Details for: PAXX
Gene ID: 286257
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PAXX
Ensembl ID: ENSG00000148362
Description: PAXX non-homologous end joining factor
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 65.56rCSI 45.77%PRS 25.91
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CSI 29.87rCSI 19.9%PRS 53.6
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CSI 17.9rCSI 44.31%PRS 22.55
-
CSI 17.63rCSI 11.88%PRS 30.21
-
CSI 17.42rCSI 22.83%PRS 34.43
-
CSI 16.31rCSI 16.52%PRS 76.78
-
CSI 14.13rCSI 18.79%PRS 26.64
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CSI 11.33rCSI 9%PRS 42.53
-
CSI 10.35rCSI 12.16%PRS 27.78
-
CSI 9.69rCSI 21.32%PRS 27.81
-
CSI 9.32rCSI 6.99%PRS 60.45
-
CSI 8.7rCSI 11.96%PRS 45.21
-
CSI 7.35rCSI 20.66%PRS 30.6
-
CSI 6.95rCSI 8.66%PRS 33.58
-
CSI 6.82rCSI 10.42%PRS 27.69
-
CSI 6.69rCSI 7.52%PRS 38.33
-
CSI 6.17rCSI 13.79%PRS 28.52
-
CSI 5.74rCSI 8.12%PRS 33.67
-
CSI 5.68rCSI 6.68%PRS 78.92
-
CSI 5.44rCSI 3.82%PRS 52.53
-
CSI 5.44rCSI 5.7%PRS 25.78
-
CSI 5.22rCSI 8.24%PRS 24.39
-
CSI 5.14rCSI 8.32%PRS 24.37
-
CSI 4.89rCSI 6.09%PRS 25.93
-
CSI 4.85rCSI 5.19%PRS 22.34
-
CSI 4.79rCSI 17.34%PRS 40.98
-
CSI 4.76rCSI 8.39%PRS 31.15
-
CSI 4.74rCSI 4.21%PRS 24.5
-
CSI 4.7rCSI 6.43%PRS 23.82
-
CSI 4.59rCSI 7.32%PRS 20.66
-
CSI 4.23rCSI 11.16%PRS 28.98
-
CSI 4.18rCSI 2.47%PRS 34.26
-
CSI 4.14rCSI 4.22%PRS 34.55
-
CSI 4.07rCSI 3.68%PRS 22.14
-
CSI 4.03rCSI 8.09%PRS 17.96
-
CSI 3.99rCSI 3.15%PRS 16.68
-
CSI 3.9rCSI 19.59%PRS 32.13
-
CSI 3.84rCSI 3.1%PRS 36.09
-
CSI 3.74rCSI 4.7%PRS 73.95
-
CSI 3.71rCSI 9.41%PRS 23.97
-
CSI 3.59rCSI 3.75%PRS 24.83
-
CSI 3.57rCSI 2.68%PRS 26.02
-
CSI 3.5rCSI 4.47%PRS 68.98
-
CSI 3.41rCSI 3.37%PRS 69.04
-
CSI 3.25rCSI 5.55%PRS 47.68
-
CSI 3.21rCSI 14.1%PRS 43.31
-
CSI 3.19rCSI 2.41%PRS 33.17
-
CSI 3.03rCSI 4.19%PRS 32.67
-
CSI 2.89rCSI 2.01%PRS 29.32
-
CSI 2.88rCSI 4.62%PRS 58.39
-
CSI 2.84rCSI 1.98%PRS 34.15
-
CSI 2.81rCSI 2.71%PRS 17.86
-
CSI 2.8rCSI 5.07%PRS 54.59
