Details for: SEC11C
Gene ID: 90701
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: SEC11C
Ensembl ID: ENSG00000166562
Description: SEC11 homolog C, signal peptidase complex subunit
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 98.82rCSI 97.19%PRS 62.86
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CSI 92.29rCSI 72.6%PRS 66.97
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CSI 81.44rCSI 83.38%PRS 75.14
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CSI 74.12rCSI 100%PRS 65.62
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CSI 73.54rCSI 77.04%PRS 63.87
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CSI 67.58rCSI 88.57%PRS 85.79
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CSI 66.26rCSI 79.38%PRS 77.21
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CSI 62.71rCSI 67.21%PRS 59.53
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CSI 62.66rCSI 76.28%PRS 67.77
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CSI 43.17rCSI 68.57%PRS 71.32
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CSI 41.31rCSI 91.46%PRS 58.13
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CSI 38.22rCSI 56.04%PRS 71.8
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CSI 37.81rCSI 50.26%PRS 66.72
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CSI 37.51rCSI 51.1%PRS 52.05
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CSI 36.4rCSI 37.7%PRS 65.7
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CSI 35.13rCSI 51.87%PRS 76.28
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CSI 33.16rCSI 29.16%PRS 48.1
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CSI 31.43rCSI 45.3%PRS 71.18
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CSI 30.89rCSI 27.42%PRS 58.32
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CSI 30.27rCSI 36.14%PRS 79.93
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CSI 30.16rCSI 41.21%PRS 62.04
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CSI 27.21rCSI 51.06%PRS 75.66
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CSI 25.11rCSI 36.74%PRS 64.66
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CSI 23.49rCSI 18.21%PRS 61.9
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CSI 23.44rCSI 45.59%PRS 63.11
-
CSI 21.8rCSI 19.15%PRS 65.73
-
CSI 21.75rCSI 86.57%PRS 73.15
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CSI 20.95rCSI 20.17%PRS 60.44
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CSI 20.04rCSI 77.48%PRS 74.98
-
CSI 20.01rCSI 13.97%PRS 62.95
-
CSI 19.44rCSI 63.04%PRS 60.89
-
CSI 18.81rCSI 83.63%PRS 91.37
-
CSI 18.14rCSI 39.94%PRS 64.54
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CSI 17.34rCSI 80.84%PRS 77.49
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CSI 16.82rCSI 15.32%PRS 75.06
-
CSI 15.99rCSI 16.69%PRS 60.53
-
CSI 15.79rCSI 25.31%PRS 81.4
-
CSI 15.66rCSI 12.98%PRS 59.27
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CSI 15.64rCSI 34.43%PRS 73.13
-
CSI 15.63rCSI 14.45%PRS 79.82
-
CSI 15.52rCSI 11.96%PRS 60.64
-
CSI 15.33rCSI 68.97%PRS 89.68
-
CSI 14.98rCSI 35.61%PRS 69.41
-
CSI 14.78rCSI 10.28%PRS 75.52
-
CSI 14.31rCSI 18.22%PRS 66.85
-
CSI 14.29rCSI 11.3%PRS 47.15
-
CSI 14.29rCSI 77.78%PRS 76.33
-
CSI 13.52rCSI 29.52%PRS 74.25
