Details for: UQCC2
Gene ID: 84300
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: UQCC2
Ensembl ID: ENSG00000137288
Description: ubiquinol-cytochrome c reductase complex assembly factor 2
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 46.3rCSI 48.51%PRS 41.51
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CSI 39.37rCSI 38.72%PRS 41.38
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CSI 33.77rCSI 29.24%PRS 42.89
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CSI 33.71rCSI 46.09%PRS 49.5
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CSI 28.3rCSI 28.25%PRS 33.9
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CSI 27.44rCSI 40.15%PRS 41.82
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CSI 27.23rCSI 24.59%PRS 36.01
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CSI 26.47rCSI 38.18%PRS 49.1
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CSI 25.5rCSI 20.62%PRS 39.63
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CSI 25.28rCSI 29.69%PRS 42.92
-
CSI 21.72rCSI 20.94%PRS 30.71
-
CSI 18.09rCSI 34.15%PRS 48.45
-
CSI 17.49rCSI 26%PRS 42.29
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CSI 16.13rCSI 21.44%PRS 43.44
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CSI 15.89rCSI 27.22%PRS 48.25
-
CSI 15.06rCSI 20.93%PRS 38.92
-
CSI 14.42rCSI 18.09%PRS 48.17
-
CSI 14.24rCSI 22.92%PRS 31.02
-
CSI 13.83rCSI 30.19%PRS 59.29
-
CSI 13.35rCSI 29.56%PRS 36.47
-
CSI 13.33rCSI 10.53%PRS 28.24
-
CSI 12.61rCSI 12.14%PRS 39.73
-
CSI 12.31rCSI 27.93%PRS 44.94
-
CSI 12.22rCSI 23.76%PRS 40.85
-
CSI 11.94rCSI 9.89%PRS 37.69
-
CSI 11.79rCSI 8.19%PRS 46.85
-
CSI 11.69rCSI 8.69%PRS 51.67
-
CSI 11.68rCSI 9.49%PRS 40.08
-
CSI 11.08rCSI 16.9%PRS 36.26
-
CSI 10.82rCSI 14.17%PRS 51.89
-
CSI 10.11rCSI 40.38%PRS 61.14
-
CSI 10.1rCSI 34.14%PRS 49.73
-
CSI 10.06rCSI 15.6%PRS 49.37
-
CSI 9.61rCSI 7.27%PRS 50.53
-
CSI 9.53rCSI 27.46%PRS 57.18
-
CSI 9.53rCSI 32.63%PRS 74.21
-
CSI 8.91rCSI 12.34%PRS 44.9
-
CSI 8.78rCSI 10.14%PRS 34.26
-
CSI 8.77rCSI 14.45%PRS 44.2
-
CSI 8.71rCSI 12.75%PRS 39.56
-
CSI 8.53rCSI 27.67%PRS 42.64
-
CSI 8.49rCSI 45.83%PRS 54.32
-
CSI 8.37rCSI 12.36%PRS 56.03
-
CSI 8.24rCSI 28.9%PRS 55
-
CSI 8.22rCSI 14.48%PRS 37.96
-
CSI 8.19rCSI 14.71%PRS 33.31
-
CSI 7.97rCSI 8.32%PRS 39.73
-
CSI 7.91rCSI 11.36%PRS 31.63
-
CSI 7.86rCSI 18.76%PRS 50.37
-
CSI 7.81rCSI 45.47%PRS 50.26
-
CSI 7.7rCSI 13.73%PRS 55.05
-
CSI 7.68rCSI 10.49%PRS 43.65
-
CSI 7.65rCSI 9.32%PRS 46.29
-
CSI 7.39rCSI 11.68%PRS 40
-
CSI 7.27rCSI 5.44%PRS 53.22
-
CSI 7.1rCSI 11.38%PRS 68.74
-
CSI 7.06rCSI 15.55%PRS 42.9
-
CSI 7.03rCSI 5.53%PRS 45.01
