TCEAL4 | ENSG00000133142 | NCBI 79921

Details for: TCEAL4

Gene ID: 79921

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: TCEAL4

Ensembl ID: ENSG00000133142

Description: transcription elongation factor A like 4

Cell Significance Landscape

Display Count:

Associated with

Nucleus
(GO:0005634)
Protein binding
(GO:0005515)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

pancreatic D cell CL0000173

CSI 49.86

rCSI 49.04%

PRS 38.32
extravillous trophoblast CL0008036

CSI 45.29

rCSI 56.03%

PRS 32.49
fallopian tube secretory epithelial cell CL4030006

CSI 44.97

rCSI 43.29%

PRS 36.88
peripheral nervous system neuron CL2000032

CSI 39.66

rCSI 54.04%

PRS 31.1
keratinocyte CL0000312

CSI 35.5

rCSI 29.76%

PRS 41.2
ciliated epithelial cell CL0000067

CSI 35.34

rCSI 31.08%

PRS 27.06
stromal cell of ovary CL0002132

CSI 27.74

rCSI 76.23%

PRS 52.06
pancreatic A cell CL0000171

CSI 26.57

rCSI 27.84%

PRS 38.24
type B pancreatic cell CL0000169

CSI 25.25

rCSI 55.91%

PRS 33.56
retina horizontal cell CL0000745

CSI 23.9

rCSI 36.44%

PRS 33.52
microcirculation associated smooth muscle cell CL0008035

CSI 22.55

rCSI 65.27%

PRS 38.94
OFF-bipolar cell CL0000750

CSI 21.65

rCSI 29.6%

PRS 46.99
pancreatic ductal cell CL0002079

CSI 20.7

rCSI 40.26%

PRS 37.7
ON-bipolar cell CL0000749

CSI 18.46

rCSI 27.43%

PRS 39.44
bronchus fibroblast of lung CL2000093

CSI 18.28

rCSI 14.86%

PRS 37.04
enteric smooth muscle cell CL0002504

CSI 18.1

rCSI 25.83%

PRS 38.81
CD14-positive, CD16-positive monocyte CL0002397

CSI 17.02

rCSI 22.3%

PRS 48.69
alveolar type 1 fibroblast cell CL4028004

CSI 16.67

rCSI 18.26%

PRS 39.88
hematopoietic stem cell CL0000037

CSI 15.83

rCSI 10.52%

PRS 40.39
pancreatic PP cell CL0002275

CSI 15.57

rCSI 61.99%

PRS 52.1
mesodermal cell CL0000222

CSI 15.06

rCSI 18.07%

PRS 34.62
group 3 innate lymphoid cell CL0001071

CSI 14.77

rCSI 11.1%

PRS 38.86
Mueller cell CL0000636

CSI 14.4

rCSI 32.86%

PRS 31.2
myofibroblast cell CL0000186

CSI 14.34

rCSI 19.86%

PRS 42.61
glandular epithelial cell CL0000150

CSI 13.98

rCSI 36.81%

PRS 59.51
luminal epithelial cell of mammary gland CL0002326

CSI 13.51

rCSI 24.55%

PRS 51.89
pro-B cell CL0000826

CSI 13.32

rCSI 11.03%

PRS 36.91
stromal cell CL0000499

CSI 13.19

rCSI 37.11%

PRS 38.76
smooth muscle cell CL0000192

CSI 12.92

rCSI 30.8%

PRS 56.78
pancreatic epsilon cell CL0005019

CSI 12.71

rCSI 59.26%

PRS 60.71
cerebral cortex endothelial cell CL1001602

CSI 12.66

rCSI 21.89%

PRS 28.39
mononuclear phagocyte CL0000113

CSI 12.19

rCSI 26.84%

PRS 40.09
mucus secreting cell CL0000319

CSI 12.01

rCSI 19.07%

PRS 45.5
neural crest cell CL0011012

CSI 11.8

rCSI 9.33%

PRS 25.79
fibroblast of lung CL0002553

CSI 11.78

rCSI 10.96%

PRS 35.96
forebrain radial glial cell CL0013000