-
CSI 2.72rCSI 2.07%PRS 32.23
-
CSI 2.68rCSI 2.25%PRS 38.4
-
CSI 2.64rCSI 3.6%PRS 36.11
-
CSI 2.61rCSI 1.96%PRS 37.65
-
CSI 2.57rCSI 3.09%PRS 23.65
-
CSI 2.57rCSI 1.84%PRS 33.39
-
CSI 2.53rCSI 2.6%PRS 38.56
-
CSI 2.52rCSI 2.02%PRS 42.53
-
CSI 2.49rCSI 2.02%PRS 25.41
-
CSI 2.43rCSI 7.25%PRS 51.14
-
CSI 2.38rCSI 3.24%PRS 36.06
-
CSI 2.37rCSI 3.24%PRS 27.37
-
CSI 2.34rCSI 3.61%PRS 22.75
-
CSI 2.31rCSI 4.08%PRS 14.34
-
CSI 2.26rCSI 2.36%PRS 60.25
-
CSI 2.2rCSI 2.2%PRS 20.81
-
CSI 2.19rCSI 2.02%PRS 42.77
-
CSI 2.19rCSI 2.98%PRS 21.23
-
CSI 2.17rCSI 1.87%PRS 35.81
-
CSI 2.16rCSI 2.89%PRS 26.35
-
CSI 2.12rCSI 3.15%PRS 28.29
-
CSI 2.11rCSI 2.07%PRS 37.34
-
CSI 2.1rCSI 2.58%PRS 60.01
-
CSI 2.09rCSI 1.97%PRS 25.45
-
CSI 2.08rCSI 2.43%PRS 34.01
-
CSI 2.07rCSI 1.89%PRS 36.65
-
CSI 2.07rCSI 1.79%PRS 27.35
-
CSI 2.04rCSI 1.79%PRS 32.05
-
CSI 2.01rCSI 3.53%PRS 23.7
-
CSI 2rCSI 1.49%PRS 35.51
-
CSI 1.92rCSI 3.45%PRS 20.11
-
CSI 1.89rCSI 1.82%PRS 25.13
-
CSI 1.87rCSI 2.5%PRS 31.12
-
CSI 1.87rCSI 3.53%PRS 48.7
-
CSI 1.85rCSI 2.12%PRS 47
-
CSI 1.85rCSI 1.55%PRS 55.38
-
CSI 1.84rCSI 1.49%PRS 24.52
-
CSI 1.8rCSI 1.66%PRS 25.39
-
CSI 1.8rCSI 2.58%PRS 32.15
-
CSI 1.79rCSI 1.84%PRS 42.85
-
CSI 1.79rCSI 2.94%PRS 18.7
-
CSI 1.78rCSI 1.38%PRS 35.61
-
CSI 1.78rCSI 1.4%PRS 29.51
-
CSI 1.77rCSI 2.11%PRS 41.42
-
CSI 1.76rCSI 2.35%PRS 44.55
-
CSI 1.74rCSI 1.71%PRS 58.56
-
CSI 1.72rCSI 2.69%PRS 51.8
-
CSI 0.1rCSI 0.4%PRS 39.6%
-
CSI 0.1rCSI 1.0%PRS 56.2%
-
CSI 0.2rCSI 0.4%PRS 22.4%
-
CSI 0.2rCSI 1.1%PRS 35.4%
-
CSI 0.2rCSI 2.6%PRS 62.9%
-
CSI 0.3rCSI 2.2%PRS 44.9%
-
CSI 0.3rCSI 2.9%PRS 79.6%
-
CSI 0.3rCSI 3.5%PRS 70.9%
-
CSI 0.3rCSI 2.4%PRS 43.1%
-
CSI 0.3rCSI 1.6%PRS 54.5%
-
CSI 0.4rCSI 0.9%PRS 37.8%
-
CSI 0.4rCSI 1.9%PRS 42.2%
-
CSI 0.4rCSI 2.0%PRS 23.6%
-
CSI 0.5rCSI 4.4%PRS 73.1%
-
CSI 0.5rCSI 1.7%PRS 38.4%
-
CSI 0.5rCSI 1.4%PRS 27.2%
-
CSI 0.5rCSI 2.7%PRS 39.8%
-
CSI 0.5rCSI 2.7%PRS 40.2%
-
CSI 0.5rCSI 2.5%PRS 66.8%
-
CSI 0.6rCSI 1.3%PRS 24.8%
