Details for: ATP6V0D1
Gene ID: 9114
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: ATP6V0D1
Ensembl ID: ENSG00000159720
Description: ATPase H+ transporting V0 subunit d1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 61.31rCSI 56.29%PRS 41.53
-
CSI 43.95rCSI 43.22%PRS 37.55
-
CSI 36.7rCSI 28.28%PRS 33.7
-
CSI 29.28rCSI 30.68%PRS 37.38
-
CSI 25.61rCSI 17.25%PRS 43.82
-
CSI 24.12rCSI 39.73%PRS 40.2
-
CSI 24.1rCSI 42.5%PRS 43.57
-
CSI 21.43rCSI 40.45%PRS 44.14
-
CSI 19.08rCSI 32.69%PRS 44.36
-
CSI 17.71rCSI 34.45%PRS 36.7
-
CSI 15.47rCSI 24.44%PRS 35.91
-
CSI 15.06rCSI 22.73%PRS 36.5
-
CSI 14.57rCSI 22.21%PRS 32.76
-
CSI 12.14rCSI 31.39%PRS 32.37
-
CSI 12.09rCSI 48.1%PRS 51.3
-
CSI 12.07rCSI 26.71%PRS 32.79
-
CSI 11.01rCSI 51.35%PRS 59.99
-
CSI 10.75rCSI 11.52%PRS 33.09
-
CSI 10.41rCSI 13.92%PRS 42.8
-
CSI 10.4rCSI 9%PRS 38.88
-
CSI 10.18rCSI 29.5%PRS 28.47
-
CSI 9.91rCSI 10.1%PRS 47.12
-
CSI 9.57rCSI 57.93%PRS 61.48
-
CSI 9rCSI 20.18%PRS 23.1
-
CSI 8.97rCSI 14.47%PRS 45.63
-
CSI 8.97rCSI 11.5%PRS 39.78
-
CSI 8.26rCSI 6.21%PRS 37.92
-
CSI 7.73rCSI 6.25%PRS 35.7
-
CSI 7.66rCSI 6.92%PRS 32.5
-
CSI 7.36rCSI 6.79%PRS 36.37
-
CSI 7.2rCSI 11%PRS 39.59
-
CSI 7.13rCSI 20.45%PRS 51
-
CSI 7.08rCSI 14.06%PRS 35.39
-
CSI 6.99rCSI 36.71%PRS 51.22
-
CSI 6.71rCSI 10.31%PRS 41.35
-
CSI 6.54rCSI 11.88%PRS 50.71
-
CSI 6.48rCSI 13.39%PRS 43.91
-
CSI 6.04rCSI 25.07%PRS 47.39
-
CSI 6.03rCSI 4.46%PRS 30.32
-
CSI 5.82rCSI 4.05%PRS 42.39
-
CSI 5.7rCSI 14.49%PRS 32.92
-
CSI 5.67rCSI 21.94%PRS 55.49
-
CSI 5.64rCSI 14.3%PRS 27.69
-
CSI 5.61rCSI 13.33%PRS 47.76
-
CSI 5.35rCSI 6.27%PRS 48.68
-
CSI 5.33rCSI 24.61%PRS 58.66
-
CSI 5.25rCSI 12.47%PRS 41.16
-
CSI 5.23rCSI 11.55%PRS 25.92
-
CSI 5.19rCSI 3.45%PRS 39.62
-
CSI 5.18rCSI 11.75%PRS 41.48
-
CSI 5.13rCSI 3.9%PRS 45.05
-
CSI 5.1rCSI 16.54%PRS 39.05
-
CSI 4.9rCSI 15.32%PRS 25.48
-
CSI 4.88rCSI 5.19%PRS 51.1
-
CSI 4.83rCSI 4.25%PRS 26.32
-
CSI 4.78rCSI 6.52%PRS 30.37
-
CSI 4.72rCSI 9.09%PRS 65.16
-