CSI 11.22

rCSI 36.01%

PRS 44.59
retinal pigment epithelial cell CL0002586

CSI 11.02

rCSI 21.88%

PRS 36.25
epithelial cell CL0000066

CSI 10.74

rCSI 16.5%

PRS 40.82
CD8-positive, alpha-beta memory T cell CL0000909

CSI 10.51

rCSI 10.98%

PRS 68.7
intestine goblet cell CL0019031

CSI 10.36

rCSI 9.2%

PRS 35.67
podocyte CL0000653

CSI 10.04

rCSI 44.6%

PRS 34.82
intestinal epithelial cell CL0002563

CSI 9.91

rCSI 10.36%

PRS 36.33
blood vessel endothelial cell CL0000071

CSI 9.69

rCSI 20.1%

PRS 35.06
renal interstitial pericyte CL1001318

CSI 9.64

rCSI 26.57%

PRS 33.94
secretory cell CL0000151

CSI 9.63

rCSI 10.05%

PRS 36.76
melanocyte CL0000148

CSI 9.53

rCSI 7.06%

PRS 31.1
Cajal-Retzius cell CL0000695

CSI 9.5

rCSI 74.44%

PRS 54.83
colonocyte CL1000347

CSI 9.21

rCSI 13.2%

PRS 44.2
perivascular cell CL4033054

CSI 9.17

rCSI 12.53%

PRS 40.31
P/D1 enteroendocrine cell CL0002268

CSI 9.16

rCSI 49.87%

PRS 60.81
pvalb GABAergic cortical interneuron CL4023018

CSI 9.16

rCSI 11.4%

PRS 21.9
amacrine cell CL0000561

CSI 9.1

rCSI 26.36%

PRS 29.19
cerebral cortex GABAergic interneuron CL0010011

CSI 8.9

rCSI 26.26%

PRS 40.52
CD1c-positive myeloid dendritic cell CL0002399

CSI 8.66

rCSI 10.46%

PRS 42.81
enteroglial cell CL4040002

CSI 8.64

rCSI 45.44%

PRS 46.48
adventitial cell CL0002503

CSI 8.64

rCSI 20.64%

PRS 47.6
pancreatic stellate cell CL0002410

CSI 8.63

rCSI 50.22%

PRS 47.55
smooth muscle cell of prostate CL1000487

CSI 8.62

rCSI 50.7%

PRS 67.89
ionocyte CL0005006

CSI 8.46

rCSI 9.07%

PRS 33.97
kidney distal convoluted tubule epithelial cell CL1000849

CSI 8.33

rCSI 88.24%

PRS 39.48
pulmonary ionocyte CL0017000

CSI 8.25

rCSI 10.05%

PRS 43.2
skin fibroblast CL0002620

CSI 8.23

rCSI 7.1%

PRS 45.93
alveolar adventitial fibroblast CL4028006

CSI 8.21

rCSI 12.97%

PRS 36.87
megakaryocyte CL0000556

CSI 8.17

rCSI 35.44%

PRS 52.66
ciliated cell CL0000064

CSI 8.06

rCSI 13.06%

PRS 35.32
midzonal region hepatocyte CL0019028

CSI 8.05

rCSI 18.9%

PRS 46.21
enteroendocrine cell CL0000164

CSI 7.73

rCSI 10.57%

PRS 39
hepatic stellate cell CL0000632

CSI 7.72

rCSI 28.91%

PRS 30.84
pancreatic acinar cell CL0002064

CSI 7.6

rCSI 10.1%

PRS 40.03
conjunctival epithelial cell CL1000432

CSI 7.6

rCSI 11.6%

PRS 36.5
epithelial cell of lung CL0000082

CSI 7.51

rCSI 6.22%

PRS 34.62
myoepithelial cell CL0000185

CSI 7.48

rCSI 18.93%

PRS 43.66
smooth muscle cell of the pulmonary artery CL0002591

CSI 7.48

rCSI 57.31%

PRS 59.07
neuroblast (sensu Vertebrata) CL0000031

CSI 7.42

rCSI 9.52%

PRS 34.48
placental villous trophoblast CL2000060

CSI 7.35

rCSI 11.36%

PRS 34.31
lung ciliated cell CL1000271

CSI 7.33

rCSI 8.48%

PRS 27.74
retinal ganglion cell CL0000740

CSI 7.29

rCSI 16.1%

PRS 26.64
interstitial cell of Cajal CL0002088

