Details for: TMEM160

Gene ID: 54958

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: TMEM160

Ensembl ID: ENSG00000130748

Description: transmembrane protein 160

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • pancreatic A cell CL0000171
    CSI 39.11
    rCSI 40.97%
    PRS 38.42
  • peripheral nervous system neuron CL2000032
    CSI 32.59
    rCSI 44.41%
    PRS 31.25
  • granulocyte monocyte progenitor cell CL0000557
    CSI 25.56
    rCSI 22.13%
    PRS 39.91
  • pancreatic D cell CL0000173
    CSI 24.8
    rCSI 24.39%
    PRS 38.52
  • common myeloid progenitor CL0000049
    CSI 24.65
    rCSI 19.93%
    PRS 36.73
  • transit amplifying cell of colon CL0009011
    CSI 23.32
    rCSI 27.39%
    PRS 40.03
  • IgG plasma cell CL0000985
    CSI 22.5
    rCSI 26.95%
    PRS 55.11
  • pancreatic ductal cell CL0002079
    CSI 21.35
    rCSI 41.51%
    PRS 37.83
  • retinal ganglion cell CL0000740
    CSI 21.09
    rCSI 46.58%
    PRS 26.8
  • common dendritic progenitor CL0001029
    CSI 20.34
    rCSI 25.53%
    PRS 45.17
  • plasmablast CL0000980
    CSI 17.76
    rCSI 13.97%
    PRS 42.12
  • pancreatic acinar cell CL0002064
    CSI 16.05
    rCSI 21.33%
    PRS 40.19
  • stem cell CL0000034
    CSI 14.72
    rCSI 14.2%
    PRS 28.23
  • promonocyte CL0000559
    CSI 12.95
    rCSI 22.19%
    PRS 45.58
  • pulmonary alveolar type 2 cell CL0002063
    CSI 12.19
    rCSI 18.9%
    PRS 46.93
  • respiratory suprabasal cell CL4033048
    CSI 12.13
    rCSI 15.56%
    PRS 40.85
  • pancreatic PP cell CL0002275
    CSI 11.07
    rCSI 44.05%
    PRS 52.22
  • pulmonary artery endothelial cell CL1001568
    CSI 10.67
    rCSI 14.52%
    PRS 49.02
  • immature B cell CL0000816
    CSI 10.37
    rCSI 7.7%
    PRS 48.8
  • fallopian tube secretory epithelial cell CL4030006
    CSI 10.23
    rCSI 9.85%
    PRS 37.05
  • type B pancreatic cell CL0000169
    CSI 9.85
    rCSI 21.8%
    PRS 33.74
  • promyelocyte CL0000836
    CSI 9.13
    rCSI 13.16%
    PRS 46.25
  • group 3 innate lymphoid cell CL0001071
    CSI 8.79
    rCSI 6.61%
    PRS 39.01
  • nasal mucosa goblet cell CL0002480
    CSI 8.59
    rCSI 9.96%
    PRS 47.24
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 8.54
    rCSI 14.33%
    PRS 23.33
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 8.22
    rCSI 7.43%
    PRS 33.4
  • retinal cone cell CL0000573
    CSI 7.89
    rCSI 12.69%
    PRS 28.56
  • multi-ciliated epithelial cell CL0005012
    CSI 7.29
    rCSI 7.28%
    PRS 31.34
  • alveolar adventitial fibroblast CL4028006
    CSI 6.96
    rCSI 10.99%
    PRS 37.08
  • lung pericyte CL0009089
    CSI 6.9
    rCSI 18.21%
    PRS 42.86
  • effector CD4-positive, alpha-beta T cell CL0001044
    CSI 6.7
    rCSI 19.21%
    PRS 52.32
  • innate lymphoid cell CL0001065
    CSI 6.38
    rCSI 13.18%
    PRS 44.83
  • CD8-positive, alpha-beta memory T cell CL0000909
    CSI 6.33
    rCSI 6.61%
    PRS 68.75
  • CD16-positive, CD56-dim natural killer cell, human CL0000939
    CSI 6.3
    rCSI 4.2%
    PRS 63.38
  • foveolar cell of stomach CL0002179
    CSI 6.12
    rCSI 13.02%
    PRS 51.34
  • Cajal-Retzius cell CL0000695
    CSI 6.11
    rCSI 47.86%
    PRS 54.96
  • central memory CD4-positive, alpha-beta T cell CL0000904
    CSI 6.01
    rCSI 3.55%
    PRS 49.57