-
CSI 7rCSI 16.17%PRS 32.21
-
CSI 6.99rCSI 10.74%PRS 42.82
-
CSI 6.88rCSI 7.01%PRS 51.36
-
CSI 6.83rCSI 17.34%PRS 36.14
-
CSI 6.77rCSI 10.02%PRS 43.66
-
CSI 6.76rCSI 74.01%PRS 56.24
-
CSI 6.71rCSI 14.82%PRS 29
-
CSI 6.68rCSI 19.82%PRS 50.56
-
CSI 6.68rCSI 5.18%PRS 39.21
-
CSI 6.62rCSI 8.49%PRS 43.63
-
CSI 6.61rCSI 5.29%PRS 60.21
-
CSI 6.59rCSI 6.09%PRS 59.21
-
CSI 6.43rCSI 5.99%PRS 38.93
-
CSI 6.17rCSI 26.64%PRS 55.96
-
CSI 6.16rCSI 5.41%PRS 43.87
-
CSI 6.09rCSI 16.16%PRS 52.4
-
CSI 6.03rCSI 4.59%PRS 49.54
-
CSI 5.97rCSI 6.24%PRS 39.08
-
CSI 5.95rCSI 13.34%PRS 25.94
-
CSI 5.89rCSI 8.64%PRS 49.7
-
CSI 5.88rCSI 5.56%PRS 40.27
-
CSI 5.65rCSI 3.95%PRS 40.83
-
CSI 5.54rCSI 7.41%PRS 47.02
-
CSI 5.52rCSI 8.45%PRS 55.22
-
CSI 5.48rCSI 5.68%PRS 44.59
-
CSI 5.46rCSI 5.62%PRS 56.25
-
CSI 5.46rCSI 4.58%PRS 44.21
-
CSI 5.35rCSI 10.21%PRS 55.56
-
CSI 5.34rCSI 11.36%PRS 54.18
-
CSI 5.27rCSI 6.29%PRS 25.36
-
CSI 5.21rCSI 4.32%PRS 39.94
-
CSI 5.19rCSI 29.75%PRS 50.14
-
CSI 5.14rCSI 32.12%PRS 32.68
-
CSI 5.08rCSI 19.02%PRS 33.35
-
CSI 5.06rCSI 3.36%PRS 43.2
-
CSI 4.97rCSI 7.09%PRS 41.86
-
CSI 4.95rCSI 5.19%PRS 36.67
-
CSI 4.95rCSI 5.98%PRS 46.04
-
CSI 4.88rCSI 4.48%PRS 45.87
-
CSI 4.86rCSI 12.83%PRS 46.02
-
CSI 4.85rCSI 15.56%PRS 47.41
-
CSI 4.74rCSI 33.48%PRS 65.17
-
CSI 0.1rCSI 2.6%PRS 62.1%
-
CSI 0.2rCSI 1.3%PRS 51.3%
-
CSI 0.2rCSI 3.5%PRS 65.5%
-
CSI 0.3rCSI 4.9%PRS 87.8%
-
CSI 0.3rCSI 3.7%PRS 66.1%
-
CSI 0.3rCSI 1.7%PRS 75.6%
-
CSI 0.3rCSI 3.3%PRS 68.1%
-
CSI 0.4rCSI 1.3%PRS 26.5%
-
CSI 0.5rCSI 3.5%PRS 59.6%
-
CSI 0.5rCSI 4.6%PRS 81.0%
-
CSI 0.5rCSI 10.3%PRS 32.9%
-
CSI 0.5rCSI 3.4%PRS 73.5%
-
CSI 0.5rCSI 2.9%PRS 55.3%
-
CSI 0.6rCSI 0.5%PRS 47.5%
-
CSI 0.6rCSI 6.7%PRS 66.6%
-
CSI 0.6rCSI 12.2%PRS 34.1%
-
CSI 0.6rCSI 4.7%PRS 57.1%
-
CSI 0.6rCSI 2.8%PRS 33.9%
-
CSI 0.7rCSI 1.9%PRS 47.9%
-
CSI 0.7rCSI 2.3%PRS 28.5%
-
CSI 0.7rCSI 3.4%PRS 75.8%
-
CSI 0.8rCSI 4.1%PRS 78.9%
-
CSI 0.8rCSI 2.8%PRS 24.4%
-
CSI 0.8rCSI 3.8%PRS 50.2%
-
CSI 0.9rCSI 1.2%PRS 67.2%
-
CSI 0.9rCSI 1.5%PRS 25.4%
-
CSI 0.9rCSI 3.3%PRS 52.6%
-
CSI 0.9rCSI 2.2%PRS 55.8%
-
CSI 1.0rCSI 4.8%PRS 66.2%
-
CSI 1.1rCSI 1.7%PRS 33.2%
-
CSI 1.1rCSI 6.7%PRS 75.5%
-
CSI 1.1rCSI 3.1%PRS 40.8%
-
CSI 1.1rCSI 3.0%PRS 54.0%
-
CSI 1.1rCSI 1.8%PRS 27.4%
-
CSI 1.1rCSI 2.9%PRS 39.3%
-
CSI 1.1rCSI 2.0%PRS 24.5%
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CSI 1.2rCSI 3.4%PRS 62.6%
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CSI 1.2rCSI 2.2%PRS 30.2%
-
CSI 1.2rCSI 2.2%PRS 59.4%
-
CSI 1.2rCSI 7.9%PRS 70.9%
-
CSI 1.2rCSI 3.2%PRS 62.2%
-
CSI 1.2rCSI 2.9%PRS 51.6%
-
CSI 1.2rCSI 4.4%PRS 57.8%
-
CSI 1.2rCSI 2.7%PRS 48.9%