CSI 7.17

rCSI 9.12%

PRS 40.82
endothelial cell of artery CL1000413

CSI 7.11

rCSI 10.41%

PRS 73.8
Schwann cell CL0002573

CSI 7.09

rCSI 20.14%

PRS 37.04
pulmonary capillary endothelial cell CL4028001

CSI 6.98

rCSI 13.31%

PRS 52.64
ependymal cell CL0000065

CSI 6.95

rCSI 14.11%

PRS 21.86
elicited macrophage CL0000861

CSI 6.95

rCSI 6.38%

PRS 42.52
radial glial cell CL0000681

CSI 6.83

rCSI 9.49%

PRS 36.15
blood vessel smooth muscle cell CL0019018

CSI 6.83

rCSI 55.51%

PRS 32.45
mammary gland epithelial cell CL0002327

CSI 6.82

rCSI 23.93%

PRS 52.38
alveolar macrophage CL0000583

CSI 6.81

rCSI 11.22%

PRS 41.12
differentiation-committed oligodendrocyte precursor CL4023059

CSI 6.78

rCSI 12.32%

PRS 31.44
mast cell CL0000097

CSI 6.71

rCSI 14.49%

PRS 71.48
kidney epithelial cell CL0002518

CSI 6.65

rCSI 12.69%

PRS 59.89
pulmonary alveolar type 2 cell CL0002063

CSI 6.61

rCSI 10.25%

PRS 46.72
glutamatergic neuron CL0000679

CSI 6.51

rCSI 13.38%

PRS 32.96
keratocyte CL0002363

CSI 6.42

rCSI 15.44%

PRS 47
myeloid lineage restricted progenitor cell CL0000839

CSI 6.27

rCSI 32.36%

PRS 59.87
uterine smooth muscle cell CL0002601

CSI 6.24

rCSI 41.07%

PRS 76.1
plasmablast CL0000980

CSI 6.24

rCSI 4.91%

PRS 41.9
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 6.22

rCSI 15.12%

PRS 22.52
megakaryocyte-erythroid progenitor cell CL0000050

CSI 6.16

rCSI 5.57%

PRS 33.24
stem cell CL0000034

CSI 6.11

rCSI 5.89%

PRS 28.08
retinal rod cell CL0000604

CSI 6.03

rCSI 10.63%

PRS 35.16

Merkel cell CL0000242

CSI 0.2

rCSI 4.6%

PRS 90.3%
mesenchymal lymphangioblast CL0005021

CSI 0.2

rCSI 5.7%

PRS 76.2%
epithelial cell of urethra CL1000296

CSI 0.3

rCSI 7.0%

PRS 65.7%
tracheal goblet cell CL1000329

CSI 0.4

rCSI 0.8%

PRS 56.6%
L6b glutamatergic cortical neuron CL4023038

CSI 0.4

rCSI 1.2%

PRS 24.2%
follicular dendritic cell CL0000442

CSI 0.5

rCSI 7.7%

PRS 77.9%
primitive red blood cell CL0002355

CSI 0.5

rCSI 2.7%

PRS 51.3%
kidney granular cell CL0000648

CSI 0.5

rCSI 7.4%

PRS 71.4%
respiratory goblet cell CL0002370

CSI 0.5

rCSI 5.8%

PRS 57.3%
cone retinal bipolar cell CL0000752

CSI 0.6

rCSI 7.5%

PRS 65.3%
vasa recta descending limb cell CL1001285

CSI 0.6

rCSI 4.7%

PRS 72.1%
colon macrophage CL0009038

CSI 0.6

rCSI 2.7%

PRS 59.6%
parietal epithelial cell CL1000452

CSI 0.6

rCSI 1.6%

PRS 30.8%
basal cell of epithelium of trachea CL1000348

CSI 0.6

rCSI 4.3%

PRS 63.9%
neuroplacodal cell CL0000032

CSI 0.7

rCSI 6.0%

PRS 58.9%
prostate gland microvascular endothelial cell CL2000059

CSI 0.7

rCSI 16.0%

PRS 66.8%
kidney loop of Henle epithelial cell CL1000909

CSI 0.7

rCSI 14.6%

PRS 84.5%
peptic cell CL0000155

CSI 0.7

rCSI 7.1%

PRS 65.1%
vein endothelial cell of respiratory system CL4033008

CSI 0.8

rCSI 5.3%

PRS 56.3%