CSI 4.62rCSI 7.43%PRS 24.42
-
CSI 4.57rCSI 3.59%PRS 41
-
CSI 4.55rCSI 3.8%PRS 60.4
-
CSI 4.46rCSI 3.37%PRS 46.29
-
CSI 4.4rCSI 4.56%PRS 40.69
-
CSI 4.33rCSI 9.88%PRS 34.62
-
CSI 4.32rCSI 3.35%PRS 35
-
CSI 4.3rCSI 3.4%PRS 25.08
-
CSI 4.27rCSI 7.67%PRS 29.92
-
CSI 4.14rCSI 10.91%PRS 41.67
-
CSI 4.01rCSI 7.65%PRS 51.62
-
CSI 3.92rCSI 3.14%PRS 56.01
-
CSI 3.88rCSI 6%PRS 33.5
-
CSI 3.88rCSI 21.7%PRS 49.83
-
CSI 3.86rCSI 15.71%PRS 34.72
-
CSI 3.8rCSI 13.68%PRS 21.55
-
CSI 3.76rCSI 4.73%PRS 48.49
-
CSI 3.72rCSI 4.76%PRS 72.45
-
CSI 3.72rCSI 6.02%PRS 34.48
-
CSI 3.67rCSI 5.08%PRS 41.84
-
CSI 3.65rCSI 5.85%PRS 65.71
-
CSI 3.64rCSI 4.1%PRS 50.71
-
CSI 3.61rCSI 4.18%PRS 26.96
-
CSI 3.59rCSI 20.87%PRS 46.78
-
CSI 3.58rCSI 3.52%PRS 49.74
-
CSI 3.56rCSI 3.43%PRS 27.32
-
CSI 3.54rCSI 5.65%PRS 30.29
-
CSI 3.53rCSI 4.4%PRS 46.16
-
CSI 3.51rCSI 7.89%PRS 56.92
-
CSI 3.48rCSI 5.11%PRS 45.18
-
CSI 3.48rCSI 7.77%PRS 40.9
-
CSI 3.47rCSI 5.14%PRS 39.62
-
CSI 3.42rCSI 3.57%PRS 35.9
-
CSI 3.33rCSI 4%PRS 33.84
-
CSI 3.33rCSI 4.55%PRS 39.36
-
CSI 3.31rCSI 12.38%PRS 30.09
-
CSI 3.28rCSI 5.05%PRS 40.19
-
CSI 3.27rCSI 3.15%PRS 36.05
-
CSI 3.24rCSI 2.26%PRS 37.06
-
CSI 3.21rCSI 2.85%PRS 34.81
-
CSI 3.14rCSI 7.19%PRS 34.81
-
CSI 3.12rCSI 7.12%PRS 30.43
-
CSI 3.11rCSI 15.61%PRS 44.93
-
CSI 0.1rCSI 1.4%PRS 58.2%
-
CSI 0.2rCSI 2.4%PRS 60.0%
-
CSI 0.3rCSI 2.5%PRS 66.3%
-
CSI 0.3rCSI 4.4%PRS 64.0%
-
CSI 0.3rCSI 1.2%PRS 57.6%
-
CSI 0.3rCSI 2.2%PRS 55.8%
-
CSI 0.3rCSI 2.0%PRS 67.6%
-
CSI 0.3rCSI 1.8%PRS 70.2%
-
CSI 0.3rCSI 0.5%PRS 51.7%
-
CSI 0.4rCSI 2.6%PRS 63.3%
-
CSI 0.4rCSI 1.8%PRS 52.5%
-
CSI 0.4rCSI 3.8%PRS 77.5%
-
CSI 0.6rCSI 6.1%PRS 72.4%
-
CSI 0.6rCSI 2.5%PRS 33.9%
-
CSI 0.6rCSI 1.6%PRS 50.2%
-
CSI 0.6rCSI 3.3%PRS 23.7%
-
CSI 0.7rCSI 2.2%PRS 43.8%
-
CSI 0.7rCSI 3.9%PRS 24.1%
-
CSI 0.7rCSI 3.1%PRS 55.4%
-
CSI 0.7rCSI 3.2%PRS 25.2%
-
CSI 0.7rCSI 3.2%PRS 51.8%
-
CSI 0.8rCSI 1.4%PRS 21.8%
-
CSI 0.8rCSI 1.7%PRS 57.2%
-
CSI 0.8rCSI 1.8%PRS 45.1%
-
CSI 0.8rCSI 1.4%PRS 22.6%
-
CSI 0.8rCSI 1.1%PRS 55.9%