-
CSI 1.2rCSI 6.7%PRS 62.7%
-
CSI 1.3rCSI 5.6%PRS 37.8%
-
CSI 1.3rCSI 2.0%PRS 45.5%
-
CSI 1.3rCSI 13.0%PRS 65.8%
-
CSI 1.3rCSI 2.9%PRS 53.8%
-
CSI 1.3rCSI 1.6%PRS 58.9%
-
CSI 1.4rCSI 8.2%PRS 26.6%
-
CSI 1.4rCSI 2.1%PRS 36.0%
-
CSI 1.4rCSI 3.9%PRS 54.8%
-
CSI 1.5rCSI 2.7%PRS 54.9%
-
CSI 1.5rCSI 2.0%PRS 26.3%
-
CSI 1.7rCSI 2.3%PRS 59.5%
-
CSI 1.7rCSI 2.6%PRS 39.6%
-
CSI 1.7rCSI 2.1%PRS 57.8%
-
CSI 1.8rCSI 9.0%PRS 63.2%
-
CSI 1.8rCSI 4.6%PRS 48.4%
-
CSI 1.8rCSI 2.7%PRS 40.7%
-
CSI 1.8rCSI 3.7%PRS 61.7%
-
CSI 1.9rCSI 1.7%PRS 29.6%
-
CSI 1.9rCSI 2.4%PRS 41.7%
-
CSI 2.0rCSI 4.5%PRS 38.1%
-
CSI 2.0rCSI 9.3%PRS 63.0%
-
CSI 2.0rCSI 48.6%PRS 25.7%
-
CSI 2.0rCSI 48.2%PRS 24.9%
-
CSI 2.0rCSI 19.9%PRS 66.9%
-
CSI 2.0rCSI 3.1%PRS 43.6%
-
CSI 2.1rCSI 2.2%PRS 37.0%
-
CSI 2.1rCSI 5.5%PRS 35.8%
-
CSI 2.2rCSI 2.4%PRS 54.8%
-
CSI 2.2rCSI 29.0%PRS 73.3%
-
CSI 2.2rCSI 67.1%PRS 64.3%
-
CSI 2.3rCSI 3.2%PRS 36.6%
-
CSI 2.3rCSI 2.6%PRS 62.0%
-
CSI 2.4rCSI 3.0%PRS 52.2%
-
CSI 2.4rCSI 6.0%PRS 37.3%
-
CSI 2.4rCSI 3.3%PRS 36.6%
-
CSI 2.4rCSI 2.8%PRS 49.9%
-
CSI 2.5rCSI 9.6%PRS 26.3%
-
CSI 2.6rCSI 14.8%PRS 42.1%
-
CSI 2.6rCSI 3.1%PRS 30.3%
-
CSI 2.7rCSI 13.3%PRS 49.4%
-
CSI 2.7rCSI 3.3%PRS 24.1%
-
CSI 2.7rCSI 7.7%PRS 54.0%
-
CSI 2.7rCSI 3.7%PRS 33.7%
-
CSI 2.8rCSI 4.4%PRS 33.8%
-
CSI 2.8rCSI 2.1%PRS 42.0%
-
CSI 2.8rCSI 30.7%PRS 60.1%
-
CSI 2.8rCSI 3.6%PRS 44.1%
-
CSI 2.9rCSI 2.1%PRS 51.2%
-
CSI 2.9rCSI 8.3%PRS 41.7%
-
CSI 2.9rCSI 2.3%PRS 60.4%
-
CSI 2.9rCSI 4.7%PRS 48.8%
-
CSI 2.9rCSI 6.5%PRS 45.1%
-
CSI 2.9rCSI 3.5%PRS 37.4%
-
CSI 2.9rCSI 9.4%PRS 36.3%
-
CSI 3.0rCSI 5.1%PRS 65.2%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3141379442
Symbol: UQCC2_HUMAN
Name: Ubiquinol-cytochrome c reductase complex assembly factor 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 19643811
Title: Association of a novel mitochondrial protein M19 with mitochondrial nucleoids.
PubMed ID: 19643811
DOI: 10.1093/jb/mvp118
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22363741
Title: M19 modulates skeletal muscle differentiation and insulin secretion in pancreatic beta-cells through modulation of respiratory chain activity.
PubMed ID: 22363741
PubMed ID: 24385928
Title: Mutations in the UQCC1-interacting protein, UQCC2, cause human complex III deficiency associated with perturbed cytochrome b protein expression.
PubMed ID: 24385928
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 126
- Mass: 14875
- Checksum: 7B840C1AAC74D797
- Sequence:
MAASRYRRFL KLCEEWPVDE TKRGRDLGAY LRQRVAQAFR EGENTQVAEP EACDQMYESL ARLHSNYYKH KYPRPRDTSF SGLSLEEYKL ILSTDTLEEL KEIDKGMWKK LQEKFAPKGP EEDHKA