  • choroid plexus epithelial cell CL0000706
    CSI 5.98
    rCSI 9.79%
    PRS 28.59
  • mesenchymal cell CL0008019
    CSI 5.83
    rCSI 14.8%
    PRS 33.8
  • natural T-regulatory cell CL0000903
    CSI 5.75
    rCSI 10.89%
    PRS 71.64
  • lung ciliated cell CL1000271
    CSI 5.65
    rCSI 6.54%
    PRS 27.89
  • vascular associated smooth muscle cell CL0000359
    CSI 5.51
    rCSI 17.86%
    PRS 39.94
  • respiratory basal cell CL0002633
    CSI 5.28
    rCSI 5.47%
    PRS 41.82
  • activated type II NK T cell CL0000931
    CSI 5.24
    rCSI 5.9%
    PRS 51.94
  • effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062
    CSI 5.21
    rCSI 26.16%
    PRS 46.17
  • double negative thymocyte CL0002489
    CSI 5.12
    rCSI 3.56%
    PRS 43.66
  • mononuclear phagocyte CL0000113
    CSI 5.1
    rCSI 11.24%
    PRS 40.27
  • naive T cell CL0000898
    CSI 5.02
    rCSI 3.5%
    PRS 48.24
  • naive thymus-derived CD8-positive, alpha-beta T cell CL0000900
    CSI 4.86
    rCSI 3.41%
    PRS 61.44
  • luminal epithelial cell of mammary gland CL0002326
    CSI 4.81
    rCSI 8.75%
    PRS 52.09
  • erythrocyte CL0000232
    CSI 4.76
    rCSI 10.8%
    PRS 42.43
  • pancreatic epsilon cell CL0005019
    CSI 4.68
    rCSI 21.81%
    PRS 60.96
  • effector memory CD8-positive, alpha-beta T cell CL0000913
    CSI 4.6
    rCSI 4.19%
    PRS 50.89
  • inflammatory macrophage CL0000863
    CSI 4.6
    rCSI 7.85%
    PRS 62.72
  • precursor B cell CL0000817
    CSI 4.54
    rCSI 3.98%
    PRS 45.64
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 4.44
    rCSI 26.17%
    PRS 24.5
  • alveolar macrophage CL0000583
    CSI 4.37
    rCSI 7.19%
    PRS 41.27
  • ciliated cell CL0000064
    CSI 4.24
    rCSI 6.87%
    PRS 35.51
  • hematopoietic stem cell CL0000037
    CSI 4.14
    rCSI 2.75%
    PRS 40.56
  • type L enteroendocrine cell CL0002279
    CSI 3.92
    rCSI 7.36%
    PRS 57.15
  • double-positive, alpha-beta thymocyte CL0000809
    CSI 3.89
    rCSI 3.97%
    PRS 48.4
  • vein endothelial cell of respiratory system CL4033008
    CSI 3.83
    rCSI 26.28%
    PRS 56.4
  • mature NK T cell CL0000814
    CSI 3.77
    rCSI 4.83%
    PRS 72.92
  • conventional dendritic cell CL0000990
    CSI 3.77
    rCSI 3.14%
    PRS 60.83
  • naive thymus-derived CD4-positive, alpha-beta T cell CL0000895
    CSI 3.75
    rCSI 4.72%
    PRS 78.52
  • goblet cell CL0000160
    CSI 3.74
    rCSI 3.54%
    PRS 37.55
  • skin fibroblast CL0002620
    CSI 3.72
    rCSI 3.2%
    PRS 46.09
  • common lymphoid progenitor CL0000051
    CSI 3.71
    rCSI 4.96%
    PRS 58.78
  • CD16-negative, CD56-bright natural killer cell, human CL0000938
    CSI 3.65
    rCSI 2.73%
    PRS 70.3
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 3.64
    rCSI 4.52%
    PRS 22.02
  • cerebral cortex GABAergic interneuron CL0010011
    CSI 3.6
    rCSI 10.62%
    PRS 40.7
  • pulmonary capillary endothelial cell CL4028001
    CSI 3.59
    rCSI 6.84%
    PRS 52.74
  • acinar cell CL0000622
    CSI 3.41
    rCSI 5%
    PRS 46.43
  • extravillous trophoblast CL0008036
    CSI 3.32
    rCSI 4.11%
    PRS 32.67
  • perivascular cell CL4033054
    CSI 3.31
    rCSI 4.53%
    PRS 40.5
  • hematopoietic precursor cell CL0008001
    CSI 3.3
    rCSI 3.4%
    PRS 53.11
  • epithelial cell of lower respiratory tract CL0002632
