metabolic activation of polycyclic aromatic hydrocarbon trans-dihydrodiols by ubiquitously expressed aldehyde reductase (AKR1A1).

PubMed ID: 11306097

DOI: 10.1016/s0009-2797(00)00237-4

PubMed ID: 18276838

Title: Two allelic variants of aldo-keto reductase 1A1 exhibit reduced in vitro metabolism of daunorubicin.

PubMed ID: 18276838

DOI: 10.1124/dmd.107.018895

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 15299353

Title: Structures of human and porcine aldehyde reductase: an enzyme implicated in diabetic complications.

PubMed ID: 15299353

DOI: 10.1107/s0907444994005275

Sequence Information:

Length: 325
Mass: 36573
Checksum: F6B27517EB754E37
Sequence:

MAASCVLLHT GQKMPLIGLG TWKSEPGQVK AAVKYALSVG YRHIDCAAIY GNEPEIGEAL 
KEDVGPGKAV PREELFVTSK LWNTKHHPED VEPALRKTLA DLQLEYLDLY LMHWPYAFER 
GDNPFPKNAD GTICYDSTHY KETWKALEAL VAKGLVQALG LSNFNSRQID DILSVASVRP 
AVLQVECHPY LAQNELIAHC QARGLEVTAY SPLGSSDRAW RDPDEPVLLE EPVVLALAEK 
YGRSPAQILL RWQVQRKVIC IPKSITPSRI LQNIKVFDFT FSPEEMKQLN ALNKNWRYIV 
PMLTVDGKRV PRDAGHPLYP FNDPY

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: AKR1A1

Associated with

Other Information

The aldo-keto reductase superfamily. cDNAs and deduced amino acid sequences of human aldehyde and aldose reductases. PubMed ID: 2498333

The structural organization of the human aldehyde reductase gene, AKR1A1, and mapping to chromosome 1p33--&gt;p32. PubMed ID: 10393438

Characterization of the human aldehyde reductase gene and promoter. PubMed ID: 10486210

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Primary structure of aldehyde reductase from human liver. PubMed ID: 3615425

Mechanism of human aldehyde reductase: characterization of the active site pocket. PubMed ID: 7669785

Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members. PubMed ID: 10510318

Metabolic activation of polycyclic aromatic hydrocarbon trans-dihydrodiols by ubiquitously expressed aldehyde reductase (AKR1A1). PubMed ID: 11306097

Two allelic variants of aldo-keto reductase 1A1 exhibit reduced in vitro metabolism of daunorubicin. PubMed ID: 18276838

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Structures of human and porcine aldehyde reductase: an enzyme implicated in diabetic complications. PubMed ID: 15299353