epithelial cell of nephron CL1000449

CSI 0.8

rCSI 7.3%

PRS 79.9%
late pro-B cell CL0002048

CSI 0.8

rCSI 2.1%

PRS 68.4%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 0.9

rCSI 1.6%

PRS 22.4%
myeloid dendritic cell, human CL0001057

CSI 0.9

rCSI 5.2%

PRS 70.6%
type L enteroendocrine cell CL0002279

CSI 0.9

rCSI 1.7%

PRS 57.1%
basal cell of epidermis CL0002187

CSI 0.9

rCSI 1.7%

PRS 23.9%
endocardial cell CL0002350

CSI 1.0

rCSI 4.7%

PRS 39.0%
acinar cell of salivary gland CL0002623

CSI 1.0

rCSI 23.1%

PRS 59.2%
kidney connecting tubule epithelial cell CL1000768

CSI 1.0

rCSI 2.5%

PRS 28.5%
basophil CL0000767

CSI 1.1

rCSI 2.3%

PRS 58.0%
germinal center B cell CL0000844

CSI 1.1

rCSI 3.2%

PRS 60.5%
transit amplifying cell CL0009010

CSI 1.1

rCSI 1.7%

PRS 52.5%
syncytiotrophoblast cell CL0000525

CSI 1.1

rCSI 3.2%

PRS 54.6%
Hofbauer cell CL3000001

CSI 1.1

rCSI 2.1%

PRS 45.2%
tracheobronchial serous cell CL0019001

CSI 1.1

rCSI 5.0%

PRS 53.5%
cerebellar granule cell CL0001031

CSI 1.2

rCSI 1.7%

PRS 33.3%
neuroendocrine cell CL0000165

CSI 1.2

rCSI 4.4%

PRS 56.3%
colon goblet cell CL0009039

CSI 1.2

rCSI 2.8%

PRS 48.7%
near-projecting glutamatergic cortical neuron CL4023012

CSI 1.2

rCSI 4.4%

PRS 24.0%
glycinergic amacrine cell CL4030028

CSI 1.2

rCSI 3.1%

PRS 36.4%
chondrocyte CL0000138

CSI 1.2

rCSI 1.9%

PRS 30.7%
enteroendocrine cell of colon CL0009042

CSI 1.2

rCSI 5.7%

PRS 64.3%
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 1.2

rCSI 2.8%

PRS 35.5%
fibroblast of breast CL4006000

CSI 1.3

rCSI 5.3%

PRS 61.8%
respiratory epithelial cell CL0002368

CSI 1.3

rCSI 8.0%

PRS 73.2%
ventricular cardiac muscle cell CL2000046

CSI 1.3

rCSI 4.5%

PRS 73.1%
enterocyte CL0000584

CSI 1.4

rCSI 2.2%

PRS 46.5%
intermediate monocyte CL0002393

CSI 1.4

rCSI 2.0%

PRS 37.4%
indirect pathway medium spiny neuron CL4023029

CSI 1.4

rCSI 33.1%

PRS 23.4%
Langerhans cell CL0000453

CSI 1.4

rCSI 2.2%

PRS 53.7%
hair follicular keratinocyte CL2000092

CSI 1.5

rCSI 25.7%

PRS 74.8%
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 1.5

rCSI 4.6%

PRS 48.4%
lamp5 GABAergic cortical interneuron CL4023011

CSI 1.6

rCSI 2.6%

PRS 23.2%
common lymphoid progenitor CL0000051

CSI 1.6

rCSI 2.2%

PRS 58.6%
muscle cell CL0000187

CSI 1.7

rCSI 3.4%

PRS 58.9%
intestinal tuft cell CL0019032

CSI 1.7

rCSI 2.6%

PRS 40.5%
mesenchymal stem cell of adipose tissue CL0002570

CSI 1.7

rCSI 9.7%

PRS 58.4%
retinal cone cell CL0000573

CSI 1.7

rCSI 2.8%

PRS 28.4%
lung endothelial cell CL1001567

CSI 1.7

rCSI 4.1%

PRS 63.7%
mucous neck cell CL0000651

CSI 1.8

rCSI 2.5%

PRS 50.0%
macroglial cell CL0000126

CSI 1.8

rCSI 4.6%

PRS 40.4%
paneth cell CL0000510

CSI 1.8

rCSI 2.7%

PRS 52.7%
bronchial goblet cell CL1000312

CSI 1.8

rCSI 7.2%