    CSI 3.29
    rCSI 2.55%
    PRS 36.15
  • progenitor cell CL0011026
    CSI 3.27
    rCSI 6.95%
    PRS 43.1
  • basal cell CL0000646
    CSI 3.25
    rCSI 4.35%
    PRS 38.11
  • CD4-positive, alpha-beta thymocyte CL0000810
    CSI 3.2
    rCSI 2.56%
    PRS 57.22
  • kidney distal convoluted tubule epithelial cell CL1000849
    CSI 3.15
    rCSI 33.37%
    PRS 39.66
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 3.13
    rCSI 3.78%
    PRS 42.98
  • non-classical monocyte CL0000875
    CSI 3.07
    rCSI 4.93%
    PRS 66.59
  • CD14-positive monocyte CL0001054
    CSI 3.04
    rCSI 3.79%
    PRS 47.34
  • secretory cell CL0000151
    CSI 3.03
    rCSI 3.16%
    PRS 36.95
  • myofibroblast cell CL0000186
    CSI 2.95
    rCSI 4.08%
    PRS 42.73
  • CD4-positive, alpha-beta memory T cell CL0000897
    CSI 2.89
    rCSI 2.08%
    PRS 47.99
  • elicited macrophage CL0000861
    CSI 2.86
    rCSI 2.63%
    PRS 42.69
  • activated CD8-positive, alpha-beta T cell CL0000906
    CSI 2.84
    rCSI 2.79%
    PRS 66.15
  • lung secretory cell CL1000272
    CSI 2.79
    rCSI 6.9%
    PRS 34.57
  • mature alpha-beta T cell CL0000791
    CSI 2.76
    rCSI 10%
    PRS 54.53
  • radial glial cell CL0000681
    CSI 2.71
    rCSI 3.77%
    PRS 36.32
  • ON-bipolar cell CL0000749
    CSI 2.66
    rCSI 3.96%
    PRS 39.6
  • epithelial cell CL0000066
    CSI 2.65
    rCSI 4.08%
    PRS 40.87
  • CD4-positive, alpha-beta cytotoxic T cell CL0000934
    CSI 2.65
    rCSI 3.64%
    PRS 56.96
  • colon epithelial cell CL0011108
    CSI 2.64
    rCSI 2.77%
    PRS 34.01
  • T follicular helper cell CL0002038
    CSI 2.64
    rCSI 1.98%
    PRS 50.69
  • monocyte CL0000576
    CSI 2.63
    rCSI 4.75%
    PRS 61.48
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 2.58
    rCSI 3.31%
    PRS 34.65
  • interneuron CL0000099
    CSI 2.58
    rCSI 5.18%
    PRS 27.78
  • cytotoxic T cell CL0000910
    CSI 0.2
    rCSI 0.9%
    PRS 48.7%
  • peptic cell CL0000155
    CSI 0.2
    rCSI 1.9%
    PRS 65.3%
  • group 2 innate lymphoid cell CL0001069
    CSI 0.3
    rCSI 1.5%
    PRS 74.4%
  • kidney connecting tubule epithelial cell CL1000768
    CSI 0.3
    rCSI 0.7%
    PRS 28.6%
  • paneth cell of colon CL0009009
    CSI 0.3
    rCSI 2.9%
    PRS 64.4%
  • respiratory goblet cell CL0002370
    CSI 0.3
    rCSI 3.3%
    PRS 57.5%
  • IgM plasma cell CL0000986
    CSI 0.3
    rCSI 1.5%
    PRS 81.0%
  • endothelial cell of placenta CL0009092
    CSI 0.3
    rCSI 1.7%
    PRS 46.9%
  • intestinal crypt stem cell of colon CL0009043
    CSI 0.4
    rCSI 2.9%
    PRS 57.0%
  • epithelial cell of nephron CL1000449
    CSI 0.4
    rCSI 4.0%
    PRS 80.1%
  • podocyte CL0000653
    CSI 0.4
    rCSI 1.9%
    PRS 35.0%
  • erythroid progenitor cell CL0000038
    CSI 0.5
    rCSI 2.6%
    PRS 47.3%
  • P/D1 enteroendocrine cell CL0002268
    CSI 0.5
    rCSI 2.7%
    PRS 61.0%
  • eosinophil CL0000771
    CSI 0.5
    rCSI 3.3%
    PRS 68.5%
  • megakaryocyte CL0000556
    CSI 0.5
    rCSI 2.3%
    PRS 52.8%
  • CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell CL0000915
    CSI 0.5
    rCSI 2.5%
    PRS 74.0%
  • CD14-positive, CD16-negative classical monocyte CL0002057
    CSI 0.6
    rCSI 3.3%
    PRS 62.5%
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 0.6
    rCSI 1.4%
    PRS 35.6%