-
CSI 0.6rCSI 1.3%PRS 17.3%
-
CSI 0.6rCSI 1.9%PRS 33.3%
-
CSI 0.6rCSI 1.6%PRS 20.1%
-
CSI 0.6rCSI 3.3%PRS 51.4%
-
CSI 0.6rCSI 3.5%PRS 63.6%
-
CSI 0.6rCSI 1.7%PRS 31.4%
-
CSI 0.6rCSI 1.8%PRS 39.7%
-
CSI 0.7rCSI 2.9%PRS 22.1%
-
CSI 0.7rCSI 1.3%PRS 59.8%
-
CSI 0.7rCSI 0.7%PRS 28.7%
-
CSI 0.7rCSI 1.1%PRS 29.2%
-
CSI 0.7rCSI 1.0%PRS 37.5%
-
CSI 0.8rCSI 2.7%PRS 37.2%
-
CSI 0.8rCSI 1.5%PRS 30.8%
-
CSI 0.8rCSI 0.9%PRS 18.0%
-
CSI 0.8rCSI 6.0%PRS 57.4%
-
CSI 0.9rCSI 1.3%PRS 22.4%
-
CSI 0.9rCSI 1.7%PRS 24.9%
-
CSI 0.9rCSI 1.1%PRS 41.3%
-
CSI 0.9rCSI 2.3%PRS 57.7%
-
CSI 0.9rCSI 6.4%PRS 45.0%
-
CSI 0.9rCSI 1.5%PRS 18.6%
-
CSI 1.0rCSI 1.4%PRS 36.5%
-
CSI 1.0rCSI 2.8%PRS 36.4%
-
CSI 1.0rCSI 2.5%PRS 22.5%
-
CSI 1.0rCSI 1.5%PRS 27.2%
-
CSI 1.0rCSI 2.8%PRS 42.6%
-
CSI 1.0rCSI 1.7%PRS 32.7%
-
CSI 1.0rCSI 3.5%PRS 40.8%
-
CSI 1.0rCSI 2.4%PRS 35.5%
-
CSI 1.0rCSI 1.0%PRS 26.1%
-
CSI 1.0rCSI 1.3%PRS 21.4%
-
CSI 1.0rCSI 2.7%PRS 30.3%
-
CSI 1.1rCSI 1.6%PRS 31.4%
-
CSI 1.1rCSI 1.3%PRS 28.9%
-
CSI 1.1rCSI 1.8%PRS 20.5%
-
CSI 1.2rCSI 6.0%PRS 46.0%
-
CSI 1.2rCSI 1.8%PRS 24.4%
-
CSI 1.2rCSI 16.2%PRS 75.4%
-
CSI 1.2rCSI 1.2%PRS 25.2%
-
CSI 1.2rCSI 1.7%PRS 33.6%
-
CSI 1.2rCSI 1.7%PRS 27.1%
-
CSI 1.2rCSI 2.5%PRS 48.4%
-
CSI 1.2rCSI 1.5%PRS 31.5%
-
CSI 1.2rCSI 1.9%PRS 38.7%
-
CSI 1.2rCSI 1.8%PRS 25.7%
-
CSI 1.3rCSI 2.4%PRS 52.6%
-
CSI 1.3rCSI 2.9%PRS 45.1%
-
CSI 1.3rCSI 1.1%PRS 30.7%
-
CSI 1.3rCSI 5.0%PRS 40.0%
-
CSI 1.3rCSI 3.3%PRS 30.4%
-
CSI 1.3rCSI 2.0%PRS 41.5%
-
CSI 1.3rCSI 1.8%PRS 24.6%
-
CSI 1.3rCSI 1.7%PRS 28.0%
-
CSI 1.3rCSI 2.4%PRS 20.6%
-
CSI 1.3rCSI 2.0%PRS 24.9%
-
CSI 1.3rCSI 31.0%PRS 88.8%
-
CSI 1.4rCSI 26.0%PRS 58.0%
-
CSI 1.4rCSI 4.4%PRS 28.7%
-
CSI 1.4rCSI 2.8%PRS 34.8%
-
CSI 1.4rCSI 3.6%PRS 45.4%
-
CSI 1.4rCSI 1.9%PRS 26.9%
-
CSI 1.4rCSI 2.6%PRS 45.3%
-
CSI 1.5rCSI 2.1%PRS 31.7%
-
CSI 1.5rCSI 1.4%PRS 28.8%
-
CSI 1.5rCSI 2.2%PRS 27.7%
-
CSI 1.5rCSI 8.1%PRS 67.2%
-
CSI 1.5rCSI 1.6%PRS 22.7%
-
CSI 1.5rCSI 1.9%PRS 28.0%
-
CSI 1.5rCSI 2.4%PRS 26.6%