-
CSI 0.9rCSI 0.8%PRS 59.4%
-
CSI 0.9rCSI 2.9%PRS 46.6%
-
CSI 0.9rCSI 3.0%PRS 69.4%
-
CSI 0.9rCSI 1.1%PRS 23.3%
-
CSI 0.9rCSI 2.4%PRS 44.0%
-
CSI 0.9rCSI 1.7%PRS 56.1%
-
CSI 0.9rCSI 2.6%PRS 59.7%
-
CSI 0.9rCSI 1.9%PRS 58.0%
-
CSI 0.9rCSI 5.7%PRS 72.7%
-
CSI 0.9rCSI 10.0%PRS 52.7%
-
CSI 1.0rCSI 2.0%PRS 42.4%
-
CSI 1.0rCSI 4.6%PRS 56.2%
-
CSI 1.0rCSI 2.9%PRS 38.1%
-
CSI 1.0rCSI 2.1%PRS 52.7%
-
CSI 1.1rCSI 2.3%PRS 55.8%
-
CSI 1.1rCSI 1.9%PRS 27.6%
-
CSI 1.1rCSI 1.6%PRS 28.2%
-
CSI 1.1rCSI 0.8%PRS 47.6%
-
CSI 1.1rCSI 2.9%PRS 41.4%
-
CSI 1.1rCSI 2.5%PRS 49.6%
-
CSI 1.1rCSI 1.4%PRS 53.9%
-
CSI 1.2rCSI 3.3%PRS 53.8%
-
CSI 1.2rCSI 1.4%PRS 39.0%
-
CSI 1.2rCSI 3.5%PRS 50.5%
-
CSI 1.2rCSI 3.9%PRS 23.5%
-
CSI 1.2rCSI 4.4%PRS 49.3%
-
CSI 1.3rCSI 1.7%PRS 46.2%
-
CSI 1.3rCSI 7.2%PRS 70.0%
-
CSI 1.3rCSI 1.9%PRS 36.4%
-
CSI 1.3rCSI 1.7%PRS 47.9%
-
CSI 1.3rCSI 2.1%PRS 27.8%
-
CSI 1.3rCSI 10.4%PRS 54.1%
-
CSI 1.3rCSI 2.1%PRS 51.5%
-
CSI 1.4rCSI 7.7%PRS 46.4%
-
CSI 1.4rCSI 3.3%PRS 38.3%
-
CSI 1.4rCSI 1.7%PRS 54.4%
-
CSI 1.4rCSI 15.4%PRS 56.5%
-
CSI 1.4rCSI 1.8%PRS 31.7%
-
CSI 1.4rCSI 3.3%PRS 55.4%
-
CSI 1.5rCSI 2.1%PRS 32.7%
-
CSI 1.5rCSI 2.1%PRS 50.5%
-
CSI 1.5rCSI 3.1%PRS 50.3%
-
CSI 1.5rCSI 2.9%PRS 59.1%
-
CSI 1.5rCSI 2.4%PRS 27.7%
-
CSI 1.5rCSI 2.2%PRS 45.1%
-
CSI 1.6rCSI 2.4%PRS 35.6%
-
CSI 1.6rCSI 2.5%PRS 44.5%
-
CSI 1.6rCSI 2.9%PRS 27.0%
-
CSI 1.6rCSI 2.3%PRS 37.6%
-
CSI 1.6rCSI 10.7%PRS 71.3%
-
CSI 1.6rCSI 3.9%PRS 52.7%
-
CSI 1.6rCSI 2.9%PRS 51.6%
-
CSI 1.7rCSI 2.2%PRS 63.8%
-
CSI 1.7rCSI 2.3%PRS 33.4%
-
CSI 1.7rCSI 2.1%PRS 37.7%
-
CSI 1.7rCSI 3.2%PRS 70.6%
-
CSI 1.7rCSI 1.5%PRS 43.4%
-
CSI 1.7rCSI 3.0%PRS 28.7%
-
CSI 1.7rCSI 5.0%PRS 56.4%
-
CSI 1.7rCSI 2.6%PRS 38.6%
-
CSI 1.8rCSI 1.5%PRS 40.2%
-
CSI 1.8rCSI 3.2%PRS 30.7%
-
CSI 1.8rCSI 4.7%PRS 58.5%
-
CSI 1.8rCSI 1.8%PRS 30.4%
-
CSI 1.8rCSI 2.1%PRS 30.9%
-
CSI 1.8rCSI 1.5%PRS 36.1%
-
CSI 1.9rCSI 5.5%PRS 53.4%
-
CSI 1.9rCSI 3.0%PRS 43.7%
-
CSI 2.0rCSI 4.8%PRS 33.5%
-
CSI 2.0rCSI 5.2%PRS 48.6%
-