-
CSI 13.48rCSI 10.13%PRS 65.72
-
CSI 13.06rCSI 15.11%PRS 50.31
-
CSI 12.94rCSI 15.19%PRS 62.56
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CSI 12.93rCSI 20.81%PRS 49.89
-
CSI 12.68rCSI 14.7%PRS 68.03
-
CSI 12.55rCSI 20.55%PRS 49.55
-
CSI 12.43rCSI 20.47%PRS 65.66
-
CSI 12.41rCSI 11.96%PRS 50.81
-
CSI 12.28rCSI 11.61%PRS 59.75
-
CSI 12.06rCSI 19.54%PRS 56.87
-
CSI 11.97rCSI 56.12%PRS 78.45
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CSI 11.91rCSI 13.41%PRS 76.65
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CSI 11.77rCSI 12.3%PRS 58.33
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CSI 11.73rCSI 8.15%PRS 71.3
-
CSI 11.7rCSI 50.53%PRS 73
-
CSI 11.64rCSI 62.62%PRS 72.64
-
CSI 11.5rCSI 26.24%PRS 52.11
-
CSI 11.42rCSI 27.09%PRS 64
-
CSI 11.35rCSI 24.16%PRS 71.82
-
CSI 11.24rCSI 15.38%PRS 53.99
-
CSI 11.09rCSI 7.96%PRS 74.73
-
CSI 11.06rCSI 11.03%PRS 53.45
-
CSI 11.04rCSI 14.77%PRS 60.59
-
CSI 10.83rCSI 43.26%PRS 76.57
-
CSI 10.73rCSI 7.15%PRS 80.49
-
CSI 10.64rCSI 8.05%PRS 74.19
-
CSI 10.48rCSI 21.26%PRS 39.81
-
CSI 10.45rCSI 24.53%PRS 65.37
-
CSI 10.2rCSI 15.55%PRS 56.61
-
CSI 10.04rCSI 37.9%PRS 46.84
-
CSI 9.95rCSI 14.58%PRS 56.51
-
CSI 9.94rCSI 12.75%PRS 57.54
-
CSI 9.92rCSI 21.72%PRS 68.47
-
CSI 9.77rCSI 28.02%PRS 80
-
CSI 9.76rCSI 7.3%PRS 75.51
-
CSI 9.75rCSI 12.5%PRS 64.97
-
CSI 9.62rCSI 14.92%PRS 67.97
-
CSI 9.58rCSI 7.68%PRS 80.74
-
CSI 9.43rCSI 48.36%PRS 87.31
-
CSI 9.37rCSI 16.56%PRS 41.18
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CSI 9.32rCSI 9.76%PRS 56.76
-
CSI 9.28rCSI 9.55%PRS 76.82
-
CSI 9.22rCSI 18.51%PRS 49.36
-
CSI 9.14rCSI 6.83%PRS 77.06
-
CSI 9.12rCSI 7.56%PRS 62.31
-
CSI 9.08rCSI 20.36%PRS 42.93
-
CSI 9.04rCSI 51.43%PRS 80.36
-
CSI 8.95rCSI 6.8%PRS 73.29
-
CSI 8.93rCSI 14.24%PRS 53
-
CSI 8.9rCSI 16.18%PRS 75.59
-
CSI 8.86rCSI 15.54%PRS 52.23
-
CSI 8.78rCSI 11.95%PRS 72.16
-
CSI 0.1rCSI 2.1%PRS 96.0%
-
CSI 0.3rCSI 2.5%PRS 77.8%
-
CSI 0.3rCSI 1.5%PRS 69.9%
-
CSI 0.4rCSI 4.2%PRS 78.1%
-
CSI 0.6rCSI 4.7%PRS 86.7%
-
CSI 0.6rCSI 1.9%PRS 43.7%
-
CSI 0.7rCSI 3.9%PRS 87.9%
-
CSI 0.8rCSI 2.9%PRS 43.0%
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CSI 0.9rCSI 1.2%PRS 65.8%
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CSI 0.9rCSI 1.5%PRS 42.1%
-
CSI 1.0rCSI 4.0%PRS 59.8%
-
CSI 1.0rCSI 1.3%PRS 43.4%
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CSI 1.1rCSI 2.1%PRS 70.9%
-
CSI 1.1rCSI 2.8%PRS 40.8%
-
CSI 1.2rCSI 4.2%PRS 79.9%
-
CSI 1.2rCSI 7.1%PRS 75.5%
-
CSI 1.2rCSI 18.8%PRS 78.0%
-
CSI 1.2rCSI 3.7%PRS 78.0%
-
CSI 1.5rCSI 4.8%PRS 86.0%
-
CSI 1.5rCSI 6.6%PRS 87.4%
-
CSI 1.5rCSI 10.5%PRS 75.0%
-
CSI 1.8rCSI 4.3%PRS 61.5%
-
CSI 1.8rCSI 10.6%PRS 69.5%
-
CSI 1.8rCSI 1.6%PRS 71.0%
-
CSI 1.9rCSI 2.9%PRS 73.8%
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CSI 1.9rCSI 11.9%PRS 79.8%
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CSI 2.0rCSI 5.2%PRS 49.8%
-
CSI 2.1rCSI 3.3%PRS 44.2%
-
CSI 2.1rCSI 11.7%PRS 69.5%
-
CSI 2.1rCSI 2.9%PRS 56.5%
-
CSI 2.1rCSI 5.3%PRS 68.4%
-
CSI 2.1rCSI 1.7%PRS 60.8%
-
CSI 2.3rCSI 4.1%PRS 68.6%
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CSI 2.3rCSI 17.5%PRS 76.6%
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CSI 2.4rCSI 4.5%PRS 88.4%