-
CSI 1.5rCSI 1.9%PRS 13.7%
-
CSI 1.5rCSI 2.7%PRS 39.1%
-
CSI 1.5rCSI 1.2%PRS 23.5%
-
CSI 1.5rCSI 1.9%PRS 30.1%
-
CSI 1.5rCSI 1.8%PRS 21.1%
-
CSI 1.5rCSI 1.9%PRS 29.4%
-
CSI 1.5rCSI 3.2%PRS 24.1%
-
CSI 1.5rCSI 3.0%PRS 37.8%
-
CSI 1.6rCSI 1.2%PRS 22.8%
-
CSI 1.6rCSI 1.8%PRS 57.4%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3755075645
Symbol: PAXX_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25941166
Title: XLS (c9orf142) is a new component of mammalian DNA double-stranded break repair.
PubMed ID: 25941166
DOI: 10.1038/cdd.2015.22
PubMed ID: 27601299
Title: Specific roles of XRCC4 paralogs PAXX and XLF during V(D)J recombination.
PubMed ID: 27601299
PubMed ID: 27705800
Title: PAXX is an accessory c-NHEJ factor that associates with Ku70 and has overlapping functions with XLF.
PubMed ID: 27705800
PubMed ID: 27703001
Title: Different DNA End Configurations Dictate Which NHEJ Components Are Most Important for Joining Efficiency.
PubMed ID: 27703001
PubMed ID: 27063109
Title: The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins.
PubMed ID: 27063109
DOI: 10.1038/ncomms11242
PubMed ID: 29144403
Title: The Non-Homologous End Joining Protein PAXX Acts to Restrict HSV-1 Infection.
PubMed ID: 29144403
DOI: 10.3390/v9110342
PubMed ID: 30250067
Title: PAXX and its paralogs synergistically direct DNA polymerase lambda activity in DNA repair.
PubMed ID: 30250067
PubMed ID: 25670504
Title: Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway.
PubMed ID: 25670504
DOI: 10.1038/ncomms7233
PubMed ID: 25574025
Title: DNA repair. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair.
PubMed ID: 25574025
Sequence Information:
- Length: 204
- Mass: 21640
- Checksum: 5F9737ED9463B6BE
- Sequence:
MDPLSPPLCT LPPGPEPPRF VCYCEGEESG EGDRGGFNLY VTDAAELWST CFTPDSLAAL KARFGLSAAE DITPRFRAAC EQQAVALTLQ EDRASLTLSG GPSALAFDLS KVPGPEAAPR LRALTLGLAK RVWSLERRLA AAEETAVSPR KSPRPAGPQL FLPDPDPQRG GPGPGVRRRC PGESLINPGF KSKKPAGGVD FDET