PRS 58.7%
deuterosomal cell CL4033044

CSI 1.8

rCSI 6.1%

PRS 47.4%
foveolar cell of stomach CL0002179

CSI 1.8

rCSI 3.9%

PRS 51.2%
hematopoietic multipotent progenitor cell CL0000837

CSI 1.9

rCSI 4.7%

PRS 52.7%
M cell of gut CL0000682

CSI 2.0

rCSI 2.1%

PRS 52.1%
primordial germ cell CL0000670

CSI 2.0

rCSI 10.0%

PRS 81.2%
odontoblast CL0000060

CSI 2.0

rCSI 45.5%

PRS 75.4%
granulocyte monocyte progenitor cell CL0000557

CSI 2.1

rCSI 1.8%

PRS 39.7%
erythroid progenitor cell CL0000038

CSI 2.1

rCSI 11.9%

PRS 47.2%
neural progenitor cell CL0011020

CSI 2.1

rCSI 9.2%

PRS 31.2%
brush cell CL0002204

CSI 2.2

rCSI 4.3%

PRS 64.2%
plasmacytoid dendritic cell, human CL0001058

CSI 2.2

rCSI 1.5%

PRS 37.9%
endothelial cell of placenta CL0009092

CSI 2.3

rCSI 11.1%

PRS 46.7%
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 2.3

rCSI 3.2%

PRS 33.9%
pluripotent stem cell CL0002248

CSI 2.3

rCSI 68.2%

PRS 61.5%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 2.3

rCSI 13.5%

PRS 24.4%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 2.3

rCSI 8.2%

PRS 22.2%
progenitor cell CL0011026

CSI 2.3

rCSI 5.0%

PRS 43.0%
enteroendocrine cell of small intestine CL0009006

CSI 2.4

rCSI 5.2%

PRS 50.6%
rod bipolar cell CL0000751

CSI 2.4

rCSI 4.2%

PRS 30.6%
transit amplifying cell of colon CL0009011

CSI 2.4

rCSI 2.8%

PRS 39.9%
duct epithelial cell CL0000068

CSI 2.4

rCSI 3.5%

PRS 38.6%
glial cell CL0000125

CSI 2.4

rCSI 9.1%

PRS 32.0%
VIP GABAergic cortical interneuron CL4023016

CSI 2.4

rCSI 2.9%

PRS 23.1%
nasal mucosa goblet cell CL0002480

CSI 2.5

rCSI 2.8%

PRS 47.1%
renal principal cell CL0005009

CSI 2.5

rCSI 6.4%

PRS 42.3%
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 2.5

rCSI 2.4%

PRS 50.9%
class switched memory B cell CL0000972

CSI 2.6

rCSI 1.9%

PRS 54.2%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 2.7

rCSI 7.0%

PRS 33.2%
enteric neuron CL0007011

CSI 2.7

rCSI 40.3%

PRS 60.4%
promyelocyte CL0000836

CSI 2.7

rCSI 4.0%

PRS 46.1%
sst GABAergic cortical interneuron CL4023017

CSI 2.8

rCSI 3.6%

PRS 24.0%
common dendritic progenitor CL0001029

CSI 2.9

rCSI 3.6%

PRS 45.0%
granulocyte CL0000094

CSI 2.9

rCSI 4.5%

PRS 44.6%
epithelial cell of proximal tubule CL0002306

CSI 3.0

rCSI 7.2%

PRS 33.6%
cardiac neuron CL0010022

CSI 3.0

rCSI 9.5%

PRS 33.2%
Kupffer cell CL0000091

CSI 3.0

rCSI 6.8%

PRS 35.7%
mature T cell CL0002419

CSI 3.0

rCSI 2.4%

PRS 51.3%
basal-myoepithelial cell of mammary gland CL0002324

CSI 3.1

rCSI 5.9%

PRS 60.7%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

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Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

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Target Cell Context(s): Comma-separated if multiple.

