Details for: CISD2
Gene ID: 493856
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: CISD2
Ensembl ID: ENSG00000145354
Description: CDGSH iron sulfur domain 2
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 25.88rCSI 27.11%PRS 46.19
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CSI 24.39rCSI 22.02%PRS 40.3
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CSI 20.09rCSI 15.8%PRS 49.89
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CSI 20.07rCSI 39.03%PRS 45.52
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CSI 17.57rCSI 38.9%PRS 40.93
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CSI 17.16rCSI 30.71%PRS 41.97
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CSI 15.73rCSI 15.47%PRS 45.79
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CSI 12.49rCSI 8.68%PRS 51.84
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CSI 10.54rCSI 23.63%PRS 29.3
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CSI 10.13rCSI 15.55%PRS 50.35
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CSI 9.67rCSI 52.2%PRS 58.18
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CSI 8.99rCSI 21.96%PRS 39.81
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CSI 8.32rCSI 11.06%PRS 48.17
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CSI 8.01rCSI 12.89%PRS 34.71
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CSI 7.92rCSI 12.29%PRS 53.57
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CSI 7.68rCSI 12.2%PRS 54
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CSI 7.6rCSI 15.69%PRS 50.19
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CSI 7.33rCSI 5.48%PRS 58.03
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CSI 6.83rCSI 10.41%PRS 40.43
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CSI 6.58rCSI 7.95%PRS 51.15
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CSI 6.34rCSI 14.46%PRS 42.25
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CSI 6.28rCSI 6.58%PRS 40.92
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CSI 6.23rCSI 4.83%PRS 43.99
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CSI 5.89rCSI 4.48%PRS 54.73
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CSI 5.88rCSI 5.67%PRS 34.63
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CSI 5.87rCSI 34.13%PRS 54.5
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CSI 5.75rCSI 37.01%PRS 65.76
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CSI 5.75rCSI 4.27%PRS 56.51
-
CSI 5.73rCSI 6.45%PRS 59.75
-
CSI 5.72rCSI 11.02%PRS 73.57
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CSI 5.48rCSI 19.47%PRS 56.51
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CSI 5.43rCSI 8.3%PRS 48.15
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CSI 5.28rCSI 30.27%PRS 54.17
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CSI 4.9rCSI 11.12%PRS 49.13
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CSI 4.67rCSI 25.12%PRS 58.84
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CSI 4.35rCSI 3.29%PRS 55.64
-
CSI 4.24rCSI 4.08%PRS 67.6
-
CSI 4.14rCSI 5.43%PRS 79.68
-
CSI 4.05rCSI 4.22%PRS 44.25
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CSI 3.98rCSI 5.01%PRS 56.96
-
CSI 3.9rCSI 3.13%PRS 64.96
-
CSI 3.9rCSI 9.66%PRS 41.65
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CSI 3.88rCSI 4.49%PRS 38.17
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CSI 3.84rCSI 3.83%PRS 38.03
-
CSI 3.66rCSI 5.63%PRS 45.84
-
CSI 3.66rCSI 2.55%PRS 56.23
-
CSI 3.63rCSI 9.23%PRS 39.81
-
CSI 3.63rCSI 4.15%PRS 66.3
-
CSI 3.41rCSI 10.07%PRS 47.54