  • basal cell of epithelium of trachea CL1000348
    CSI 0.6
    rCSI 4.3%
    PRS 64.0%
  • type EC enteroendocrine cell CL0000577
    CSI 0.7
    rCSI 2.3%
    PRS 50.4%
  • Langerhans cell CL0000453
    CSI 0.7
    rCSI 1.0%
    PRS 53.8%
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 0.7
    rCSI 1.6%
    PRS 22.7%
  • enterocyte of epithelium of large intestine CL0002071
    CSI 0.7
    rCSI 3.6%
    PRS 52.3%
  • acinar cell of salivary gland CL0002623
    CSI 0.7
    rCSI 16.3%
    PRS 59.4%
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 0.7
    rCSI 2.0%
    PRS 45.1%
  • microcirculation associated smooth muscle cell CL0008035
    CSI 0.8
    rCSI 2.2%
    PRS 39.1%
  • dendritic cell, human CL0001056
    CSI 0.8
    rCSI 1.2%
    PRS 42.5%
  • kidney epithelial cell CL0002518
    CSI 0.8
    rCSI 1.5%
    PRS 60.0%
  • enteric neuron CL0007011
    CSI 0.8
    rCSI 12.1%
    PRS 60.5%
  • neural progenitor cell CL0011020
    CSI 0.8
    rCSI 3.7%
    PRS 31.4%
  • BEST4+ enteroycte CL4030026
    CSI 0.9
    rCSI 1.1%
    PRS 38.8%
  • colon goblet cell CL0009039
    CSI 0.9
    rCSI 2.0%
    PRS 48.9%
  • helper T cell CL0000912
    CSI 0.9
    rCSI 1.3%
    PRS 46.1%
  • mammary gland epithelial cell CL0002327
    CSI 0.9
    rCSI 3.1%
    PRS 52.5%
  • L6b glutamatergic cortical neuron CL4023038
    CSI 0.9
    rCSI 2.8%
    PRS 24.3%
  • bronchial goblet cell CL1000312
    CSI 0.9
    rCSI 3.7%
    PRS 58.8%
  • transitional stage B cell CL0000818
    CSI 0.9
    rCSI 3.1%
    PRS 69.8%
  • retinal bipolar neuron CL0000748
    CSI 1.0
    rCSI 1.8%
    PRS 27.8%
  • enteroendocrine cell of colon CL0009042
    CSI 1.0
    rCSI 4.8%
    PRS 64.5%
  • hematopoietic multipotent progenitor cell CL0000837
    CSI 1.0
    rCSI 2.5%
    PRS 52.8%
  • CD8-positive, alpha-beta cytotoxic T cell CL0000794
    CSI 1.0
    rCSI 1.2%
    PRS 55.7%
  • VIP GABAergic cortical interneuron CL4023016
    CSI 1.1
    rCSI 1.3%
    PRS 23.3%
  • transit amplifying cell CL0009010
    CSI 1.1
    rCSI 1.6%
    PRS 52.7%
  • intermediate monocyte CL0002393
    CSI 1.1
    rCSI 1.6%
    PRS 37.6%
  • intestinal tuft cell CL0019032
    CSI 1.1
    rCSI 1.6%
    PRS 40.7%
  • myelocyte CL0002193
    CSI 1.1
    rCSI 7.2%
    PRS 72.1%
  • retina horizontal cell CL0000745
    CSI 1.1
    rCSI 1.7%
    PRS 33.7%
  • conjunctival epithelial cell CL1000432
    CSI 1.1
    rCSI 1.7%
    PRS 36.7%
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 1.2
    rCSI 2.0%
    PRS 22.5%
  • T-helper 17 cell CL0000899
    CSI 1.2
    rCSI 1.0%
    PRS 57.4%
  • mucous neck cell CL0000651
    CSI 1.2
    rCSI 1.8%
    PRS 50.1%
  • colonocyte CL1000347
    CSI 1.2
    rCSI 1.8%
    PRS 44.4%
  • germinal center B cell CL0000844
    CSI 1.3
    rCSI 3.7%
    PRS 60.6%
  • neural cell CL0002319
    CSI 1.3
    rCSI 4.7%
    PRS 33.8%
  • intraepithelial lymphocyte CL0002496
    CSI 1.3
    rCSI 3.4%
    PRS 77.5%
  • muscle cell CL0000187
    CSI 1.3
    rCSI 2.6%
    PRS 59.0%
  • effector memory CD4-positive, alpha-beta T cell CL0000905
    CSI 1.3
    rCSI 1.7%
    PRS 64.8%
  • placental villous trophoblast CL2000060
    CSI 1.3
    rCSI 2.0%
    PRS 34.5%
  • rod bipolar cell CL0000751
    CSI 1.3
    rCSI 2.3%
    PRS 30.8%
  • CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920