CSI 2.0rCSI 4.8%PRS 32.9%
-
CSI 2.0rCSI 19.5%PRS 63.6%
-
CSI 2.0rCSI 2.7%PRS 38.1%
-
CSI 2.0rCSI 1.5%PRS 53.1%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1067442254
Symbol: VA0D1_HUMAN
Name: V-type proton ATPase subunit d 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8250920
Title: Cloning and tissue distribution of subunits C, D, and E of the human vacuolar H(+)-ATPase.
PubMed ID: 8250920
PubMed ID: 11118322
Title: Structure of the VPATPD gene encoding subunit D of the human vacuolar proton ATPase.
PubMed ID: 11118322
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12384298
Title: Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis.
PubMed ID: 12384298
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21844891
Title: A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo.
PubMed ID: 21844891
DOI: 10.1038/cr.2011.134
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 28296633
Title: The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1alpha prolyl hydroxylation by regulating cellular iron levels.
PubMed ID: 28296633
DOI: 10.7554/elife.22693
PubMed ID: 29644770
Title: TMEM55B contributes to lysosomal homeostasis and amino acid-induced mTORC1 activation.
PubMed ID: 29644770
DOI: 10.1111/gtc.12583
PubMed ID: 30374053
Title: TMEM9 promotes intestinal tumorigenesis through vacuolar-ATPase-activated Wnt/beta-catenin signalling.
PubMed ID: 30374053
PubMed ID: 33065002
Title: Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly.
PubMed ID: 33065002
Sequence Information:
- Length: 351
- Mass: 40329
- Checksum: A720F8A87511203C
- Sequence:
MSFFPELYFN VDNGYLEGLV RGLKAGVLSQ ADYLNLVQCE TLEDLKLHLQ STDYGNFLAN EASPLTVSVI DDRLKEKMVV EFRHMRNHAY EPLASFLDFI TYSYMIDNVI LLITGTLHQR SIAELVPKCH PLGSFEQMEA VNIAQTPAEL YNAILVDTPL AAFFQDCISE QDLDEMNIEI IRNTLYKAYL ESFYKFCTLL GGTTADAMCP ILEFEADRRA FIITINSFGT ELSKEDRAKL FPHCGRLYPE GLAQLARADD YEQVKNVADY YPEYKLLFEG AGSNPGDKTL EDRFFEHEVK LNKLAFLNQF HFGVFYAFVK LKEQECRNIV WIAECIAQRH RAKIDNYIPI F