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Node Color (Target Cell CSI, relative to current network):
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- Low
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Node Size: Proportional to Target Cell CSI magnitude
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [TCEAL4](/details-gene/79921) (transcription elongation factor A like 4) is a protein-coding gene located on the X chromosome at position Xq22.2. Its name suggests a role in the regulation of gene transcription. Consistent with this, functional annotations confirm its localization to the [nucleus](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) and its capacity for [protein binding](https://www.ebi.ac.uk/QuickGO/term/GO:0005515). Expression data reveals that [TCEAL4](/details-gene/79921) is a significant gene in a diverse range of cell types, showing particularly high significance in endocrine cells of the pancreas, such as the [pancreatic D cell](/details-cell/CL0000173), as well as in specialized epithelial cells like the [extravillous trophoblast](/details-cell/CL0008036) and various neuronal populations. This broad but distinct expression pattern suggests it may act as a transcriptional co-factor involved in maintaining the specialized functions of multiple, unrelated cell lineages. ## Cellular Roles and Expression Landscape The **Overall** expression profile of [TCEAL4](/details-gene/79921) indicates its importance across several distinct biological systems, rather than being confined to a single tissue or lineage. - **Endocrine System:** The gene shows prominent significance in the endocrine pancreas, with high Cell Significance Index (CSI) scores in [pancreatic D cell](/details-cell/CL0000173) (CSI: 49.86), [pancreatic A cell](/details-cell/CL0000171) (CSI: 26.57), and [type B pancreatic cell](/details-cell/CL0000169) (CSI: 25.25). This strong association with all three major islet cell types suggests a fundamental role in regulating the transcriptional programs essential for hormone production and glucose homeostasis. - **Epithelial and Reproductive Tissues:** [TCEAL4](/details-gene/79921) is a key marker in several epithelial contexts. It is most significant in [extravillous trophoblast](/details-cell/CL0008036) (CSI: 45.29), a cell critical for placental implantation, and [fallopian tube secretory epithelial cell](/details-cell/CL4030006) (CSI: 44.97), indicating a potential function in female reproductive biology and embryonic development. Its relevance extends to other epithelial barriers, including [keratinocyte](/details-cell/CL0000312) and [ciliated epithelial cell](/details-cell/CL0000067). - **Nervous System:** The gene is also highly significant in neuronal populations, including [peripheral nervous system neuron](/details-cell/CL2000032) (CSI: 39.66) and multiple cell types within the retina, such as the [retina horizontal cell](/details-cell/CL0000745), [OFF-bipolar cell](/details-cell/CL0000750), and [ON-bipolar cell](/details-cell/CL0000749). This pattern suggests a role in maintaining the specialized transcriptional identity and function of these post-mitotic cells. Interestingly, while an early report identified [TCEAL4](/details-gene/79921) as a B lymphocyte activation-related gene ([Link](https://pubmed.ncbi.nlm.nih.gov/12905813)), the aggregated expression data does not highlight immune cells as top expressing lineages. This may suggest its role in lymphocytes is context-dependent or induced upon specific stimulation rather than being a constitutive marker. ## Pathways and Molecular Function The functional role of [TCEAL4](/details-gene/79921) is primarily inferred from its name and limited Gene Ontology annotations. As a "transcription elongation factor A like" protein, it is hypothesized to be involved in modulating the processivity of RNA polymerase during the elongation phase of transcription. This function is supported by its confirmed localization to the [nucleus](https://www.ebi.ac.uk/QuickGO/term/GO:0005634), the site of transcription. The primary molecular function assigned to [TCEAL4](/details-gene/79921) is [protein binding](https://www.ebi.ac.uk/QuickGO/term/GO:0005515). This suggests