    CSI 1.3
    rCSI 2.6%
    PRS 53.9%
  • large pre-B-II cell CL0000957
    CSI 1.3
    rCSI 3.7%
    PRS 51.4%
  • squamous epithelial cell CL0000076
    CSI 1.3
    rCSI 3.1%
    PRS 42.2%
  • mesodermal cell CL0000222
    CSI 1.3
    rCSI 1.6%
    PRS 34.8%
  • tracheobronchial smooth muscle cell CL0019019
    CSI 1.3
    rCSI 2.3%
    PRS 44.7%
  • cerebellar granule cell CL0001031
    CSI 1.3
    rCSI 2.0%
    PRS 33.5%
  • T-helper 1 cell CL0000545
    CSI 1.3
    rCSI 2.4%
    PRS 64.4%
  • pulmonary ionocyte CL0017000
    CSI 1.3
    rCSI 1.6%
    PRS 43.4%
  • Kupffer cell CL0000091
    CSI 1.4
    rCSI 3.1%
    PRS 35.9%
  • ionocyte CL0005006
    CSI 1.4
    rCSI 1.5%
    PRS 34.1%
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 1.4
    rCSI 5.2%
    PRS 22.4%
  • CD8-positive, alpha-beta thymocyte CL0000811
    CSI 1.5
    rCSI 2.3%
    PRS 63.6%
  • bronchus fibroblast of lung CL2000093
    CSI 1.5
    rCSI 1.2%
    PRS 37.2%
  • memory T cell CL0000813
    CSI 1.5
    rCSI 2.8%
    PRS 66.3%
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 1.5
    rCSI 3.8%
    PRS 33.4%
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 1.5
    rCSI 4.6%
    PRS 26.3%
  • keratinocyte CL0000312
    CSI 1.5
    rCSI 1.2%
    PRS 41.4%
  • fraction A pre-pro B cell CL0002045
    CSI 1.5
    rCSI 1.7%
    PRS 59.4%
  • blood vessel endothelial cell CL0000071
    CSI 1.6
    rCSI 3.3%
    PRS 35.2%
  • retinal pigment epithelial cell CL0002586
    CSI 1.6
    rCSI 3.2%
    PRS 36.4%
  • alternatively activated macrophage CL0000890
    CSI 1.6
    rCSI 2.0%
    PRS 49.4%
  • OFF-bipolar cell CL0000750
    CSI 1.6
    rCSI 2.2%
    PRS 47.2%
  • respiratory hillock cell CL4030023
    CSI 1.6
    rCSI 2.9%
    PRS 52.4%
  • glioblast CL0000030
    CSI 1.7
    rCSI 2.6%
    PRS 31.3%
  • pro-B cell CL0000826
    CSI 1.7
    rCSI 1.4%
    PRS 37.1%
  • sst GABAergic cortical interneuron CL4023017
    CSI 1.7
    rCSI 2.2%
    PRS 24.1%
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 1.7
    rCSI 2.4%
    PRS 34.0%
  • astrocyte of the cerebral cortex CL0002605
    CSI 1.7
    rCSI 3.8%
    PRS 23.8%
  • transit amplifying cell of small intestine CL0009012
    CSI 1.7
    rCSI 7.6%
    PRS 56.4%
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 1.7
    rCSI 2.0%
    PRS 31.8%
  • epithelial cell of lung CL0000082
    CSI 1.8
    rCSI 1.5%
    PRS 34.8%
  • class switched memory B cell CL0000972
    CSI 1.8
    rCSI 1.4%
    PRS 54.4%
  • pancreatic stellate cell CL0002410
    CSI 1.9
    rCSI 10.8%
    PRS 47.7%
  • interstitial cell of Cajal CL0002088
    CSI 1.9
    rCSI 2.4%
    PRS 41.0%
  • tracheal goblet cell CL1000329
    CSI 1.9
    rCSI 4.1%
    PRS 56.7%
  • deuterosomal cell CL4033044
    CSI 1.9
    rCSI 6.4%
    PRS 47.5%
  • inhibitory interneuron CL0000498
    CSI 1.9
    rCSI 4.4%
    PRS 30.0%
  • vascular leptomeningeal cell CL4023051
    CSI 1.9
    rCSI 3.3%
    PRS 29.6%
  • myeloid lineage restricted progenitor cell CL0000839
    CSI 1.9
    rCSI 9.8%
    PRS 60.1%
  • CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792
    CSI 1.9
    rCSI 1.9%
    PRS 51.0%
  • epithelial cell of proximal tubule CL0002306
    CSI 1.9
    rCSI 4.7%
    PRS 33.8%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.

Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [TMEM160](/details-gene/54958) is a protein-coding gene that encodes Transmembrane protein 160. Functional annotation and proteomic studies localize the protein to the **mitochondrial inner membrane** ([GO:0005743](https://www.ebi.ac.uk/QuickGO/term/GO:0005743)), where it is predicted to participate in protein binding ([GO:0005515](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)) ([Link](https://pubmed.ncbi.nlm.nih.gov/25944712/)). **Overall** expression data reveal its significance in a diverse set of cell types, with particularly high relevance in metabolically active cells such as [pancreatic A cells](/details-cell/CL0000171), [peripheral nervous system neurons](/details-cell/CL2000032), and hematopoietic progenitors, including [granulocyte monocyte progenitor cells](/details-cell/CL0000557). Recent research has implicated [TMEM160](/details-gene/54958) in the establishment of nerve injury-induced pain behaviors in animal models, suggesting a functional role in the nervous system ([Link](https://doi.org/10.1016/j.celrep.2021.110152)). ## Cellular Roles and Expression Landscape The expression profile of [TMEM160](/details-gene/54958) suggests it plays a fundamental role in several distinct biological systems, likely tied to its mitochondrial function. * **Pancreatic Tissue:** The gene shows a very high cell significance index in endocrine [pancreatic A cells](/details-cell/CL0000171) (CSI: 39.11) and [pancreatic D cells](/details-cell/CL0000173) (CSI: 24.80), as well as in exocrine [pancreatic acinar cells](/details-cell/CL0002064) and [pancreatic ductal cells](/details-cell/CL0002079). This strong expression across multiple pancreatic lineages points towards a potential role in the high-energy processes of hormone and enzyme synthesis and secretion. * **Nervous System:** [TMEM160](/details-gene/54958) is a significant marker in neurons, particularly [peripheral nervous system neurons](/details-cell/CL2000032) (CSI: 32.59) and [retinal ganglion cells](/details-cell/CL0000740) (CSI: 21.09). This is consistent with functional studies demonstrating its contribution to pain behaviors following nerve injury, indicating a possible role in neuronal mitochondrial homeostasis or stress response ([Link](https://doi.org/10.1016/j.celrep.2021.110152)). * **Hematopoiesis:** The gene is highly significant in several hematopoietic progenitor populations, including [granulocyte monocyte progenitor cells](/details-cell/CL0000557), [common myeloid progenitors](/details-cell/CL0000049), and [common dendritic progenitors](/details-cell/CL0001029). This suggests an involvement in the metabolic regulation of early myeloid lineage commitment and differentiation. Its continued significance in terminally differentiated cells like [IgG plasma cells](/details-cell/CL0000985) further implies a role in supporting the bioenergetic demands of antibody production. ## Pathways and Molecular Function Functional annotation localizes [TMEM160](/details-gene/54958) to the [mitochondrion](/details-cell/GO:0005739), specifically the **mitochondrial inner membrane** ([GO:0005743](https://www.ebi.ac.uk/QuickGO/term/GO:0005743)), an assignment supported by N-terminome analysis of the human mitochondrial proteome ([Link](https://pubmed.ncbi.nlm.nih.gov/25944712/)). Its annotated molecular function is **protein binding** ([GO:0005515](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)), suggesting it may function as a component of a larger protein complex within the mitochondrial membrane. This mitochondrial role provides a unifying theme for its diverse expression pattern. The high metabolic activity and energy