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CSI 3.4rCSI 2.62%PRS 42.3
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CSI 3.34rCSI 9.59%PRS 60.81
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CSI 3.22rCSI 4.91%PRS 44.2
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CSI 3.15rCSI 3.3%PRS 43.13
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CSI 3.1rCSI 7.27%PRS 52.77
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CSI 2.99rCSI 4.08%PRS 37.33
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CSI 2.96rCSI 6.77%PRS 42.97
-
CSI 2.95rCSI 14.81%PRS 54.38
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CSI 2.91rCSI 2.69%PRS 63.71
-
CSI 2.85rCSI 2.74%PRS 44.08
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CSI 2.81rCSI 3.89%PRS 48.58
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CSI 2.77rCSI 4.28%PRS 41.52
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CSI 2.7rCSI 11.21%PRS 53.13
-
CSI 2.7rCSI 4.36%PRS 52.43
-
CSI 2.7rCSI 15.88%PRS 29.99
-
CSI 2.63rCSI 4.93%PRS 33.81
-
CSI 2.63rCSI 2.69%PRS 62.16
-
CSI 2.61rCSI 3.25%PRS 27.18
-
CSI 2.51rCSI 4%PRS 37.02
-
CSI 2.51rCSI 3.19%PRS 48.72
-
CSI 2.5rCSI 3.42%PRS 48.31
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CSI 2.49rCSI 4.04%PRS 42.12
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CSI 2.49rCSI 1.68%PRS 53.58
-
CSI 2.34rCSI 1.86%PRS 65.49
-
CSI 2.31rCSI 4.63%PRS 33.93
-
CSI 2.28rCSI 3.27%PRS 50.91
-
CSI 2.28rCSI 5.02%PRS 47.54
-
CSI 2.27rCSI 3.04%PRS 51.76
-
CSI 2.18rCSI 2.01%PRS 44.49
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CSI 2.15rCSI 3.77%PRS 36.22
-
CSI 2.13rCSI 1.96%PRS 50.75
-
CSI 2.1rCSI 1.47%PRS 45.24
-
CSI 2.09rCSI 3.7%PRS 27.64
-
CSI 2.07rCSI 1.38%PRS 47.38
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CSI 2.04rCSI 1.93%PRS 44.53
-
CSI 1.98rCSI 2.49%PRS 53.15
-
CSI 1.94rCSI 1.72%PRS 42.63
-
CSI 1.94rCSI 1.6%PRS 42.06
-
CSI 1.93rCSI 1.98%PRS 61.06
-
CSI 1.91rCSI 8.31%PRS 59.34
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CSI 1.91rCSI 2.28%PRS 62.84
-
CSI 1.91rCSI 2.55%PRS 45.09
-
CSI 1.9rCSI 1.67%PRS 48.44
-
CSI 1.88rCSI 4.53%PRS 61.29
-
CSI 1.87rCSI 2.67%PRS 46.22
-
CSI 1.86rCSI 3.34%PRS 37.25
-
CSI 1.76rCSI 3.33%PRS 53.64
-
CSI 1.76rCSI 3.5%PRS 43.05
-
CSI 1.72rCSI 3.79%PRS 32.51
-
CSI 1.72rCSI 2.93%PRS 69.52
-
CSI 1.71rCSI 2.12%PRS 39.56
-
CSI 0.1rCSI 1.3%PRS 66.4%
-
CSI 0.2rCSI 0.9%PRS 55.6%
-
CSI 0.2rCSI 1.9%PRS 70.7%
-
CSI 0.2rCSI 4.0%PRS 77.6%
-
CSI 0.2rCSI 2.4%PRS 64.2%
-
CSI 0.2rCSI 2.7%PRS 69.3%
-
CSI 0.3rCSI 1.6%PRS 78.8%
-
CSI 0.3rCSI 2.2%PRS 74.4%
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CSI 0.3rCSI 1.0%PRS 58.0%
-
CSI 0.4rCSI 1.3%PRS 27.5%
-
CSI 0.4rCSI 1.8%PRS 55.2%
-
CSI 0.4rCSI 1.8%PRS 69.2%
-
CSI 0.4rCSI 3.1%PRS 60.1%
-
CSI 0.4rCSI 2.0%PRS 66.6%
-
CSI 0.4rCSI 1.6%PRS 29.6%
-
CSI 0.5rCSI 2.1%PRS 65.9%
-
CSI 0.5rCSI 1.1%PRS 27.8%
-
CSI 0.5rCSI 2.0%PRS 60.1%
-
CSI 0.5rCSI 2.4%PRS 78.7%
-
CSI 0.5rCSI 2.8%PRS 67.3%
-
CSI 0.6rCSI 0.9%PRS 28.6%
-
CSI 0.6rCSI 2.4%PRS 42.3%
-
CSI 0.6rCSI 1.6%PRS 58.1%
-
CSI 0.6rCSI 2.6%PRS 84.8%
-
CSI 0.6rCSI 2.6%PRS 37.4%
-
CSI 0.6rCSI 2.6%PRS 62.8%
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CSI 0.6rCSI 2.2%PRS 62.6%
-
CSI 0.6rCSI 1.0%PRS 23.4%
-
CSI 0.6rCSI 1.8%PRS 46.1%
-
CSI 0.6rCSI 2.0%PRS 29.8%
-
CSI 0.6rCSI 2.9%PRS 83.7%
-
CSI 0.7rCSI 1.2%PRS 27.0%
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CSI 0.7rCSI 0.9%PRS 52.5%
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CSI 0.7rCSI 8.8%PRS 76.8%
-
CSI 0.7rCSI 1.5%PRS 58.6%
-
CSI 0.7rCSI 2.1%PRS 61.3%