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CSI 2.4rCSI 8.6%PRS 69.4%
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CSI 2.5rCSI 3.8%PRS 69.3%
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CSI 2.6rCSI 17.6%PRS 73.6%
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CSI 2.6rCSI 3.9%PRS 64.4%
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CSI 2.6rCSI 8.8%PRS 64.7%
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CSI 2.6rCSI 7.5%PRS 50.0%
-
CSI 2.7rCSI 5.1%PRS 80.1%
-
CSI 2.7rCSI 3.3%PRS 48.0%
-
CSI 2.8rCSI 4.2%PRS 60.9%
-
CSI 2.8rCSI 5.9%PRS 59.7%
-
CSI 2.9rCSI 4.5%PRS 84.2%
-
CSI 3.0rCSI 4.6%PRS 76.0%
-
CSI 3.1rCSI 28.4%PRS 71.0%
-
CSI 3.1rCSI 71.6%PRS 79.5%
-
CSI 3.1rCSI 19.9%PRS 78.1%
-
CSI 3.1rCSI 3.7%PRS 42.0%
-
CSI 3.1rCSI 53.2%PRS 82.8%
-
CSI 3.2rCSI 14.1%PRS 59.7%
-
CSI 3.2rCSI 47.0%PRS 75.4%
-
CSI 3.2rCSI 2.9%PRS 57.1%
-
CSI 3.3rCSI 5.8%PRS 57.3%
-
CSI 3.3rCSI 16.7%PRS 72.8%
-
CSI 3.4rCSI 10.8%PRS 65.5%
-
CSI 3.4rCSI 6.7%PRS 58.1%
-
CSI 3.4rCSI 7.8%PRS 56.7%
-
CSI 3.5rCSI 6.2%PRS 59.4%
-
CSI 3.5rCSI 4.4%PRS 72.4%
-
CSI 3.7rCSI 5.4%PRS 69.8%
-
CSI 3.8rCSI 19.4%PRS 81.7%
-
CSI 3.8rCSI 11.8%PRS 46.3%
-
CSI 3.9rCSI 5.3%PRS 67.5%
-
CSI 3.9rCSI 7.0%PRS 35.1%
-
CSI 3.9rCSI 4.9%PRS 62.1%
-
CSI 4.0rCSI 20.0%PRS 84.9%
-
CSI 4.0rCSI 7.9%PRS 77.4%
-
CSI 4.0rCSI 8.8%PRS 46.6%
-
CSI 4.1rCSI 5.1%PRS 70.8%
-
CSI 4.1rCSI 8.4%PRS 50.8%
-
CSI 4.1rCSI 7.0%PRS 78.5%
-
CSI 4.1rCSI 7.4%PRS 53.4%
-
CSI 4.1rCSI 3.6%PRS 65.2%
-
CSI 4.1rCSI 7.1%PRS 69.1%
-
CSI 4.1rCSI 15.8%PRS 51.2%
-
CSI 4.2rCSI 7.8%PRS 48.7%
-
CSI 4.2rCSI 4.1%PRS 76.2%
-
CSI 4.2rCSI 10.3%PRS 54.0%
-
CSI 4.2rCSI 5.8%PRS 80.1%
-
CSI 4.3rCSI 10.4%PRS 78.0%
-
CSI 4.4rCSI 4.4%PRS 73.5%
-
CSI 4.5rCSI 3.8%PRS 77.3%
-
CSI 4.6rCSI 12.3%PRS 67.7%
-
CSI 4.8rCSI 5.6%PRS 71.6%
-
CSI 4.8rCSI 7.2%PRS 62.0%
-
CSI 4.9rCSI 6.7%PRS 84.7%
-
CSI 5.0rCSI 9.5%PRS 86.2%
-
CSI 5.0rCSI 7.2%PRS 76.3%
-
CSI 5.0rCSI 14.4%PRS 61.8%
-
CSI 5.1rCSI 13.1%PRS 60.1%
-
CSI 5.2rCSI 15.0%PRS 73.9%
-
CSI 5.2rCSI 10.4%PRS 77.9%
-
CSI 5.2rCSI 9.4%PRS 73.8%
-
CSI 5.3rCSI 12.1%PRS 64.3%
-
CSI 5.4rCSI 5.7%PRS 70.8%
-
CSI 5.4rCSI 7.2%PRS 69.2%
-
CSI 5.5rCSI 6.8%PRS 40.2%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3721393822
Symbol: SC11C_HUMAN
Name: Signal peptidase complex catalytic subunit SEC11C
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 34388369
Title: Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage.
PubMed ID: 34388369
Sequence Information:
- Length: 192
- Mass: 21542
- Checksum: 74FBC5F765791D9F
- Sequence:
MVRAGAVGAH LPASGLDIFG DLKKMNKRQL YYQVLNFAMI VSSALMIWKG LIVLTGSESP IVVVLSGSME PAFHRGDLLF LTNFREDPIR AGEIVVFKVE GRDIPIVHRV IKVHEKDNGD IKFLTKGDNN EVDDRGLYKE GQNWLEKKDV VGRARGFLPY VGMVTIIMND YPKFKYALLA VMGAYVLLKR ES
Genular Protein ID: 808233330
Symbol: K7EJQ7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16177791
Title: DNA sequence and analysis of human chromosome 18.
PubMed ID: 16177791
DOI: 10.1038/nature03983
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
Sequence Information:
- Length: 161
- Mass: 18095
- Checksum: 556754D7484015F8
- Sequence:
MVRAGAVGAH LPASGLDIFG DLKKMNKRQL YYQVLNFAMI VSSALMIWKG LIVLTGSESP IVVVLSGSME PAFHRGDLLF LTNFREDPIR AGEIVVFKVE GRDIPIVHRV IKVHEKDNGD IKFLTKGDNN EVDDRGLYKE GQNWLEKKDV VGRARGMLFW L