requirements of neurons for signal transmission, pancreatic islet cells for hormone secretion, and plasma cells for antibody synthesis are all critically dependent on efficient mitochondrial function. Therefore, the role of [TMEM160](/details-gene/54958) may be to support mitochondrial bioenergetics or structural integrity in these high-demand cell types. Its reported involvement in pain signaling may stem from a role in regulating mitochondrial responses to neuronal damage. ## Research Directions The widespread expression of [TMEM160](/details-gene/54958) in metabolically active cells, combined with its mitochondrial localization and link to neuropathic pain, opens several avenues for future investigation. **Proposed Hypotheses:** 1. **Role in Neuropathic Pain:** [TMEM160](/details-gene/54958) regulates mitochondrial calcium homeostasis or bioenergetics in sensory neurons, and its upregulation following nerve injury contributes to the mitochondrial dysfunction that underlies the development of chronic pain. 2. **Role in Pancreatic Islet Function:** [TMEM160](/details-gene/54958) is essential for maintaining mitochondrial integrity and ATP production required for the regulated secretion of glucagon and somatostatin from pancreatic A and D cells, respectively. 3. **Role in Myelopoiesis:** [TMEM160](/details-gene/54958) is involved in the metabolic reprogramming that accompanies the differentiation of myeloid progenitors, potentially by modulating the assembly or activity of respiratory chain complexes. **Experimental Approach:** To test the first hypothesis regarding the role of [TMEM160](/details-gene/54958) in neuropathic pain, a conditional knockout mouse model could be employed. Specifically, deleting [TMEM160](/details-gene/54958) in peripheral sensory neurons (e.g., using an Advillin-Cre or Nav1.8-Cre driver) would allow for a precise dissection of its cell-autonomous function. Following a nerve injury model, such as spared nerve injury (SNI), these mice would be assessed for changes in pain-related behaviors (e.g., mechanical allodynia). Dorsal root ganglia (DRG) from these animals could then be harvested to perform *ex vivo* analyses, including Seahorse assays to measure mitochondrial respiration, live-cell imaging to monitor mitochondrial calcium dynamics, and proteomics to identify potential binding partners of [TMEM160](/details-gene/54958) within the mitochondrial membrane. **Therapeutic Potential:** Given the evidence that [TMEM160](/details-gene/54958) contributes to pain states ([Link](https://doi.org/10.1016/j.celrep.2021.110152)), it represents a potential non-opioid therapeutic target for the management of neuropathic pain. The therapeutic strategy would likely involve **inhibition** of its function. As a mitochondrial inner membrane protein, developing specific small molecule inhibitors could be challenging but offers a novel mechanism of action. Targeting [TMEM160](/details-gene/54958) could potentially mitigate the mitochondrial dysfunction associated with neuronal injury, thereby preventing the transition from acute to chronic pain.

Genular Protein ID: 1735323688

Symbol: TM160_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 34936870

Title: Tmem160 contributes to the establishment of discrete nerve injury-induced pain behaviors in male mice.

PubMed ID: 34936870

DOI: 10.1016/j.celrep.2021.110152

Sequence Information:

  • Length: 188
  • Mass: 19658
  • Checksum: 955BE1A693B46A28
  • Sequence:
  • MGGGWWWARA ARLARLRFRR SLLPPQRPRS GGARGSFAPG HGPRAGASPP PVSELDRADA 
    WLLRKAHETA FLSWFRNGLL ASGIGVISFM QSDMGREAAY GFFLLGGLCV VWGSASYAVG 
    LAALRGPMQL TLGGAAVGAG AVLAASLLWA CAVGLYMGQL ELDVELVPED DGTASAEGPD 
    EAGRPPPE