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CSI 0.7rCSI 1.2%PRS 30.7%
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CSI 0.8rCSI 22.7%PRS 68.5%
-
CSI 0.8rCSI 2.6%PRS 51.1%
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CSI 0.8rCSI 1.8%PRS 63.2%
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CSI 0.8rCSI 1.1%PRS 65.8%
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CSI 0.9rCSI 2.7%PRS 32.0%
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CSI 0.9rCSI 1.5%PRS 42.0%
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CSI 0.9rCSI 1.3%PRS 35.3%
-
CSI 0.9rCSI 1.4%PRS 52.4%
-
CSI 0.9rCSI 1.4%PRS 60.7%
-
CSI 0.9rCSI 3.7%PRS 52.4%
-
CSI 0.9rCSI 2.5%PRS 66.2%
-
CSI 1.0rCSI 1.6%PRS 64.3%
-
CSI 1.0rCSI 1.7%PRS 52.8%
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CSI 1.0rCSI 2.8%PRS 35.5%
-
CSI 1.0rCSI 1.6%PRS 49.0%
-
CSI 1.0rCSI 4.0%PRS 65.2%
-
CSI 1.0rCSI 1.8%PRS 70.2%
-
CSI 1.0rCSI 2.5%PRS 34.6%
-
CSI 1.0rCSI 1.5%PRS 48.4%
-
CSI 1.0rCSI 1.6%PRS 59.8%
-
CSI 1.0rCSI 1.2%PRS 47.3%
-
CSI 1.0rCSI 2.5%PRS 53.7%
-
CSI 1.1rCSI 1.4%PRS 64.4%
-
CSI 1.1rCSI 5.5%PRS 79.0%
-
CSI 1.1rCSI 1.4%PRS 46.2%
-
CSI 1.1rCSI 2.1%PRS 66.8%
-
CSI 1.1rCSI 1.3%PRS 34.1%
-
CSI 1.1rCSI 2.5%PRS 53.5%
-
CSI 1.1rCSI 1.6%PRS 46.4%
-
CSI 1.2rCSI 1.9%PRS 34.7%
-
CSI 1.2rCSI 3.9%PRS 53.2%
-
CSI 1.2rCSI 2.1%PRS 59.2%
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CSI 1.2rCSI 4.8%PRS 58.8%
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CSI 1.2rCSI 2.1%PRS 34.7%
-
CSI 1.2rCSI 1.8%PRS 57.1%
-
CSI 1.3rCSI 1.6%PRS 56.5%
-
CSI 1.3rCSI 2.7%PRS 64.7%
-
CSI 1.3rCSI 2.5%PRS 61.3%
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CSI 1.3rCSI 1.5%PRS 41.7%
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CSI 1.3rCSI 4.6%PRS 79.4%
-
CSI 1.3rCSI 1.1%PRS 44.1%
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CSI 1.3rCSI 2.5%PRS 77.5%
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CSI 1.3rCSI 1.4%PRS 41.5%
-
CSI 1.3rCSI 1.0%PRS 46.8%
-
CSI 1.3rCSI 2.5%PRS 63.4%
-
CSI 1.3rCSI 3.2%PRS 55.8%
-
CSI 1.4rCSI 1.9%PRS 43.1%
-
CSI 1.4rCSI 1.4%PRS 58.7%
-
CSI 1.4rCSI 2.1%PRS 53.6%
-
CSI 1.4rCSI 2.0%PRS 53.6%
-
CSI 1.4rCSI 1.2%PRS 48.5%
-
CSI 1.5rCSI 2.2%PRS 45.5%
-
CSI 1.5rCSI 1.3%PRS 33.2%
-
CSI 1.5rCSI 3.0%PRS 26.9%
-
CSI 1.5rCSI 1.5%PRS 49.3%
-
CSI 1.5rCSI 1.9%PRS 29.5%
-
CSI 1.5rCSI 2.2%PRS 54.5%
-
CSI 1.5rCSI 3.9%PRS 39.9%
-
CSI 1.5rCSI 1.8%PRS 28.6%
-
CSI 1.6rCSI 2.0%PRS 41.7%
-
CSI 1.6rCSI 1.4%PRS 52.7%
-
CSI 1.6rCSI 2.3%PRS 60.9%
-
CSI 1.6rCSI 1.3%PRS 31.9%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3557205092
Symbol: CISD2_HUMAN
Name: CDGSH iron-sulfur domain-containing protein 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 17846994
Title: A homozygous mutation in a novel zinc-finger protein, ERIS, is responsible for Wolfram syndrome 2.
PubMed ID: 17846994
DOI: 10.1086/520961
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17376863
Title: MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity.
PubMed ID: 17376863
PubMed ID: 20010695
Title: Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1.
PubMed ID: 20010695
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 19580816
Title: Crystal structure of Miner1: The redox-active 2Fe-2S protein causative in Wolfram Syndrome 2.
PubMed ID: 19580816
Sequence Information:
- Length: 135
- Mass: 15278
- Checksum: 44AD1817D6C536D6
- Sequence:
MVLESVARIV KVQLPAYLKR LPVPESITGF ARLTVSEWLR LLPFLGVLAL LGYLAVRPFL PKKKQQKDSL INLKIQKENP KVVNEINIED LCLTKAAYCR CWRSKTFPAC DGSHNKHNEL TGDNVGPLIL KKKEV