it does not function in isolation but rather as a component of larger protein complexes. It likely acts as an adaptor or scaffold protein that recruits other factors to the transcriptional machinery. The wide variety of cell types where it is prominently expressed implies that its binding partners may be cell-type specific, allowing [TCEAL4](/details-gene/79921) to contribute to the regulation of diverse and specialized gene expression programs, from hormone synthesis in the pancreas to synaptic function in neurons. ## Research Directions The broad expression of [TCEAL4](/details-gene/79921) in terminally differentiated cells with highly specialized functions, combined with its putative role in transcription, makes it an intriguing subject for further investigation. **Proposed Hypotheses:** 1. Given its high significance across pancreatic islet cells ([pancreatic D cell](/details-cell/CL0000173), A, and B cells), we hypothesize that **[TCEAL4](/details-gene/79921) is a crucial co-factor for lineage-defining transcription factors (e.g., PDX1, NKX6-1, ARX) that maintain islet cell identity and regulate hormone gene expression.** Its disruption could lead to islet cell dysfunction and metabolic disease. 2. Based on its top-ranking expression in [extravillous trophoblast](/details-cell/CL0008036), a cell type essential for placental invasion, we hypothesize that **[TCEAL4](/details-gene/79921) regulates the expression of genes involved in epithelial-mesenchymal transition (EMT) and matrix remodeling, thereby controlling uterine invasion during placentation.** Dysregulation of [TCEAL4](/details-gene/79921) could be implicated in pathologies like pre-eclampsia or intrauterine growth restriction. **Experimental Approach:** To test the first hypothesis regarding its role in pancreatic islet cells, a definitive experiment would involve generating a [TCEAL4](/details-gene/79921) knockout human pluripotent stem cell (hPSC) line using CRISPR-Cas9. These knockout hPSCs, along with isogenic wild-type controls, would be subjected to a directed differentiation protocol to generate pancreatic islet-like organoids. A multi-omics approach would then be used for characterization: single-cell RNA sequencing to assess perturbations in cell fate decisions and gene regulatory networks, and functional assays, such as glucose-stimulated hormone secretion measurements, to determine the physiological impact of [TCEAL4](/details-gene/79921) loss on islet function. **Therapeutic Potential:** Currently, the therapeutic potential of [TCEAL4](/details-gene/79921) is low and speculative. Its nature as a nuclear protein involved in the fundamental process of transcription makes it a difficult drug target. Furthermore, its broad expression pattern across multiple essential tissues, including the pancreas and nervous system, raises a high risk of systemic off-target toxicity for any inhibitor. Before it can be considered a viable therapeutic target, a clear and specific link to a disease state where its expression or function is uniquely altered (e.g., in a specific cancer subtype or a developmental disorder) must be established.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Transcription elongation factor A protein-like 4

Genular Protein ID: 3506570685

Symbol: TCAL4_HUMAN

Name: Transcription elongation factor A protein-like 4

UniProtKB Accession Codes:

Q96EI5 Q8WY12 Q9H2H1 Q9H775

Database IDs:

Citations:

PubMed ID: 12905813

Title: Cloning of human B lymphocyte activation-related novel gene.

PubMed ID: 12905813

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

Length: 215
Mass: 24647
Checksum: 53420116CD9A7A0B
Sequence:

MEKLYSENEG MASNQGKMEN EEQPQDERKP EVTCTLEDKK LENEGKTENK GKTGDEEMLK 
DKGKPESEGE AKEGKSEREG ESEMEGGSER EGKPEIEGKP ESEGEPGSET RAAGKRPAED 
DVPRKAKRKT NKGLAHYLKE YKEAIHDMNF SNEDMIREFD NMAKVQDEKR KSKQKLGAFL 
WMQRNLQDPF YPRGPREFRG GCRAPRRDIE DIPYV

Details for: TCEAL4

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Cloning of human B lymphocyte activation-related novel gene. PubMed ID: 12905813

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence of the human X chromosome. PubMed ID: 15772651

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569